Medicina - Palmira
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Browsing Medicina - Palmira by Subject "Autoimmune"
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Item Complicaciones en un paciente con esclerosis sistémica cutánea limitada (síndrome CREST): reporte de caso(Universidad Santiago de Cali, 2024) Riascos Ceballos, Segundo Alex; Cedeño, Diana Vanessa; Londoño, Mario Andrés (Director)Systemic sclerosis is a chronic, heterogeneous disease, most prevalent in middle-aged women, characterized by generalized skin and organ fibrosis, small vessel vasculopathy, and autoantibody production, with subtypes like CREST Syndrome and diffuse cutaneous scleroderma. This case report describes a 76-year-old female patient with a history of scleroderma, Raynaud's syndrome, and pulmonary hypertension, among other comorbidities. The patient was admitted to the emergency department due to fatigue, shortness of breath, and necrosis in three toes of the left foot, a manifestation considered a complication of her underlying CREST Syndrome. Despite intensive management, including immunosuppressive therapy, imaging studies, and balloon angioplasty, no clinical improvement in the necrotic lesions was achieved, ultimately requiring the amputation of the affected phalanges.Item Esclerodermia cutánea localizada (morfea) en un infante: reporte de caso(Universidad Santiago de Cali, 2023) Palacio Herrera, John Edwin; Riascos Ceballos, Gloris; Rodríguez Moncaleano, Nathalya; Molano Agudelo, Pedro (Director)Localized Scleroderma, a rare disease with an incidence of less than 3 new cases per 100,000 people annually, is the most common form in children, primarily affecting females, with an idiopathic etiology characterized by extracellular matrix alterations and collagen overproduction. This research presents the case of an 8-year-old boy with a one-year history of hyperpigmented, linear skin lesions on the left mandibular ramus and a depressed oval lesion on the left lumbar region. After receiving multiple unsuccessful treatments due to initial diagnostic uncertainty, a skin biopsy confirmed Localized Scleroderma Morphea type. The case concludes by emphasizing the need for up-to-date and accurate diagnostic knowledge regarding skin lesions and the importance of prompt differential diagnosis to initiate early and effective pharmacological treatment.