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Asociación entre la falla en la transferencia de inmunidad pasiva y la aparición de hipoglucemia neonatal en potros
(Universidad Santiago de Cali, 2026-08-06) Rincon Valencia, Samuel; Martinez Lozano, Alexander(Director)
Failure of passive transfer of immunity (FPT) constitutes one of the main causes of neonatal morbidity and mortality in foals, while neonatal hypoglycemia represents a common metabolic alteration in this species. This systematic review, developed according to the PRISMA 2020 guidelines, aimed to analyze the available scientific evidence on the association between FPT and the occurrence of neonatal hypoglycemia in foals. A structured search was conducted in PubMed, ScienceDirect, Scopus, Redalyc, and Google Scholar, identifying 44 initial records, of which 21 studies met the eligibility criteria and were included in the qualitative synthesis. The reviewed studies describe two main pathophysiological pathways: a direct one of primary nutritional hypoglycemia due to colostrum deprivation, and an indirect one mediated by sepsis and systemic inflammatory response syndrome, which induces a hypermetabolic state and hepatic dysfunction, exacerbating the energy deficit. The reviewed evidence supports a synergistic interaction between the immunological and metabolic components of the equine neonate, highlighting the importance of early recognition of FPT through Brix refractometry and constant glucose monitoring.
Eficacia, seguridad y perspectivas terapéuticas del cannabis medicinal en el tratamiento del dolor crónico asociado al cáncer: Revisión sistemática
(Universidad Santiago de Cali, 2026-06-24) Cabrera Agreda, Miguel Angel; Melissa Castañeda, Carol(Directora)
Chronic cancer-related pain presents a significant therapeutic challenge due to its complexity and the limitations of traditional treatments, particularly opioids, which can negatively impact quality of life. In this context, medicinal cannabis has emerged as a potential therapeutic option, generating interest within the scientific community. The objective of this study was to analyze the available evidence on the efficacy, safety, and therapeutic prospects of medicinal cannabis in the treatment of chronic cancer-associated pain through a systematic review of the scientific literature. A search was conducted in databases such as PubMed, Scopulus, ScienceDirect, and Web of Science, following the PRISMA methodology. Studies published between 2020 and 2025 that evaluated the use of cannabinoids in cancer patients with chronic pain were included. The results demonstrate documented evidence of the analgesic effect, with an increased percentage of cancer patients achieving chronic pain relief. Furthermore, a favorable safety profile was observed, characterized by the absence of adverse events and good tolerability. Regarding pharmaceutical forms, the oral route was the most frequently used, while the inhaled route showed a faster onset of action. Furthermore, high patient acceptability and a possible opioid-sparing effect were identified. It was concluded that medicinal cannabis is a therapeutic option with potential for treating cancer pain; however, more robust clinical research is needed to reach definitive conclusions about its safety and effectiveness.
Presencia y propagación del gen mcr-1 en bacterias Gramnegativas desde el enfoque One Health: una revisión sistemática
(Universidad Santiago de Cali, 2026-06-26) Avila Zambrano, Lesly Tatiana; Aranaga Arias, Carlos Andrés(Director); Martínez Garay, Carlos Andrés(Director)
Antimicrobial resistance is a growing threat to global public health, especially due to the emergence of resistance mechanisms to last-line antibiotics such as colistin. The plasmid-mediated mcr-1 gene has been identified as a key determinant in the spread of resistance in Gram-negative bacteria, with clinical, veterinary and environmental implications . The objective of this study was to analyze the available evidence on the presence and dissemination of the mcr-1 gene in Latin America, through a systematic review of the scientific literature. A search was conducted in the PubMed, Scopus, SciELO and LILACS databases, including studies published between 2015 and 2025 that reported the detection of the gene in Gram-negative bacteria. Seven studies were selected for qualitative analysis. The results showed a heterogeneous distribution of the gene in the region, with a predominance in Escherichia coli and frequent association with IncI2 and IncX4 plasmids. Its presence was identified in human and animal samples, while studies in environmental matrices were limited. These findings highlight the importance of mobile genetic elements in the spread of colistin resistance and show the need to strengthen surveillance under a One Health approach. However, the limited number of studies and methodological heterogeneity restrict the generalizability of the results. In conclusion, it is necessary to expand research in the region, especially in the environmental component, as well as to standardize detection methods to improve the understanding of the dynamics of mcr-1 gene dissemination.
Impacto del estrés oxidativo en la salud animal, actualidad, consecuencias y tratamiento en medicina veterinaria. Revisión sistemática
(Universidad Santiago de Cali, 2026-09-07) Vega Ramirez,Santiago; Guarin Patarroyo, Camilo(Director); Cabrera Matajira, Carlos(Director)
Oxidative stress (OS) constitutes an imbalance between the production of reactive oxygen species and the capacity of endogenous antioxidant systems to neutralize them, resulting in damage to lipids, proteins, and DNA. In veterinary medicine, this phenomenon has been implicated in multiple diseases of domestic animals, although its recognition and clinical management remain limited. This monograph aimed to analyze the impact of OS on animal health, addressing recent advances in its diagnosis, clinical consequences, and therapeutic strategies. A qualitative literature review was conducted following PRISMA guidelines, through searches in Google Scholar, ScienceDirect, SciELO, PubMed, and Scopus, using keywords such as "oxidative stress", "antioxidants", and "ischemia reperfusion injury". Publications from the last five years in English and Spanish were prioritized, finally selecting articles for analysis. The findings indicated that OS participates in infectious conditions (parvovirosis, paratuberculosis), ischemia-reperfusion (equine colic), metabolic diseases (feline chronic kidney disease), and environmental stress (heat, pollution). Antioxidant strategies such as vitamins E and C, selenium, polyphenols, and resveratrol were identified, with varying levels of evidence depending on the species and clinical condition.
Therapeutic protocols for large and small animals were proposed. It is concluded that OS is an active pathophysiological mechanism that can precipitate death in scenarios such as equine colic and canine parvovirosis, and that its monitoring and antioxidant treatment may mprove prognosis, although further studies are required to standardize doses and biomarkers in each species.
Eficacia de la deslorelina como anticonceptivo en zarigüeyas macho (Didelphis marsupialis)
(Universidad Santiago de Cali, 2026-07-16) Osorio León, Lina Maria; Bermeo Sierra, Marta Liliana(Directora); Orjuela Acosta, Delio(Director)
The overabundance of opossums (Didelphis marsupialis) in urban environments represents an ecological and public health challenge, highlighting the need for effective non-lethal population control strategies. This study aimed to evaluate the efficacy of a 4.7 mg subcutaneous deslorelin implant as a contraceptive in adult males of this species. A longitudinal experimental study was conducted at a wildlife rescue center in Cali, Colombia, including 16 individuals assigned to a control group (n = 8) and a treatment group (n = 8). Reproductive function was assessed by measuring sperm concentration and testicular volume before treatment (T0) and 15 days post-implantation (T1). The treated group showed a marked reduction in sperm concentration, with azoospermia observed in 62.5% of individuals (5/8). One individual exhibited a severe decrease, one a moderate reduction, and one showed an increase consistent with a transient stimulatory (“flare-up”) effect. In contrast, the control group maintained stable sperm concentrations (34–83 million/mL), with no relevant changes between T0 and T1. A general reduction in testicular volume was also observed in treated individuals, whereas no significant variations were detected in the control group. These findings indicate that deslorelin induces rapid suppression of spermatogenesis in male Didelphis marsupialis, representing a promising non-lethal alternative for reproductive control under ex situ management conditions. However, variability in individual response highlights the need for further studies to assess the duration and consistency of the effect.