Química Farmacéutica
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Browsing Química Farmacéutica by Author "Angarita Rodríguez, Elizabeth"
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Item Implementación de una estrategia de medicamentos trazadores para la detección de reacciones adversas a medicamentos (RAM) en la Clínica Cali(Universidad Santiago de Cali, 2025-12-04) Narváez Hoyos, Maria Fernanda; Angarita Rodríguez, Elizabeth; Echeverry Martínez, Jhon Jairo (Director)The study aimed to implement an active pharmacovigilance strategy using tracer medications to strengthen the detection of adverse drug reactions (ADRs) at Clínica Cali, to overcome the limitations of underreporting in the spontaneous reporting system. A quasi-experimental before-and-after study was conducted, comparing the baseline period (January-March 2025) with the intervention period (April-July 2025). A list of tracer medications was selected for their ability to act as indirect indicators of potential adverse reactions. The strategy consisted of a weekly review of dispensations in the institutional system (SIIS) and a causality assessment using the Naranjo algorithm. Data were analyzed using descriptive statistics and Fisher's exact test to compare ADR rates between periods. The results demonstrated a significant increase in ADR detection, increasing from a rate of 1.94 to 9.58 per 1,000 hospitalized patients (p = 0.00026; OR = 4.99). Twenty-four ADRs were identified using the active strategy, compared to 7 reported using traditional methods. Most ADRs were probable (87.5%), with dipyrone being the most implicated drug and rash being the most frequent reaction. The implementation of active pharmacovigilance with tracer drugs proved to be a highly effective and viable strategy for significantly increasing ADR detection in a tertiary care hospital in Colombia. This methodology stands as an essential tool for strengthening institutional patient safety programs and generating local evidence for clinical and therapeutic decision-making.