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Eficacia de la deslorelina como anticonceptivo en zarigüeyas macho (Didelphis marsupialis)
(Universidad Santiago de Cali, 2026-07-16) Osorio León, Lina Maria; Bermeo Sierra, Marta Liliana(Directora); Orjuela Acosta, Delio(Director)
The overabundance of opossums (Didelphis marsupialis) in urban environments represents an ecological and public health challenge, highlighting the need for effective non-lethal population control strategies. This study aimed to evaluate the efficacy of a 4.7 mg subcutaneous deslorelin implant as a contraceptive in adult males of this species. A longitudinal experimental study was conducted at a wildlife rescue center in Cali, Colombia, including 16 individuals assigned to a control group (n = 8) and a treatment group (n = 8). Reproductive function was assessed by measuring sperm concentration and testicular volume before treatment (T0) and 15 days post-implantation (T1). The treated group showed a marked reduction in sperm concentration, with azoospermia observed in 62.5% of individuals (5/8). One individual exhibited a severe decrease, one a moderate reduction, and one showed an increase consistent with a transient stimulatory (“flare-up”) effect. In contrast, the control group maintained stable sperm concentrations (34–83 million/mL), with no relevant changes between T0 and T1. A general reduction in testicular volume was also observed in treated individuals, whereas no significant variations were detected in the control group. These findings indicate that deslorelin induces rapid suppression of spermatogenesis in male Didelphis marsupialis, representing a promising non-lethal alternative for reproductive control under ex situ management conditions. However, variability in individual response highlights the need for further studies to assess the duration and consistency of the effect.
Manejo médico-quirúrgico de fracturas en aves silvestres: revisión sistemática de la literatura y análisis de sus implicaciones en la conservación (2014–2024)
(Universidad Santiago de Cali, 2026-08-26) Medina Galeano, Angie Katherine; Pelegrín Ramírez, Jonathan(Director); Palomino, Lina Marcela(Directora)
Fractures are a leading cause of admission to wildlife rehabilitation centers and directly affect the survival of birds in their natural habitat. This monograph, based on a PRISMA 2020 systematic review of 57 articles published between 2014 and 2024, characterizes the medical-surgical management of fractures in wild birds and examines their implications for conservation efforts. A total of 71 injuries were identified. The most common sites were the tibiotarsus 27%, coracoid 11%, and ulna 11%, which together account for 49% of all cases. This indicates that nearly half of the traumas occur in the pelvic limb and the wing, regions essential for locomotion and flight. Raptors accounted for 87.6% of the reported cases, reflecting a bias toward species of high ecological value. Surgical management predominated over conservative treatment, using external fixators, intramedullary pins, and bone plates. Release rates were higher for long bone fractures and lower for articular or femoral injuries. The study concludes that treatment should be individualized, prioritizing functional recovery for release and applying ethical criteria when the prognosis is unfavorable. From a One Health perspective, the importance of biosecurity and responsible antimicrobial use in rehabilitation centers is highlighted.
Análisis comparativo del uso de corticosteroides betametasona vs prednisolona en otitis externa, media e interna canina. Revisión sistemática
(Universidad Santiago de Cali, 2026-08-31) Perdomo Galeano, Sofia Valentina; Correa Toro, Nelson William(Director)
This systematic review addressed the complex problem of canine otitis, a prevalent inflammatory condition affecting the ear canal and surrounding structures, and one of the most frequent reasons for veterinary visits. The disease, resulting from multiple etiological factors, progresses to severe histological changes such as stenosis and fibrosis, complicating medical therapy. The objective of this review was to compare the effectiveness and safety of betamethasone and prednisolone in the treatment of otitis externa, media, and interna in dogs, considering their distinct pharmacodynamic and pharmacokinetic profiles. The methodology was based on a comparative analysis of the pharmacology of both glucocorticoids, a review of the clinical efficacy reported in studies for different locations of otitis, and an evaluation of their safety profiles, including suppression of the hypothalamic pituitary-adrenal axis and systemic effects. The results indicated that betamethasone, with its high anti-inflammatory potency and prolonged duration of action, was more effective in the rapid control of acute and severe otitis externa, especially in long-acting formulations that improved treatment adherence. However, it was associated with a higher risk of prolonged HPA axis suppression and elevated liver enzymes. On the other hand, prednisolone, with its intermediate potency and shorter duration of action, was established as the gold standard for the systemic treatment of otitis media and interna, as well as for chronic proliferative otitis externa, offering a better safety profile for medium- and long-term treatments. It was concluded that the choice between betamethasone and prednisolone should be precise, recommending topical betamethasone for acute otitis externa due to its effectiveness and ease of administration, and systemic prednisolone for otitis media, interna, and chronic stenotic conditions, due to its balance between systemic anti-inflammatory effectiveness and metabolic safety.
