Microbiología
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Browsing Microbiología by Author "Ante Vasquez, Cristian Geovany"
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Item Estudio de la interacción de un péptido catiónico derivado de la Cecropina-D Gallería mellonella con sistemas de modelos de membranas multilaminares que muestran similitud con las membranas bacterianas(Universidad Santiago de Cali, 2021) Ante Vasquez, Cristian Geovany; Vergara Moreno, Esmeralda; Oñate Garzón, Jose Fernando (Director); Polo Cerón, Dorian (Codirector)Antimicrobial peptides are of great importance in many living organisms, since they are part of the innate immune system, performing the role of effectors in defense against infectious agents. These are found in a great diversity of living beings, from which a great variety of these molecules have been isolated, such as CECROPINA-D from Galleria mellonella; the synthetic peptide M1 of 39 amino acids that has been obtained from the sequence of Cecropina Galleria mellonella, is a cationic homologue derived from the originally extracted peptide. It is known that the antimicrobial action of these molecules is due to the attraction of opposite charges that occur between the microbial membrane with an anionic charge and the peptide with cationic charge, therefore, it causes alterations in the change of phase resulting in an increase of the permeability of the membrane. However, there is not enough information about the mechanisms of action that peptides must cause the phase change of the membrane; In this work, the effect of the peptide on the thermotropic behavior of membrane models that simulate those of bacteria, consisting of DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine) and DMPG (1,2 -Dimyristoyl-sn-glycero-3- phosphorylglycerol), respectively. Furthermore, an in-silico analysis allows us to recognize the peptide-membrane molecular interactions necessary to understand this effect.