Medicina - Palmira
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Item Manifestaciones Clinicas En Una Portadora De Variante En Setd2: Reporte De Caso Luscan – Lumish(2026-04-29) Folleco Melo, Vanessa Delfary; Larrahondo Murillo, Breyner; Carolina Barahona Rebolledo (Director)Luscan–Lumish syndrome (LLS) is a rare neurodevelopmental disorder associated with variants in the SETD2 gene, characterized by a broad phenotypic spectrum including overgrowth, macrocephaly, and cognitive alterations of variable severity, which is why this clinical case report describes in detail the clinical phenotype, evolution, and genetic characterization of a patient with a pathogenic variant in the SETD2 gene, with an attenuated phenotype. Through a detailed clinical evaluation, neuroimaging, neuropsychological evaluation, and whole-exome sequencing, the diagnosis was defined in a patient who presented predominantly musculoskeletal involvement, while her daughter presented multisystemic involvement, predominantly neurological and developmental in nature, and musculoskeletal disorders, being a clear example of variable intrafamilial expressivity and reduced penetrance. It is concluded that Luscan–Lumish syndrome (LLS) can present with attenuated phenotypes that complicate its clinical recognition, therefore it is important to consider this diagnosis in the case of patients with gigantism and neurodevelopmental disorders, highlighting the importance of molecular genetics tools in the diagnosis of rare diseases and the need for a multidisciplinary approach for their management and follow-up.Item Desafíos En La Fibrinólisis Sistémica En Infarto Agudo De Miocardio Y Accidente Cerebrovascular, Estudio Descriptivo En Un Centro De Tercer Nivel De Palmira, Colombia(2026-04-28) Bermúdez Londoño, Juan Sebastián; García Acevedo, Valentina; Briones Gálvez, Danyary Alejandra; Deving Arias Ramos (Director)Systemic fibrinolysis remains a relevant reperfusion strategy in ST-elevation myocardial infarction (STEMI) and the fundamental treatment in ischemic stroke, which is why this observational, descriptive, cross-sectional study analyzed the medical records of these patients between March 2020 and March 2025 at a tertiary center in Palmira, Colombia. Upon reviewing 5,847 medical records, 1,322 acute stroke and acute coronary syndrome (ACS) events were identified; in ischemic stroke, 46.3% received fibrinolysis with a median door-to-needle time of 78 minutes, in-hospital mortality of 14.3%, intracerebral bleeding in 8.2%, extracranial bleeding in 10.2%, and a median NIHSS that improved from 10 at admission to 3 at discharge, while in STEMI, 60.6% received fibrinolysis with a median door-to-needle time of 23 minutes, in-hospital mortality of 17.5%, and bleeding in 6.3%. It is concluded that systemic fibrinolysis remained a current strategy in patients with STEMI and ischemic stroke treated at a regional referral center; however, care delays, mortality, and hemorrhagic complications highlight opportunities for improvement in the diagnostic pathway, therapeutic timeliness, and interhospital continuity of care.Item Determinantes de la pérdida en el seguimiento y perfil de discapacidad funcional en tuberculosis pulmonar, palmira, Colombia, 2021–2025 Investigación(2026-04-28) Reyes Jordan, Diego Fernando; Vasquez Rivera, Sofía; Heiler, Lozada Ramos; Jorge Enrique, Daza Arana (Directores)Pulmonary tuberculosis is a public health challenge where the loss to follow-up limits its control given the scarce local evidence about its determinants and sequelae, which is why this study sought to identify the factors associated with treatment abandonment and explore the resulting functional disability in patients from a public hospital in Palmira, Colombia, during the 2021-2025 period. Through a retrospective observational study with an analytical case-control approach that included adults diagnosed between January 2021 and September 2025, subjects with loss to follow-up were compared against those who completed the process, additionally evaluating functional disability in a subsample using the WHODAS 2.0 instrument applied through telephone interviews. Of 192 patients analyzed, 18.5% presented loss to follow-up, a phenomenon that was significantly linked to homelessness, psychoactive substance use, limited family support networks, and occupational impact, while religion acted as a protective