Medicina

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Colestasis en el embarazo, Oportunidad y facilidad de diagnóstico en Latinoamérica: Revisión de alcance
(Universidad Santiago de Cali, 2024) Aponza Herrera, María Alejandra; Eraso Montilla, Juan José; Solarte Bacca, Santiago; Morales Chaves, Renan Orlando (Director)
Intrahepatic cholestasis of pregnancy (ICP) is the most common and reversible liver disease, with low incidence but high risk of fetal complications. Timely diagnosis is required; The gold standard test is the quantification of bile acids, which is difficult to perform. METHODOLOGY: Scoping review based on the search in Pubmed, sciencedirect and scopus databases, which answers the question: What is the opportunity and ease of diagnosis in Latin America of intrahepatic cholestasis in pregnancy? RESULTS: 22 articles, published in Peru (36.3%), Uruguay and Argentina (13.6% each), Mexico, Colombia and Ecuador (9%), pruritus and jaundice are present in 80% of cases, along with elevated liver function, only 55% of the studies have an evaluation of total bile acids. CONCLUSION: The diagnosis of ICP is made from the clinical presentation and confirmation of elevated liver tests; there is still little diagnostic opportunity from the quantification of total bile acids, which does not coincide with the advances and recommendations of CPGs, testing is recommended given the evidence of the existing elevation between ABT levels and perinatal complications