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MANIFESTACIONES HEMATOLÓGICAS ASOCIADAS A LA INFECCIÓN POR DIROFILARIA SPP EN CANINOS. REVISIÓN SISTEMÁTICA.
(Universidad Santiago de Cali, 2026-05-25) Quinchia Velez, Juan Esteban; Vargas Camargo, Oscar Julián(Director)
Canine dirofilariasis is a widespread parasitic disease in tropical and subtropical regions. Early diagnosis is key but limited because of the absence of specific clinical signs and the inappropriate use of diagnostic tests in veterinary practice. In this context, this systematic review aimed to identify the hematological alterations associated with Dirofilaria spp. infection in dogs, as well as to evaluate its relationship with the parasite's pathophysiology and its utility as a diagnostic support tool. The results showed that the main hematological manifestations included anemia, eosinophilia, neutrophilia, and thrombocytopenia, in addition, some changes in biochemical parameters related to renal and hepatic disease. These alterations were more frequent in advanced stages of the heartworm disease, while in early stages they were mild or nonspecific. Also, moderate variability was observed among studies and case reports. It was concluded that hematological alterations are not diagnostic on their own, but they can be useful complementary tools in the monitoring and prognosis of the patient suffering from the disease.
Herramientas bioinformáticas in silico para identificar compuestos neuroprotectores en Alzheimer y Parkinson: una Revisión Sistemática
(Universidad Santiago de Cali, 2026-06-10) Ramirez Sanchez, James; Oñate Garzón, José Fernando(Director); Ciro Monsalve, Yhors(Director)
Parkinson's and Alzheimer's diseases represent a growing public health challenge due to their high prevalence, irreversible progression, and the limited efficacy of current treatments. For this reason, the identification of neuroprotective compounds using in silico tools emerges as a promising strategy to optimize the discovery of new pharmacological treatments. This systematic review aims to analyze the potential of these bioinformatics tools in the development of strategies for identifying molecules with neuroprotective activity for both diseases. The methodology was developed following the PRISMA guidelines, through the search, selection, and critical analysis of scientific articles, including studies of molecular docking, molecular dynamics, and experimental validation, evaluating affinity energy and conformational stability. The results showed that for Alzheimer's disease, the main therapeutic targets were acetylcholinesterase (AChE), β-secretase (BACE1), and glycogen synthase kinase-3β (GSK-3β), with molecules such as curcumin, quercetin, and berberine standing out due to their favorable energies and interactions. In Parkinson's disease, the most studied targets were monoamine oxidase B (MAO-B) and alpha synuclein, where compounds such as resveratrol, luteolin, and baicalein showed neuroprotective potential. Based on these findings, in silico tools allowed for the identification of promising compounds and multi-target molecules; however, limited experimental validation and a lack of methodological standardization are factors that affect the reliability of the results.
Impacto clínico de las dietas BARF VS dietas comerciales en la microbiota intestinal canina: Revisión Sistemática
(Universidad Santiago de Cali, 2026-07-15) Gomez Gil, Juliana; Rodríguez Neira, Cristian Fernando(Director)
The canine gut microbiota plays a fundamental role in digestive, metabolic, and immune processes, with diet being one of the main factors capable of altering its composition and function. In recent years, the increasing use of BARF (Biologically Appropriate Raw Food) diets has sparked scientific controversy compared to commercial concentrated diets, due to the potential benefits and risks associated with each dietary approach. The objective of this systematic review was to analyze clinical impact in the gut microbiota of healthy adult dogs fed a BARF diet compared to those fed commercial kibble. The research was conducted as a systematic review based on the PRISMA guidelines, using scientific databases such as Scopus, PubMed, ScienceDirect, Web of Science, and SciELO. Original studies published between 2010 and 2025 related to gut microbiota, canine nutrition, and BARF diets were included. After applying inclusion and exclusion criteria, finallly 44 scientific articles were selected for comparative analysis. The results showed that BARF diets promoted a higher abundance of proteolytic bacteria such as Clostridium and Fusobacterium, as well as greater intestinal bacterial diversity. In contrast, commercial diets favored saccharolytic bacteria such as Lactobacillus and Bifidobacterium, which are associated with the production of short-chain fatty acids beneficial to intestinal health. Furthermore, potential risks related to zoonotic microorganisms present in raw diets were identified. It was concluded that both types of diets cause significant changes in the canine gut microbiota, presenting specific benefits and limitations; therefore, their implementation must consider nutritional, microbiological, and health criteria supported by scientific evidence.
Prevalencia de bacterias de interés clínico en superficies de la clínica veterinaria de un zoológico en Colombia, 2026
(Universidad Santiago de Cali, 2026-06-26) Puerta Cardenas, Yohan Sebastian; Quiroz Mosquera, Nathalia; Duque Zapata, Juan Diego(Director); Peña Standlin, Juliana(Directora)
Veterinary clinics in zoos are highly complex microbiological environments where surfaces can act as reservoirs for bacteria with nosocomial and zoonotic potential. The objective of this study was to determine the prevalence of clinically significant bacteria on surfaces in a zoo veterinary clinic in Colombia during the first half of 2026. A descriptive cross-sectional study was conducted, involving the sampling of 14 surfaces distributed across five clinical areas using sterile swabs and culture on selective media (EMB, MSA, CT, and VRBD). An overall prevalence of 35.7% was observed (5 out of 14 positive surfaces). Klebsiella spp. was the most common genus (29%), followed by Staphylococcus spp. and Escherichia coli (14% each) and Pseudomonas spp. (7%). The reception area (75%) and the procedure room (50%) showed the highest levels of contamination. It is concluded that conditions exist that favor the presence of clinically significant bacteria in the evaluated environment, highlighting the need to strengthen biosafety protocols under the One Health approach.
Filmes eco-amigables de almidón reforzado con nanopartículas de Cu aplicados en la inhibición del crecimiento bacteriano.
(Universidad Santiago de Cali, 2026-06-12) Cuervo Estupiñan, Valeria; Mina Posu,Santiago; Chamorro Rengifo, Andrés Felipe(Director); Palencia Luna, Sixta(Directora)
Antimicrobial resistance represents a global crisis of great impact that threatens public health. In response to this issue, nanotechnology has emerged as an innovative and sustainable alternative, with metallic nanoparticles standing out due to their antimicrobial and wound-healing properties. The present study evaluated the green synthesis of copper metallic nanoparticles (CuNps) using lemon peel extract, followed by their incorporation into starch-based films. The formation of CuNps was confirmed by UV-Vis and DLS, obtaining a band at 229 nm and an average size of 197 nm. FTIR analysis revealed the presence of functional groups in both the CuNps and the polymeric material. The films exhibited adequate structural integrity and hydrophilic behavior, evaluated through swelling, solubility, and contact angle tests. In antimicrobial assays, inhibition zones ranging from 1.35 to 2.05 cm were recorded against both antibiotic-resistant and susceptible bacteria. The films exhibited physical and antimicrobial properties that support their use as wound dressings.