factor; likewise, in the subsample the prevalence of disability was 23.0%, with notable differences in cognitive and social domains between the studied groups. In conclusion, adherence to antituberculosis treatment is conditioned by critical psychosocial determinants and the presence of persistent functional disability after the disease highlights the urgency of implementing comprehensive care models, making it fundamental to combine social support with systematic functional evaluation to mitigate follow-up barriers and improve the quality of life of those affected by this pathology in the regional context.Item Trastorno Neurológico Funcional: Mapeo de la evidencia sobre el diagnóstico clínico, revisión de alcance (2020 - 2025)(2026-04-28) Naranjo Zapata, Jhon Hamilton; Quimbaya Colonia, Angélica María; Rojas Arce, Paola Andrea; Lilia Julieta, Castro Penagos (Director)Functional neurological disorder (FND) is a frequent neuropsychiatric condition characterized by neurological symptoms that generate significant disability and a high utilization of health services, whose diagnosis usually represents a challenge since it has traditionally been based on the exclusion of other organic diseases. With the objective of mapping the scientific evidence on the clinical diagnosis of FND, a scoping review was conducted through a search in the PubMed, Springer, ScienceDirect, Clarivate, and Scopus databases, where from an initial total of 27,096 identified records, finally 8 studies met the inclusion and relevance criteria for the topic. The findings of this search highlight the importance of positive clinical signs, as well as innovation in evaluable signs, tools, patterns, and other evident manifestations in the evaluation of these patients, concluding that the evidence supports this diagnostic approach, which can favor the early recognition of the disorder, thus contributing to improving clinical practice.Item Perfil microbiológico y de susceptibilidad antimicrobiana de bacterias aisladas en infecciones urinarias en población pediátrica atendida en una IPS de alta complejidad durante el período 2020-2025 - Investigación(2026-04-28) Montoya Beltrán, Laura Valentina; Morales Mosquera, Nicol Andrea; Rendón Machado, Christopher Jhoan; Mónica Alexandra Gil Artunduagua (Directora)The urinary tract infections (UTI) are one of the most frequent bacterial diseases in the pediatric population worldwide, representing one of the main causes of visits to the emergency department due to the risk of complications, so the objective of this observational cross-sectional study was to identify the main uropathogenic microorganisms and their antimicrobial resistance pattern in pediatric patients treated at the Clínica Santa Bárbara in Palmira, Valle del Cauca, during the period 2020 to 2025. Data from 182 patients were included, where the most common profile were preschool to school-age girls (74.2% women, median age of 3 years). Escherichia coli was the most frequently isolated uropathogenic microorganism with 82.5%, finding antimicrobial resistance patterns against commonly used antibiotics where the most identified is BLEA (20.3%) followed by IRT (19.2%), in addition to reporting 44.6% and 33.9% resistance to trimethoprim/sulfamethoxazole and quinolones, respectively. In conclusion, there is evidence of a worryingly high resistance to first-generation cephalosporins or lower spectrum antibiotics of up to 41.8%, as well as high rates for trimethoprim/sulfamethoxazole and quinolones, findings that suggest the need to rethink the empirical treatment for urinary tract infection in pediatrics.Item Hipoparatiroidismo primario y síndrome de FARH: Reporte de caso(2026-04-28) Guillin Baldion, Nafer Andrey; Narvaez Oquendo, Maria Camila; Hurtado Hurtado, Scheyla Valentina; Deving Arias Ramos (Director)Fahr's syndrome is a rare neurological condition that mainly consists of bilateral intracranial calcifications often associated with disorders of calcium metabolism. We present the case of a 60-year-old female patient with no known pathological or surgical history who presented with a seizure episode. On physical examination, there were clinical signs of hypocalcemia, with positive Chvostek and Trousseau signs. Neuroimaging studies demonstrated symmetric intracranial calcifications compatible with Fahr's syndrome. The underlying cause was diagnosed as primary hypoparathyroidism