Repositorio Institucional
Universidad Santiago de Cali
Communities
Select a community to browse its collections.
Documentos Autoarchivo USC
Recent Submissions
Marcadores hematologicos y bioquimicos en la Erliquiosis canina segun la etapa de la enfermedad. Revisión sistemática.
(Universidad Santiago de Cali, 2026-05-25) Arcila Ramirez, Mayra Alejandra; Cardona Tobar, Karen Melissa(Directora)
Canine ehrlichiosis is a tick-borne infectious disease that affects dogs in tropical and subtropical regions and can cause hematological and biochemical alterations that reflect the systemic impact of the infection. The objective of this study was to analyze the most frequent hematological and biochemical markers in dogs with canine ehrlichiosis, considering the different clinical stages of the disease, through a systematic review of the scientific literature. To this end, research and selection of scientific articles was conducted in biomedical databases that reported hematological, biochemical, or biomarker alterations associated with Ehrlichia canis infection. The included studies were analyzed and organized into three main categories: hematological changes, biochemical alterations associated with organ involvement, and emerging biomarkers with diagnostic or prognostic potential. The results showed that the most frequent hematological alterations were thrombocytopenia, anemia, and leukopenia, which can present with varying intensity depending on the clinical phase of the disease and the presence of coinfections. Regarding biochemical changes, hepatic, renal, and protein metabolism alterations were identified, including increases in liver enzymes, changes in serum proteins, and alterations in renal parameters, suggesting multisystem organ involvement. Furthermore, recent studies have described emerging biomarkers, such as cardiac troponin, C-reactive protein, inflammatory cytokines, and urinary biomarkers, which could contribute to a more accurate assessment of disease severity and associated organ damage. Taken together, these findings demonstrate that integrating hematological, biochemical, and emerging biomarker parameters, along with molecular and serological diagnostic methods, can improve early detection, clinical monitoring, and pathophysiological understanding of Canine ehrlichiosis.
Análisis del crecimiento radial y producción de conidios de hongos filamentosos expuestos a diferentes longitudes de onda de luz.
(Universidad Santiago de Cali, 2026-07-23) Garcia Vanegas, Maria Camila; González Vargas, Iván Andrés(Director); Corredor Sáenz, Viviana Catalina(Directora)
Fungal photobiology studies how fungi perceive and respond to light as an environmental signal. This study evaluated the effect of four wavelengths—blue (462 nm), green (518 nm), red (631 nm), and white (455 nm)—on 14 filamentous fungal isolates from the genera Aspergillus spp., Trichoderma spp., and Penicillium spp., with the aim of determining how each wavelength influences radial growth, conidia production, and catalase enzyme activity under a 12-hour light/dark photoperiod. Growth was measured on PDA medium, while conidia production and catalase enzyme activity were evaluated on PDB medium. Twelve of the 14 isolates showed significant differences in radial growth (wavelength effect F(4,206) = 10.74; p < 0.0001; isolate effect F(13,206) = 71.68; p < 0.0001). White light was the wavelength with the greatest effect on growth (p = 0.0098 vs. control), followed by blue light. The greatest increase was recorded in isolate TH24 (Trichoderma spp.) under red light, which went from 2.60 cm in darkness to 6.94 cm (an increase of approximately 167%), while TH25 responded significantly to all four wavelengths. In conidia production, no treatment reached statistical significance compared to the control (p > 0.05). However, green light (p=0.0639) and white light (p=0.0920) were close to the threshold, with the greatest increase observed under white light in isolate 39-39 (Aspergillus spp.). In contrast, red and green lights showed more variable effects and, in some cases, neutral or inhibitory effects on the analyzed parameters. Catalase activity showed significant differences according to wavelength (F(4,206) = 85.64; p<0.0001): blue and white light increased enzyme activity compared to the control (p<0.0001 in both cases). The highest value in the entire experiment was recorded in isolate 9I10 (Aspergillus spp.) under white light, with an increase of approximately 9.5 times compared to its control in darkness, suggesting an increase in the response mechanisms to oxidative stress. These differences among the fungal isolates suggest taxonomically distinct antioxidant responses. It is concluded that the spectral quality of light significantly influences radial growth, conidia production, and catalase activity in the studied filamentous fungi, highlighting the potential of blue and white wavelengths as tools for modulating processes of biotechnological interest and understanding the mechanisms associated with fungal photobiology.
