Microbiología
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Browsing Microbiología by Author "Amú Márquez, Ana María"
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Item Caracterización in silico de la interacción entre Eudragit E-100 y PAM-18 Na2 con la proteína de unión a penicilina (PBP2a) de Staphylococcus aureus resistente a la meticilina(Universidad Santiago de Cali, 2022) Amú Márquez, Ana María; González Bermúdez, Astrid Viviana; Oñate Garzón, José Fernando; Liscano Martínez, YamilAntimicrobial treatment options against methicillin-resistant Staphylococcus aureus (MRSA) are increasingly limited. MRSA strains are resistant to β-lactam antibiotics by acquiring the mecA gene, which codes for the penicillin-binding protein (PBP2a), which has very little affinity with these β-lactamics. Previous studies have shown that the use of functionalized nanoliposomes with ampicillin-laden particles can improve the antimicrobial activity of ampicillin in resistant strains of S. aureus. However, the biological mechanism of these systems has not yet been adequately elucidated. Therefore, this work characterized the interaction of two polymers, Eudragit E-100 and PAM-18 Na used for the recovery of the antibiotic activity of ampicillin against MRSA strains with PBP2a of Staphylococcus aureus, making use of bioinformatic tools. For this, molecular coupling studies were carried out at the active site of PBP2a, evaluating the monomeric units of both polymers in a neutral and ionized form as well as with the antibiotic ampicillin. The results showed that ampicillin and monomeric units of Eudragit and PAM18 Na described a slight free energy binding to the PBP2a protein.