through metabolic evaluation. During hospitalization, management with calcium and vitamin D supplementation was initiated, with adequate clinical evolution and absence of new seizure episodes. This case highlights the importance of considering phosphocalcic metabolism alterations in patients with intracranial calcifications and neurological manifestations, since their identification allows guiding treatment and follow-up, improving their prognosis.Item Asociación entre la gravedad de la exacerbación aguda de la enfermedad pulmonar obstructiva crónica y las complicaciones cardiovasculares a 30 días en pacientes hospitalizados en el Hospital Raúl Orejuela Bueno(2026-04-29) Restrepo Cortes, Alejandra; Sanclemente Valencia, Alejandro; Zuluaga Fernández, María Alejandra; Jonathan Montaño Luna (Director)Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality globally, whose study aimed to analyze the association between acute exacerbation of COPD and the incidence of major adverse cardiovascular events (MACE) during the 30 days following hospital discharge. An observational, analytical, retrospective cohort methodological design was structured based on 38 adult patients with a confirmed clinical diagnosis of COPD who required hospitalization at the Hospital Raúl Orejuela Bueno (Palmira), where the primary composite outcome (MACE) at 30 days reached a global incidence of 50.0%. Subjects who presented with an exacerbation classified as severe exhibited a significantly higher frequency of MACE (71.4%) in contrast to those who experienced moderate or mild episodes (23.5%), documenting a statistically and clinically significant association (OR 8,1; IC 95% 1,56-47,6; p = 0,004), while, in the comorbidity analysis, preexisting heart failure demonstrated the highest magnitude association with the occurrence of MACE (OR 38,0; IC 95% 4,1-351; p = 0,001). In conclusion, the severity of acute exacerbation of COPD consolidated as a relevant clinical marker for short-term cardiovascular risk prediction, categorically supporting the imperative need to establish strict cardiovascular surveillance protocols and rigorous risk stratification strategies during the vulnerability window of the post-exacerbation period.Item Evaluación del conocimiento sobre obesidad y nutrición en estudiantes de medicina de la Universidad Santiago de Cali, seccional Palmira, 2026(2026-04-29) Mena Urrutia, Laura Isabel; Jonathan Montaño Luna (Director)The present study aimed to evaluate the level of knowledge about obesity and clinical nutrition in medical students of the Universidad Santiago de Cali (Seccional Palmira), as well as to explore its correlation with self-reported dietary practices and curricular advancement. An observational, descriptive, and cross-sectional methodological design was executed. Data collection was performed through a survey that evaluated sociodemographic domains, theoretical constructs, dietary patterns, and clinical perceptions. Statistical analysis was done using descriptive analysis and the application of the prueba x^2 test, establishing a statistical significance threshold of p < 0,05. The maximum success rates (96.7%) corresponded to the holistic diagnostic approach and multimodal therapeutic management, while the population risk stratification recorded a lower performance (76.7%). The null inference did not yield significant associations between the cognitive domain and the academic semester (p = 0,126), the dietary behavioral pattern (p = 0,508), the consultation of indexed literature (p = 0,439), or the perceived clinical self-efficacy (p = 0,854). It is concluded that, although the student cohort possesses an outstanding conceptual heritage, a marked cognitive-behavioral asymmetry remains in their nutritional habits.Item Opciones Terapéuticas en Paragangliomas Yugulotimpánicos: Revisión de Alcance de la Evidencia Publicada entre 2021 y 20261(2026-04-28) Cleves Marulanda, Juan Manuel; Julián Andrés Delgado Sánchez (Director)Aquí tienes el resumen narrativo en un solo párrafo y en inglés, manteniendo la idea principal y utilizando estrictamente las palabras de tu texto original: Jugulotympanic paragangliomas are rare neuroendocrine neoplasms of the temporal bone, characterized by slow growth but with a marked potential for local invasion and a close relationship with critical neurovascular structures. This complexity explains the current controversy