Repositorio Institucional
Universidad Santiago de Cali
Communities
Select a community to browse its collections.
Documentos Autoarchivo USC
Recent Submissions
Estrategias analíticas no dirigidas basadas en HRMS para el perfilado químico de drogas ilícitas y excipientes asociados: Revisión sistemática
(Universidad Santiago De Cali, 2026-05-26) Karol Dayana, Bolaños Dejoy
La complejidad y dinamismo del mercado de sustancias ilegales ha hecho insuficientes los enfoques
analíticos puramente dirigidos, especialmente cuando se busca caracterizar de forma integral tanto la droga
principal como sus excipientes y adulterantes, relevantes para la inteligencia forense y la salud pública. El objetivo
de esta revisión sistemática fue identificar, describir y sintetizar estrategias analíticas no dirigidas basadas en
espectrometría de masas de alta resolución (HRMS) aplicadas al perfilado químico de drogas ilícitas y excipientes
asociados. Se realizó una búsqueda sistemática en Scopus, Web of Science, PubMed y ScienceDirect,
complementada con Google Scholar y revisión de referencias, siguiendo las recomendaciones PRISMA 2020. Se
consideraron estudios publicados entre 2010 y 2025 que emplearan HRMS con componente no dirigido o suspect
screening en muestras incautadas, matrices biológicas o ambientales relacionadas con el uso y tráfico de drogas.
Tras el proceso de cribado y elegibilidad, se incluyó un conjunto final de estudios que describieron flujos de trabajo
basados principalmente en LC–HRMS (UHPLC–QTOF/Orbitrap), MALDI–HRMS y configuraciones híbridas
dirigido/no dirigido. Los resultados mostraron que estas estrategias ampliaron de forma significativa la cobertura
de compuestos, permitieron el reanálisis retrospectivo de datos y favorecieron la caracterización simultánea de
drogas, metabolitos, excipientes y adulterantes, con aplicaciones en toxicología clínica y post mortem, drug
checking, perfilado de incautaciones y vigilancia en aguas residuales. No obstante, se identificaron desafíos
relacionados con la complejidad de los datos, la necesidad de infraestructura especializada y la falta de
estandarización en criterios de identificación y validación. En conclusión, las estrategias HRMS no dirigidas se
consolidan como herramientas centrales para la caracterización química integral de drogas ilícitas y excipientes,
pero requieren avances en guías de validación, bases de datos compartidas y armonización de reportes para
consolidar su uso rutinario en laboratorios forenses.
Importancia clínica en el diagnóstico de mastocitoma cutáneo canino
(Universidad Santiago de Cali, 2024-11-30) Calderón Vallejo, Evelin Tatiana; Ocampo Torres, Jessica
Mastocytomas are neoplasias generated by the abnormal proliferation of mast cells, classified as the most common hematopoietic neoplasia in dogs. There are breeds that are predisposed to this pathology and it is usually associated with geriatric animals. There are no studies that accurately demonstrate incidence according to sex.
This work reviews the literature on the diagnosis of cutaneous mastocytoma in canines, its casuistry, clinical signs, treatment and diagnostic methods, in which we find the Patnai method to classify the histological stage and the kiupel method that allows us to know the degree at which it can remain (high or low).
Nutrición y su influencia en el desarrollo de patologías: comparación de la dieta (barf) vs alimento comercial. Revisión sistemática
(Universidad Santiago de Cali, 2024-11-30) Hidalgo Dager, Katerine; Montenegro Riascos, Natalia; Cardona Tobar, Karen Melissa (Directora)
The growing importance of pets in homes has driven the development of research focused on animal welfare, particularly in the field of nutrition. This study addresses the comparison between the BARF (Biologically Appropriate Raw Food) diet and processed commercial foods for dogs and cats, exploring their effects on the health of these animals. Through a systematic review under the PRISMA methodology, key articles on the impact of both diets were analyzed, in order to know and differentiate which is ideal for pets, in order to provide them with a complete and balanced diet. The results indicate that the BARF diet can enrich the microbiota with beneficial bacteria, although an increase in pathogens and potentially harmful microorganisms is observed. On the other hand, commercial foods, despite losing nutritional value due to their thermal processing, present a safer profile with respect to bacterial contamination. Although both diets have advantages and disadvantages, further long-term research is needed to determine their specific effects on the health and well-being of pets, as well as the cost-effectiveness of each option. This study concludes that caution is needed when selecting diets and research should be encouraged on the nutritional benefits and risks of both options.
Frecuencia y distribución de la casuística canina en dos clínicas veterinarias de cali, durante el año 2023
(Universidad Santiago de Cali, 2024-11-30) Giraldo Londoño, Alfredo; Muñoz Orozco, Yener Aldibey; Patarroyo, Camilo Guarín (Director)
In the daily practice of the small animal clinic it is necessary to have information on the casuistry of the presentation of diseases in small animals, this can set a trend and provide information for decision making. The objective of this study is to describe the frequency and distribution of canine casuistry in two clinics in Cali during 2023. To this end, an observational, descriptive, longitudinal retrospective study was carried out, with the review of all the systematized medical records in the program Okvet of canine patients consulted from January 1 to December 31, 2023, in two veterinary clinics in the city of Cali. The analysis was performed univariate with descriptive statistics according to the distribution of data for the study variables and bivariate with which the association of the dependent variable with the independent variables was explored. Digestive system conditions were the most common, with 296 patients (28.2%), the main cause of consultation was gastroenteritis in 249 patients (23.75% of the patient). Dermatological problems represented the second most common cause of consultation, 15.4% (161 patients attended). Otitis affected 69 canines, representing 6.6%. Finally, musculoskeletal traumas accounted for 7% with 73 patients attended. The results of this study offer an insight into the main conditions affecting canines in Cali clinics, highlighting the importance of prevention, early diagnosis, and appropriate treatment to improve the health and well-being of pets. These findings are essential to improve veterinary clinical practice, allowing for more personalized and effective care. Veterinarians will then be able to offer treatments that are not only based on the disease itself, but also on the individual characteristics of the patient, optimizing health outcomes for each animal.
Estudio retrospectivo de la casuística de pacientes caninos con signos gastrointestinales en una clínica veterinaria de la ciudad de Cali, Colombia
(Universidad Santiago de Cali, 2024-12-07) Mosquera Montoya, Henry Andres; Guarín Patarroyo, Camilo Ernesto (Director)
Canine gastroenteritis is known as the inflammatory process of the structure of the stomach and/ or intestines, it is one of the most frequent diseases in veterinary clinics due to vomiting, diarrhea or anorexia. The methodology of this work was to collect data based on medical records recorded at a veterinary center in the city of Cali in dogs with gastrointestinal signs, and The study was conducted during 2023 by performing univariate and bivariate analyses to obtain the prevalence, determining the dependence between signs of vomiting, diarrhea or both with independent factors. Of the variables found with higher prevalence in vomiting: si (82.2%), diarrhea: si (61.4%), vomiting and diarrhea: no (56.4%), race: french poodle (9.1%), sex: male (52.7%), age: mature adult (27.1%), etiology: parvovirus (19.2%), type of gastroenteritis: parasitic (30.6%) and stratum: 3 (65.1%). The relationship between variables and clinical signs should be studied further, because in several studies there was no mutual agreement on the possible cause of the high relation with geographical distribution.