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Relación entre los niveles de Ácido Úrico en la sangre y los tipos de dietas en caninos: un estudio nutricional
(Universidad Santiago de Cali, 2026-08-27) Collazos Paz, Jose Manuel; Escobar Lozada, Isabella; Rodríguez Neira, Cristian Fernando(Director)
This study analyzes the relationship between uric acid levels in the blood of canines in Santiago de Cali and three types of diets: concentrated feed, BARF (biologically appropriate raw food) diets, and mixed diets. The sample consisted of 35 healthy canines, evaluated through biochemical analyses and characterization surveys. The results showed that canines on a BARF diet presented the highest average uric acid levels (1.34 mg/dL), followed by the mixed diet (0.87 mg/dL) and the concentrated feed (0.72 mg/dL). Frequent consumption of offal was identified as the main dietary factor associated with increased uric acid levels. Additionally, a critical impact of hemolysis was quantified, which artificially raises uric acid levels by up to 97%, underscoring the importance of pre-analytical quality in veterinary diagnosis. It is concluded that there is a direct correlation between the type of diet and the purine profile, which requires adjustments in preventive nutritional recommendations.
Síntesis y caracterización de un nuevo material orgánico basado en fenotiazina para aplicaciones fotovoltaicas
(Universidad Santiago de Cali, 2026-06-23) Pizarro Perafan, Jessica Tatiana; Rios Ballesteros, Liseth; Illicachi Romero, Luis Alberto(Director)
In the present research work, the synthesis of a compound as a hole transporter (HTMs) was carried out, which allows the passage of positive charges and blocks the transport of negative charges for the production of electrical energy in perovskite solar cells. To this end, the synthesis was carried out by a Buchwald–Hartwig coupling reaction, followed by a bromination reaction, obtaining the compound 3,7-dibromo-10-(3,4,5-trimethoxyphenyl)-10H-phenothiazine (compound 4) with a yield of 45.9%. The synthesis of this compound was verified by infrared spectroscopy, where C-N, C-C and C-Br bonds were evidenced. In addition, it was characterized by mass spectrometry, whose spectrum showed the mass-charge ratio of the molecular ion and the characteristic fragmentations of the proposed molecule. Similarly, to complement the characterization, compound 4 was analyzed by ¹H NMR spectroscopy, whose spectra evidenced the presence of the hydrogens corresponding to the proposed structure. Subsequently, it was characterized by ultraviolet-visible spectroscopy and fluorescence, obtaining molar absorptivity and bandgap energy. These results, based on theory, suggest that the compound shows signs of being a good void transporter material. Finally, TD-DFT analyses were carried out in Gaussian to estimate the electron transitions of compound 4, the results showed three excitation states with energies of 3.4397, 3.6405 and 3.7147 eV, corresponding to wavelengths of 360.45, 340.57 and 333.76 nm, respectively. The most intense transition presented an oscillator force of 0.2008, while the first transition showed a significant contribution with lower intensity (f = 0.0275). In addition to obtaining the data regarding the energies of HOMO and LUMO of compound 4 corresponding to –5.38 eV and –0.81 eV respectively, where, the HOMO level facilitates the efficient extraction of holes, while the LUMO acts as a barrier that blocks the transport of electrons, potentially reducing charge recombination.
PLASMA RICO EN PLAQUETAS (PRP): IMPACTO EN LA REPARACIÓN DE HERIDAS EN PERROS Y GATOS.