regarding the balance between tumor control and functional preservation. The present study identified and compared, through a scoping review, the therapeutic options used in adult patients with this pathology and their oncological and functional outcomes in the literature published between 2021 and 2026. The search was conducted in PubMed/MEDLINE, Scopus, Web of Science, and ScienceDirect, following the JBI methodological framework and reported according to PRISMA-ScR. Out of 787 identified records, 300 duplicates were removed; after screening, 47 full texts were evaluated and 34 studies were included. In early tympanic and tympanomastoid tumors, surgery showed high rates of complete resection, low recurrence, and a favorable functional profile, with frequent resolution of pulsatile tinnitus. In advanced jugular and jugulotympanic tumors, fractionated radiotherapy and stereotactic radiosurgery demonstrated high tumor control with lower neurological morbidity, consolidating as first-line alternatives or as part of multimodal schemes. Adjuvant strategies (preoperative embolization, endoscopic approaches, laser, and carotid stent) were identified as complementary tools in selected cases. Quality of life was the least standardized outcome. In synthesis, the evidence supports a stratified therapeutic approach in which surgery and radiotherapy/radiosurgery act as complementary strategies, whose optimal indication depends on the anatomical and functional risk of each case.Item Ejercicio físico en la prevención de preeclampsia: parámetros de prescripción, reserva cardíaca materna y desenlaces perinatales adversos. Revisión de alcance.(2026-04-28) Berrio Martínez, Valeria; Gómez Villegas, Juan José; Orlando Arboleda Zúñiga (Director)Preeclampsia constitutes one of the main causes of maternal morbidity and mortality in Colombia and worldwide, positioning maternal cardiac reserve as a possible intervention target before an insufficient maternal hemodynamic adaptation. The objective of this study was to map the available evidence on the structured prescription of physical exercise as a preventive intervention in women at risk of preeclampsia, characterizing its prescription parameters and its effects on maternal cardiac reserve and adverse perinatal outcomes, for which a scoping review was conducted following the JBI methodology and PRISMA-ScR guidelines by consulting PubMed and SciELO databases, finally including 23 unique studies published between 2016 and 2026 for narrative synthesis. The results showed that the most consistently evaluated type of exercise was moderate-intensity aerobic exercise, with a frequency of three to five weekly sessions of 20 to 60 minutes, being associated with a reduction in peripheral vascular resistance, a 20 to 35% reduction in preeclampsia risk, and without increasing the risk of preterm birth or low birth weight; likewise, two maternal hemodynamic phenotypes —hypodynamic and hyperdynamic— were identified, without any study evaluating differentiated prescription parameters according to phenotype. In conclusion, structured physical exercise of moderate intensity represents a safe and effective preventive intervention with the potential to reduce the incidence of preeclampsia through the optimization of maternal cardiac reserve, with a critical evidence gap existing regarding differentiated prescription parameters according to maternal hemodynamic phenotype, constituting the most urgent priority for future research.Item Comparación del Rendimiento Diagnóstico De la Adenosina Desaminasa para el diagnóstico de Tuberculosis en fluidos corporales de individuos VIH positivos y negativos: Revisión Sistemática.(2026-04-28) Villarreal Osorio, Isabella Maysuri; Jorge Enrique Daza Arana, Heiler Lozada Ramos (Directores)Tuberculosis (TB) continues to be one of the infectious diseases with the greatest impact on global public health, with the TB/HIV coinfection constituting a significant clinical challenge, a context in which adenosine deaminase (ADA) has consolidated as a useful biomarker in the diagnosis of extrapulmonary tuberculosis, although its diagnostic performance could be compromised in patients with advanced immunosuppression. To analyze the variation of ADA values in patients with TB coinfected with HIV compared to those without coinfection, a systematic review was carried out in accordance with the PRISMA guide guidelines