Repositorio Institucional
Universidad Santiago de Cali
Communities
Select a community to browse its collections.
Documentos Autoarchivo USC
Recent Submissions
Registro Digital Blockchain como una herramienta de control preventiva en el ingreso de materia prima ilegal: una revisión sistemática
(Universidad Santiago de Cali, 2026-06-11) Trochez Rengifo,Tamara; Restrepo Zapata, Jorge Humberto (Director)
The commercialization of illegal medicines is a sanitary and regulatory problem that
compromises patient safety, therapeutic effectiveness, and trust in health systems.
Counterfeiting, adulteration, unauthorized distribution, and marketing of products
without sanitary authorization reveal weaknesses in pharmaceutical supply chain
traceability, especially in contexts with fragmented logistics, unverified electronic
commerce, and limited inspection capacity. This systematic review analyzed the
usefulness of blockchain technology as a preventive control tool to reduce the entry of
illegal medicines into the pharmaceutical supply chain. Studies published between 2020
and 2025 were reviewed in ScienceDirect, PubMed, Scopus, and Springer using terms
related to blockchain, traceability, pharmaceutical supply chain, counterfeiting, and
illegal medicines. Selection was guided by defined inclusion and exclusion criteria, with
screening of titles, abstracts, and full texts. The selected articles show that blockchain
provides immutable records, event authentication, smart contracts, controlled
interoperability, and greater visibility among manufacturers, distributors, regulatory
authorities, and dispensers. The reviewed models, including Medledger, PharmaChain,
IPFS-based solutions, IoT sensors, and homomorphic encryption, show concrete
applications in serialization, batch traceability, cold chain control, and inconsistency
detection. Implementation requires overcoming technical, regulatory, economic, and
training barriers, but represents a relevant alternative for strengthening sanitary control
and the transparency of pharmaceutical processes.
Revisión sistemática sobre los contaminantes emergentes en el agua: retos para su detección y monitoreo desde la perspectiva del análisis ambiental
(Universidad Santiago de Cali, 2026-06-19) Villa Sánchez,Bryan Alexander; Mosquera González, Sergio David(Director)
Emerging contaminants in water constitute one of the most complex challenges for analytical chemistry and contemporary environmental monitoring. This term encompasses compounds such as pharmaceuticals, personal care products, endocrine disruptors, PFAS, pesticides, flame retardants, microplastics, and other persistent, mobile, or toxic organic contaminants which, although not always “new,” have gained relevance due to their increasing detection, widespread distribution, and potential ecological and health effects. Their analysis represents a challenge because of their enormous structural diversity, their presence at trace or ultra-trace concentrations, the complexity of aquatic matrices, and the formation of transformation products. In this context, environmental chemistry has evolved from traditional targeted approaches toward broader strategies based on chromatography coupled with high-resolution mass spectrometry, suspect screening (targeted analysis) and non-targeted analysis, electrochemical sensors, biosensors, and bioassays. This monograph examines the problem from the perspective of environmental chemistry, focusing on the main challenges for detection and monitoring, as well as the most relevant methodological responses. It concludes that effective monitoring of emerging contaminants requires integrated approaches that combine advanced chemical analysis, emerging and complementary techniques and technologies, mixture assessment, prioritization tools, and dynamic regulatory frameworks, in order to move from the simple identification of compounds toward more preventive, representative, and risk-oriented environmental surveillance.
Evaluación de la Actividad Antimicrobiana de la Amoxicilina Cargada en Nanocristales de Celulosa (CNCs) Frente a Bacterias Asociadas a Infecciones Cutáneas
(Universidad Santiago de Cali, 2026-07-30) Ángel Cañón, Harrison Smith; Ceballos Coral, Manuel Alejandro; Castañeda Aedo, Carol Melissa (Director); Chamorro Rengifo, Andrés Felipe (Director)
Bacterial skin infections represent a major public health challenge due to antimicrobial resistance and the limitations of conventional antibiotic delivery systems. In this context, nanocellulose has emerged as a promising alternative for the development of controlled drug delivery systems for antibiotics facing significant challenges, such as amoxicillin (AMX). Therefore, the aim of this study was to obtain cellulose nanocrystals (CNCs) through sulfuric acid hydrolysis followed by TEMPO-mediated functionalization (TOCNCs) to evaluate their ability to adsorb and release AMX against pathogenic bacteria. Both materials were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Transmission Electron Microscopy (TEM), and Dynamic Light Scattering (DLS), confirming the incorporation of sulfate and carboxyl groups as well as the association of the drug with the nanocrystals. Adsorption was evaluated as a function of contact time, medium pH, and solute concentration. The results showed that TOCNCs exhibited the highest drug retention after 6 hours (42.56 ± 1.5%), with adsorption being favored under acidic conditions (pH 3). Antibacterial inhibition assays demonstrated that AMX adsorbed onto the nanocrystal surface retained its antibacterial activity against Staphylococcus aureus and Escherichia coli, highlighting the potential application of these nanomaterials as controlled drug delivery matrices.
Docking molecular aplicado a péptidos antimicrobianos: una revisión sistemática de sus interacciones con dianas bacterianas.
(Universidad Santiago de Cali, 2026-06-24) Rivera Molina,Angie Julieth; Oñate Garzón, José Fernando(Director); Ciro Monsalve, Yhors Alexander(Director)
The emergence of antimicrobial resistance has become a serious global public health problem, leading to the
search for new therapeutic alternatives such as antimicrobial peptides. The objective of this study was to analyze
the available evidence on the use of molecular docking for predicting and evaluating the interaction of antimicrobial
peptides with bacterial targets. A systematic review was conducted following the PRISMA 2020 guidelines; the
review included studies published between 2020 and 2026 in international biomedical databases.
The results showed that molecular docking was primarily used to estimate binding energies, identify key residues,
and guide the rational design of peptides targeting essential enzymes and bacterial regulatory proteins;
furthermore, a growing trend was observed toward integrating docking with molecular dynamics and experimental
validation. It was concluded that docking is a useful tool for peptide selection and mechanistic analysis, but its
predictive value depends on methodological standardization and its correlation with biological experimental
evidence.
El Efecto de Cannabis sativa en el cuidado de la piel: una revisión sistemática
(Universidad Santiago de Cali, 2026-05-08) Pérez Galindo, Dahiana Fernanda
Topical products based on phytochemical compounds from Cannabis Sativa (hemp or marijuana) represent a promising alternative for the skincare industry. This plant has been the subject of historical study and is valued in traditional, ancestral, homeopathic, and allopathic medicine due to its complex chemical composition. Among its components, delta-9-tetrahydrocannabinol (THC) stands out, with psychoactive properties and concentrations ranging from 0.5% to 5% in flowers and leaves, as well as other cannabinoids with high industrial potential: cannabidiol (CBD), cannabidolic acid, cannabicidol, and cannabigerol (CBG). Phytochemical analysis has identified more than 60 cannabinoids and 200 additional compounds, opening up a wide range of opportunities for innovation in various production sectors. In this context, this review article aims to identify the scientific evidence on the use of phytocannabinoids in the development of specific products, such as emulsions and creams for dermal application. The results of the systematic review indicate that scientific production on research into the use of Cannabis Sativa has grown steadily, reaching its peak in 2021. The sustainable geographic scope, predominantly from Colombia, Spain, and the United States, also incorporates perspectives from more than 20 countries, supported by bibliographic references from original articles, specialized journals, legal regulations, and grey literature. The research period covers the years 2013 to 2023. Finally, the research was characterized as a multidisciplinary and international study, with strong support from databases such as ScienceDirect and PubMed, among others.