(Universidad Santiago de Cali, 2026-09-01) Reyes Vélez, Adriana Alejandra; Ospina Bolaños, Carlos Adrián(Director)
This research addressed the persistent and complex problem of skin wound healing in small animals (dogs and cats), starting from the premise that traditional approaches are insufficient for extensive lesions or comorbidities. The objective was to conduct a comprehensive analysis of the advances and scientific evidence regarding the use of platelet-rich plasma (PRP) and its derivatives from a regenerative medicine perspective. To this end, the accumulated scientific evidence was reviewed, with an emphasis on recent research, on the biological basis of platelet concentrates, their molecular mechanisms of action, and the critical variables in their preparation. Efficacy studies in canine and feline species were analyzed, including acute, subacute, and complex wounds (diabetic, cytostatic extravasation), as well as in immunocompromised patients. The antimicrobial properties of these concentrates were also evaluated. The results confirmed that PRP and its derivatives, such as PRF, accelerate macroscopic wound closure, improve the quality of regenerated tissue, and promote neovascularization. Furthermore, their regulatory capacity was demonstrated in diabetic patients through the modulation of gene expression, as well as their usefulness in felines, where they help compensate for the naturally slow healing process. In addition, antimicrobial activity against common pathogens was observed. Taken together, these findings support the scientific rigor and clinical versatility of this therapy. However, they also highlight the need for strict standardization of preparation and reporting protocols in order to consolidate the use of PRP and its derivatives as a potential standard of care in modern veterinary medicine.
Diagnóstico clínico de la Diabetes Mellitus tipo 1 en caninos: revisión sistemática de los avances y perspectivas en Medicina Interna.
(Universidad Santiago de Cali, 2026-09-03) Tenorio Angulo, Diego Fernando; Cardona Tobar, Karen Melissa(Directora)
Type 1 Diabetes Mellitus (DM1) in canines is one of the most frequent endocrinopathies in veterinary medicine and represents an important diagnostic challenge due to the clinical variability and limitations of the available laboratory methods. This study aimed to evaluate recent scientific evidence on the clinical diagnostic methods used in the detection of DM1 in dogs, as well as to analyze the advances and emerging perspectives in veterinary internal medicine. A systematic descriptive and analytical review was developed, based on the PRISMA methodology, by searching for scientific articles published between 2020 and 2025 in the PubMed and Scopus databases. Original studies related to diagnostic tests, biomarkers, clinical findings and laboratory tools applied to canines with a confirmed diagnosis of diabetes mellitus were included. The results showed that the diagnosis continues to be based on anamnesis, cardinal clinical signs and conventional laboratory tests such as glycemia, uroanalysis and fructosamine; however, recent research has identified inflammatory, immunological and proteomic biomarkers with potential diagnostic and prognostic utility. Likewise, limitations were observed in the sensitivity and specificity of some traditional methods, as well as a lack of diagnostic standardization in veterinary clinical practice. It was concluded that advances in immunological biomarkers and molecular techniques could contribute to improving diagnostic accuracy and favor an earlier, more comprehensive and personalized clinical approach to DM1 in canines.
NANOPARTÍCULAS DE QUITOSANO COMO ESTRATEGIA INNOVADORA EN LA LIBERACIÓN DIRIGIDA DE FÁRMACOS PARA EL TRATAMIENTO DEL CÁNCER: REVISIÓN DE LITERATURA
(Universidad Santiago de Cali, 2026-09-02) Benavides Lopez, Kevin R.; Ciro Monsalve, Yhors Alexander(Director)
Cancer represents a major global public health challenge, driving the need for more efficient, selective, and safer therapeutic strategies. In this context, chitosan-based nanoparticles have emerged as promising platforms for controlled drug delivery in oncology. This systematic review, based on literature published between 2020 and 2026 and conducted under PRISMA guidelines, analyzes recent advances in the design, synthesis, and application of these nanometric systems in the treatment of various cancers, including breast, lung, colorectal, prostate, and gastric cancer. Chitosan, as a polycationic biopolymer, exhibits favorable physicochemical properties such as biocompatibility, biodegradability, mucoadhesion, and high functionalization capacity, enabling efficient encapsulation of chemotherapeutic agents and targeted delivery to tumor cells. The analyzed studies demonstrate that chitosan nanoparticles enhance drug bioavailability, enable sustained and controlled release, and improve permeability across biological barriers, thereby reducing systemic toxicity and increasing therapeutic efficacy. Furthermore, modulation of parameters such as molecular weight, surface charge, and synthesis techniques allows tailoring of nanoparticle properties for specific oncological applications. Overall, these nanoplatforms represent an innovative strategy with high potential for the development of more effective, safe, and targeted cancer therapies.