Microbiología

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Determinación de los cambios que genera la presencia de los Iones Mg2+, Ca2+, y Na+en la proliferación de salmonelófagos líticos
(Universidad Santiago de Cali, 2024) Guazá Balanta, María José; Aranaga Arias, Carlos Andrés; Falco Restrepo, Aura Dayana
One of the most common foodborne diseases worldwide is salmonellosis, which is caused by the bacterial genus Salmonella spp. The resistance to antibiotics that this bacteria has conferred begins the search for alternatives for its treatment, phage therapy being one of these. The adhesion of bacteriophages to the cell surface is the first and one of the main stages in viral infection. There are ions such as Mg+2, Ca+2 and Na+ that work as cofactors for the adhesion of bacteriophages to their hosts, resulting in an increase in the viral population. That is why in this work, based on the determination of the viral titer of a bacteriophage infective for Salmonella (4x109 PFU/mL), the changes in its proliferation in the presence of Mg+2, Ca+2 and Na+and ions were determined. The Mg+2 ion was the one in which changes were found that can potentiate the obtaining of the bacteriophage from a complex sample such as a solid environmental matrix