in verified international databases, finally including 16 studies that met the established criteria after evaluating their methodological quality. The results of these investigations, coming from six countries with high prevalence, showed a significant heterogeneity where, in approximately 70% of the studies, ADA values were lower in patients with TB/HIV coinfection, particularly in those with low CD4 lymphocyte counts; despite this variability, the majority reported a sensitivity and specificity greater than 80%, especially in pleural, peritoneal, and pericardial TB. In conclusion, ADA maintains an adequate diagnostic performance in TB, even in the presence of HIV coinfection; however, its levels tend to be lower in immunocompromised patients, so the interpretation of the results must consider the immunological status of the patient and the type of fluid analyzed, recommending the standardization of cut-off points and the unification of analytical methodologies.Item Efectividad de la telesalud en pacientes adultos que sufren obesidad intervenidos con programas orientados al control del peso sobre la modificación de los biomarcadores metabólicos y los cambios en la composición corporal: revisión sistemática y metanálisis(2026-04-28) Villegas Paz, Eimi Sarin; Camacho Cordoba, Geraldine; Monar Gutierrez, Shirley Dayhana; Alejandro Segura Ordoñez (Director)A systematic review with meta-analysis was conducted following the PRISMA 2020 guidelines to evaluate the effectiveness of telehealth-based interventions in adults with obesity, including nine studies published between 2016 and 2023 in PubMed, Scopus, Web of Science, Ovid, and EBSCO that evaluated body weight, BMI, HbA1c, lipid profile, blood pressure, and treatment adherence. The results showed that in the short term (1–12 weeks) no significant differences were observed, but in the periods of 2–6 months and 3–12 months, significant reductions in body weight and a decrease in BMI were evidenced; furthermore, HbA1c showed significant decreases in the medium term, changes in the lipid profile were variable, and significant reductions in blood pressure were observed, as well as greater treatment adherence in the intervention groups. It is concluded that interventions with telehealth tools are effective for the reduction of body weight and BMI, especially in the medium term, contributing to glycemic control, blood pressure, and treatment adherence, representing a viable strategy in the comprehensive management of obesity, conditioned by the duration of the intervention and the intensity of the follow-up.Item Factores clinicos asociados a la decision de intubacion orotraqueal en pacientes con intoxicación aguda en sala de urgencias. revision de alcance. 2020-2025.(2026-04-28) Melo Suárez, Gabriel; Enriquez Meneses, Yuliana; Anderson Fabian Mondragon (Director)Acute poisoning represents a frequent cause of consultation in emergency departments and, in severe cases, may require advanced airway management; however, clearly defined standardized criteria to guide the decision for orotracheal intubation in these patients are still lacking. The objective of this scoping review was to identify the clinical factors associated with this decision in the emergency context. A review was conducted following the PRISMA-ScR guidelines, including original observational and experimental articles; the information was extracted using an Excel matrix and analyzed through a descriptive synthesis. Thirty studies were included, in which the clinical factors most frequently associated with the decision to intubate were impaired level of consciousness (Glasgow $\le$ 8) and respiratory compromise (O2 saturation below 90% persisting despite nasal cannula therapy, bradypnea, apnea, hypoxemia). Consequently, the decision for intubation in patients with acute poisoning in the emergency department is mainly based on neurological and respiratory compromise, providing a useful clinical framework for decision-making, although studies with greater methodological rigor are required to establish more standardized criteria.Item Implicaciones Terapéuticas En El Manejo De Diabetes Mellitus Tipo 2 En Relación Con La Microbiota Intestinal - Revisión De Alcance(2026-04-28) Molina López, Lizeth Tatiana; Erazo Vásquez, Andrea Elizabeth; Valencia Castañeda, Dayana Alejandra; Pedro Molano (Director)Objective: to analyze recent evidence on