Relación entre los niveles de Ácido Úrico en la sangre y los tipos de dietas en caninos: un estudio nutricional
(Universidad Santiago de Cali, 2026-08-27) Collazos Paz, Jose Manuel; Escobar Lozada, Isabella; Rodríguez Neira, Cristian Fernando(Director)
This study analyzes the relationship between uric acid levels in the blood of canines in Santiago de Cali and three types of diets: concentrated feed, BARF (biologically appropriate raw food) diets, and mixed diets. The sample consisted of 35 healthy canines, evaluated through biochemical analyses and characterization surveys. The results showed that canines on a BARF diet presented the highest average uric acid levels (1.34 mg/dL), followed by the mixed diet (0.87 mg/dL) and the concentrated feed (0.72 mg/dL). Frequent consumption of offal was identified as the main dietary factor associated with increased uric acid levels. Additionally, a critical impact of hemolysis was quantified, which artificially raises uric acid levels by up to 97%, underscoring the importance of pre-analytical quality in veterinary diagnosis. It is concluded that there is a direct correlation between the type of diet and the purine profile, which requires adjustments in preventive nutritional recommendations.
Síntesis y caracterización de un nuevo material orgánico basado en fenotiazina para aplicaciones fotovoltaicas
(Universidad Santiago de Cali, 2026-06-23) Pizarro Perafan, Jessica Tatiana; Rios Ballesteros, Liseth; Illicachi Romero, Luis Alberto(Director)
In the present research work, the synthesis of a compound as a hole transporter (HTMs) was carried out, which allows the passage of positive charges and blocks the transport of negative charges for the production of electrical energy in perovskite solar cells. To this end, the synthesis was carried out by a Buchwald–Hartwig coupling reaction, followed by a bromination reaction, obtaining the compound 3,7-dibromo-10-(3,4,5-trimethoxyphenyl)-10H-phenothiazine (compound 4) with a yield of 45.9%. The synthesis of this compound was verified by infrared spectroscopy, where C-N, C-C and C-Br bonds were evidenced. In addition, it was characterized by mass spectrometry, whose spectrum showed the mass-charge ratio of the molecular ion and the characteristic fragmentations of the proposed molecule. Similarly, to complement the characterization, compound 4 was analyzed by ¹H NMR spectroscopy, whose spectra evidenced the presence of the hydrogens corresponding to the proposed structure. Subsequently, it was characterized by ultraviolet-visible spectroscopy and fluorescence, obtaining molar absorptivity and bandgap energy. These results, based on theory, suggest that the compound shows signs of being a good void transporter material. Finally, TD-DFT analyses were carried out in Gaussian to estimate the electron transitions of compound 4, the results showed three excitation states with energies of 3.4397, 3.6405 and 3.7147 eV, corresponding to wavelengths of 360.45, 340.57 and 333.76 nm, respectively. The most intense transition presented an oscillator force of 0.2008, while the first transition showed a significant contribution with lower intensity (f = 0.0275). In addition to obtaining the data regarding the energies of HOMO and LUMO of compound 4 corresponding to –5.38 eV and –0.81 eV respectively, where, the HOMO level facilitates the efficient extraction of holes, while the LUMO acts as a barrier that blocks the transport of electrons, potentially reducing charge recombination.