Propiedades antineoplásicas de la familia Annonaceae: Una revisión sistemática
(Universidad Santiago de Cali, 2026-06-23) Borja Pinto, Emilie Valentina; Illicachi Romero, Luis Alberto(Director)
Cancer is recognized as one of the leading causes of death worldwide, highlighting the need to develop new therapeutic alternatives based on naturally occurring bioactive compounds. In this context, the Annonaceae family is identified as a significant source of metabolites with potential anticancer activity. The objective of this study is to analyze and synthesize the available scientific evidence regarding the anticancer potential of various species of the genus Annona and other related species. A literature review was conducted focusing on preclinical studies and phytochemical reports, in which cytotoxic activity, mechanisms of action, and strategies to improve the bioavailability of bioactive compounds were evaluated. The findings show that extracts and isolated metabolites, particularly acetogenins, exhibited significant cytotoxic activity against multiple tumor cell lines. The mechanisms of action include caspase-mediated apoptosis induction, regulation of proteins associated with cell survival, generation of oxidative stress, and disruption of mitochondrial function. Furthermore, it is observed that strategies such as nanoencapsulation improve the stability of these compounds. It is concluded that Annonaceae species represent a promising source for the development of new anticancer agents; however, clinical evidence is limited, indicating the need for further human studies to validate their safety and efficacy.
Prevalencia del linfoma en caninos adultos durante el 2024 en dos clinicas veterinarias de la ciudad Santiago de Cali, Colombia
(Universidad Santiago de Cali, 2026-07-22) Angulo Racines, Milton Andres; Perea Bravo, Juliana Teresa; Cardona Tobar, Karen Melissa(Directora)
This study addresses canine lymphoma, a critical and prevalent neoplasm in veterinary oncology, a pathology of great relevance to veterinarians interested in tumor treatment. This review determined the prevalence of lymphoma in adult dogs treated during 2024 at two veterinary clinics in Santiago de Cali, Colombia, and described its distribution by age, sex, breed, and diagnostic method. An observational, descriptive, and retrospective study was conducted by reviewing 124 medical records. Six confirmed diagnoses of lymphoma were identified, resulting in a low prevalence of 4.83%. The highest proportion of cases occurred in geriatric and male dogs; however, no statistically significant association was found with age or sex. The Cocker Spaniel breed was the most represented, aligning the review with international molecular genetic research that recognizes this breed as having one of the highest genetic risks for developing lymphoma. Histopathology was the most frequently used diagnostic method due to its ability to provide a detailed structural evaluation of the tissue, allowing for a more precise classification of the type of neoplasm, especially in pathologies such as lymphoma. It is concluded that the observed prevalence was low and no significant associations were established in the evaluated population, highlighting the need for future research with a larger sample size due to the small number of lymphoma cases diagnosed, which limited the statistical power of the tests performed, preventing the identification of a statistically significant association between variables such as age range and the presence of lymphoma.
Prevalencia de bacterias asociadas a ETAS en carne de res comercializada para consumo humano en galerías de Santiago de cali
(Universidad santiago de cali, 2026-06-23) Ruiz Ibarra, Nina Astrid; Apraez Viveros, Tania Stephany; Duque, Juan Diego(Director); Guarin, Camilo Ernesto(Director)
Beef is one of the main sources of animal protein in the Colombian population’s diet. However, during production, slaughter, transportation, and commercialization, it may become contaminated with pathogenic bacteria that compromise food safety and represent a risk to public health. The aim of this study was to determine the prevalence of Escherichia coli and Salmonella spp. in beef marketed in public marketplaces in Santiago de Cali. Six fresh beef samples were randomly collected from different retail points. The samples were transported under controlled conditions and processed through microbiological analyses following the Colombian Technical Standards NTC 4458 and NTC 4574. The results showed a prevalence of Salmonella spp. of 83.3% (5/6 samples) and E. coli of 33.3% (2/6 samples), values that exceed the microbiological criteria established for food intended for human consumption. These findings suggest deficiencies in hygienic and sanitary conditions during meat handling and commercialization, which may increase the risk of foodborne diseases among consumers and highlight the need to strengthen sanitary surveillance and microbiological control measures in beef retail establishments in Santiago de Cali.