the relationship between gut microbiota and type 2 diabetes mellitus, with emphasis on its therapeutic implications. Methodology: a literature scoping review was conducted according to PRISMA 2020, with a search in PubMed, Scopus, ScienceDirect, Springer, Sage Journals, Nature, Dialnet, Frontiers, and The Lancet; publications in English, Spanish, or Portuguese, in humans, between 2020 and 2025, corresponding to systematic reviews, meta-analyses, and randomized clinical trials, were included. Results: 89 records were identified and 25 studies were included in the qualitative synthesis, of which 15 were systematic reviews or meta-analyses and 10 were randomized clinical trials. The evidence showed that gut dysbiosis is associated with low-grade inflammation, insulin resistance, and alterations in glucolipid metabolism. Interventions targeting the microbiota, especially probiotics, synbiotics, prebiotics, and dietary fiber, showed favorable effects on fasting glucose, HbA1c, HOMA-IR, and other metabolic markers, although with heterogeneity among strains, doses, and duration. Conclusion: the gut microbiota constitutes a promising adjuvant therapeutic target in type 2 diabetes mellitus; however, the interpretation of the findings must be made with caution due to the methodological and clinical variability of the available studies.Item Análisis Comparativo de Factores Asociados a Infección por Virus del Papiloma Humano (VPH) en Adolescentes: Colombia Frente a Latinoamérica – Revisión de la Literatura(2026-04-29) Marmolejo Orozco, Alexa; Méndez Ayala, María José; Troyano Ramírez, Camila; Johanna Andrea García Clavijo (Directora)Cervical cancer is the fourth most common cancer in women worldwide, mainly caused by persistent infection with oncogenic types of human papillomavirus (HPV), with adolescents being an especially vulnerable population due to early onset of sexual life, limited knowledge, and risk behaviors. OBJECTIVE: To analyze the scientific evidence on risk factors related to HPV transmission in adolescents in Latin America and Colombia. METHODOLOGY: Literature review following PRISMA guidelines through a search in Scopus, Dialnet, ScienceDirect, Elsevier, and Pubmed for articles published between 2020 and 2025 on risk factors associated with HPV transmission in Latin American adolescents, assessing quality with the PEDro scale and constructing comparative tables of sociodemographic factors, sexual behaviors, and access to primary prevention. RESULTS: The population was predominantly women of reproductive age from urban areas, with a medium-low socioeconomic level, partial access to health services, and scarce sociodemographic and psychosocial information; risk behaviors such as early sexual debut and multiple partners were identified, along with low vaccination coverage. CONCLUSIONS: Research was mainly descriptive, with scarce inclusion of psychosocial factors, identifying risk behaviors and incomplete and heterogeneous information, with low vaccination coverage, which evidences the need for improvement in both registry quality and prevention strategies.Item Comparación De La Eficiencia Clínica De Los Fármacos Biológicos Frente A Los Inhibidores Jak En Adultos Con Diagnóstico De Artritis Reumatoide: Revisión De Alcance(2026-04-27) Valencia Rodas, Valentina; Barreto Lopez, Maria Jose; Rosas Caicedo, Andrea Catherine; Anderson Mondragón (Director)Background: Rheumatoid arthritis is a chronic inflammatory disease of autoimmune origin that causes progressive joint damage, functional impairment, and decreased quality of life, whose treatment is based on conventional or synthetic disease-modifying antirheumatic drugs (DMARDs), biologic drugs (BD), and Janus kinase (JAK) inhibitors. Because doubts persist about their clinical efficacy, the objective of this scoping review is to evaluate the clinical efficiency and efficacy of biologic drugs and JAK inhibitors in adults diagnosed with rheumatoid arthritis based on a literature analysis of clinical trials and observational studies, examining symptom reduction and improvement in laboratory parameters to generate valid results allowing the evaluation of clinimetry and health improvement. Method: A systematic literature search was conducted in scientific databases, including randomized clinical trials, systematic reviews, and observational studies published in recent years, such as Scopus, PubMed, ScienceDirect, MEDLINE Plus, and Google Scholar, among others, also consulting Colombian and Latin American literature in databases provided by the Universidad de Santiago de Cali.Item Hemoperitoneo postparto secundario a la rotura posterior del útero: Reporte de caso(2026-04-28) Duran Montoya, Eileen Mariana; García Guendica, Ana María; Jaramillo Quigua, Yeris Michelle; Pedro Andrés Molano Agudelo (Director)The rupture of the posterior wall of the uterus associated with hemoperitoneum in the postpartum period is a rare but life-threatening obstetric complication, with an unspecific clinical presentation that can delay its diagnosis, whose incidence in an unscarred uterus represents about 7.3% of cases, where factors such as multiparity, advanced maternal age, history of cesarean section, and fetal macrosomia increase the risk. We present the case of a 36-year-old patient, G5P2C1A2, at 38 weeks, taken to cesarean section due to fetal macrosomia (newborn of 4100 g), who readmitted at 48 hours with abdominal pain, vaginal bleeding, hypotension, tachycardia, anemia, and leukocytosis; initially the ultrasound was inconclusive, but upon identifying free intraperitoneal fluid, an exploratory laparotomy was performed, finding approximately 3000 cc of hemoperitoneum and rupture of the posterior uterine wall, which was resolved with surgical repair and transfusional management with favorable evolution. This case evidences that puerperal hemoperitoneum can present atypically, so the main lesson is to maintain a high clinical suspicion in the presence of persistent abdominal pain associated with hemodynamic instability, even when initial studies are inconclusive.Item Discinesia ciliar primaria en pediatría, revisión sistemática de literatura entre 2021 y 2025(Universidad Santiago de Cali, 2026-04-28) Cardenas Orozco, Johan Camilo; Rivera Claros, Alejandra; Felipe Salcedo Libreros (Director)Primary ciliary dyskinesia (PCD) is a rare genetic disease characterized by dysfunction of motile cilia and recurrent respiratory manifestations such as chronic sinusitis, persistent otitis media, and progressive bronchiectasis, also presenting laterality alterations such as situs inversus. Despite advances, diagnosis remains delayed in the pediatric population due to low prevalence, clinical variants, and limited access to specialized tests. The objective was to perform a systematic literature review following PRISMA guidelines to review the scientific evidence published between 2021 and 2025 on the sociodemographic and clinical characteristics of pediatric patients with PCD. The search was conducted in biomedical databases such as PubMed/MEDLINE, Scopus, and Web of Science using MeSH and DeCS terms, including original clinical studies in English and Spanish on pediatric patients (0 – 18) with a diagnosis of PCD that reported variables such as age, gender (male - female), ethnicity (Caucasian, Asian, Afro-descendant, Hispanic), and clinical manifestations, and excluding studies without demographic reports, publications without peer reviews, or without full-text access.Item Efectividad Del Mogamulizumab En El Control De Sintomas Y Avance De La Paraparesia Espástica Tropical Por Htlv-1. Revisión Sistemática De Literatura.(Universidad Santiago de Cali, 2025) Pabón Bernal, Daniela Sofia ; Portillo Rodríguez, Steeven ; Vélez Cárdenas, Catalina; Moyano Tejada, Pablo Andres (Director)The Human T-Lymphotropic Virus (HTLV), primarily types 1 and 2, affects 15 to 20 million people globally through breastfeeding, sexual contact, and contaminated blood, with Colombia reporting 1,398 infected donors between 2015 and 2020. While HTLV-1 and HTLV-2 share receptors like NRP1 and GLUT1, their distinct regulatory proteins and genes lead to different clinical outcomes, specifically HTLV-1’s association with adult T-cell leukemia and HAM/PET. Although conventional treatments fail to reduce viral load or slow progression, the monoclonal antibody Mogamulizumab shows potential in eliminating infected cells despite limited evidence and side effects like skin rashes, necessitating further systematic reviews to guide its use in HAM/PET management.Item Primer reporte en Colombia de una infección del tracto urinario causada por Kluyvera ascorbata con un patrón de resistencia a AmpC: reporte de caso.(Universidad Santiago de Cali, 2025) Valencia Ibarguen, Johnny; Lizcano Martinez, Yamil (Director)