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Universidad Santiago de Cali
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Evaluación antimicrobiana de colistina encapsulada con nanoliposomas recubiertos de quitosano de mediano peso molecular, frente a bacterias gramnegativas sensibles y multidrogoresistentes
(Universidad Santiago de Cali, 2021) Betancourt Ayala, Yeiston; Oñate Garzón, Jose Fernando; Rivera Sánchez, Sandra Patricia
Colistin is a last resort antibiotic which has been reimplemented in clinical practice in order to combat infections by gram-negative and multidrug-resistant bacteria, however, this antibiotic has lost affinity towards this type of bacteria, being caused by the increase and dissemination of strains resistant to this polypeptide. In this work, the antimicrobial activity of colistin encapsulated in nanoliposomes coated with chitosan of medium molecular weight was evaluated against the sensitive Escherichia coli strains, and Pseudomonas aeruginosa sensitive and multidrug resistant strains. Physicochemical properties such as particle size, polydispersity index and zeta potential were determined using Zetasizer nano ZSP. The results for the chitosan-coated systems showed changes in size (from 461.5 nm uncharged to 322.2 nm with colistin), polydispersity index (from 0.219 unloaded to 0.449 with colistin), and zeta potential (from -2.1 mV unloaded). at 15.0 mV with colistin). After encapsulating the colistin, the minimum inhibitory concentration (MIC) of the formulations was determined by the broth microdilution method for P.a ATCC (27853), sensitive population P.a and resistant P.a. For antimicrobial activity, resistance was obtained in strain No. 2, decrease in minimum inhibitory concentration in strain No. 1, sensitivity in strain No. 3 and population strain (W.t).
Sistema de información y atención al usuario "SIAU", como mecanismo que permite a las instituciones en salud mejorar la calidad de los servicios prestados
(Universidad Santiago de Cali, 2020-07-16) Urrutia Banguero, Luz Adriana; Kuzner Alvarado, Armando
In Colombia, it has been proposed to improve both the coverage and the quality of the health system. Progressively it has been improving in these two aspects, different tools and guidelines have been adopted to achieve continuous improvement. The objective of this document is to analyze how the User Information Service (SIAU) allows Health Service Provider Institutions (IPS) to improve the quality of the services provided. At the methodological level, a descriptive study with a qualitative approach was used where, through the documentary review, different experiences in which the SIAU has been used to improve user service are analyzed. According to the evidenced results, it is possible to identify that this system provides relevant information for improvements to be adopted through contact with patients or users of health institutions. In order to materialize these improvements, it is essential that management or management take into account the different PQRS, analyze them and formulate specific actions to correct shortcomings. In the long term, the SIAU contributes to the consideration of different elements that constitute the experience of access to health services, since some are related to the contact between officials and users, infrastructure, communication channels, among others, that sometimes go unnoticed.
Efectos del cannabis medicinal relacionado al dolor y al cuidado paliativo
(Universidad Santiago de Cali, 2024-06-07) Villado Garcia, Alexander; Rivera Romero, Viviana
Cannabis is now used medicinally in palliative care to relieve symptoms and improve quality of life in patients with different diseases. Its use is based on reports of analgesic, antiemetic, orexigenic and anxiolytic effects. These effects are attributable to exogenous manipulation of the endocannabinoid system by the biologically active compounds of the plant.
Terapia fágica en la era de la multirresistencia bacteriana. Una revisión sistemática
(Universidad Santiago de Cali, 2021) Pantoja Camacho, Lady Daniela; Martinez Martinez, Edgar Andrés; Aranaga, Carlos Andrés; Falco Restrepo, Aura Dayana
Antibiotics have played an important role in the treatment of infections caused by bacteria. However, the high rates of resistance currently reported towards these drugs represent a public health problem. Bacteriophages constitute an alternative to mitigate the resistance to the use of antibiotics because they are capable of infecting and lysing bacteria in a specific way, without these processes being affected by the changes that led to the acquisition of antibiotic resistance. Therefore, bacteriophages are suitable candidates to exert biocontrol in bacteria of clinical interest. To determine whether phage therapy has been successful in the treatment of infections caused by multidrug-resistant bacteria, this systematic review of scientific literature was carried out. Using PRISMA methodology, three scientific databases were selected: Pubmed, Science Direct, and Google Scholar, from which 25 research articles and clinical cases from the last 10 years that met the inclusion criteria were included. A review of the information from each study was carried out and it was determined that most of the infections were caused by bacteria such as S. aureus, K. pneumoniae, and A. baumanii. The results indicate that the era of multi-resistance to antibiotics promoted the increase in therapy with bacteriophages in the last three years. Likewise, in 92% of the cases studied, its application was successful. Even though positive results have been obtained in the application of phage therapy, more studies related to pharmacokinetics are needed, as well as to demonstrate more safety concerning its administration, to standardize the treatment to be used according to the infection to be treated.
Establecimiento de las condiciones de compostaje utilizando microorganismos eficientes y desechos orgánicos producidos en restaurantes de la Universidad Santiago de Cali
(Universidad Santiago de Cali, 2021) Cosme Perlaza, Jefrid Leandro; Molina Rada, Ananda Esther; Quijano, Silvia Andrea; Falco, Aura
The Santiago de Cali University produces a wide variety of wastes that are mostly organic and, currently, are not used properly. Composting emerges as an alternative that transforms solid waste into organic fertilizer for the soil, however, this process usually takes several months. The use of efficient microorganisms is an option to optimize the time of the composting process. The objective of this work was to establish the conditions for composting organic waste produced in restaurants of the Universidad Santiago de Cali, using efficient microorganisms and the Autonomous Composting System SAC-2250. Initially, the standardization of the conventional composting process was carried out, evaluating four treatments with different amounts and combinations of substrate. The results indicate that treatment 1 (3 parts of organic matter per 1 of sawdust) had the best behavior compared to that reported in the literature (the duration of the process is 45 days). Subsequently, three efficient microorganisms identified as Klebsiella oxytoca, Sphingomonas paucimobilis and Pantoea spp were isolated and inoculated in treatment 1. The results indicate that the inoculum reduced the composting process in 20 days, when compared with the control cell. The proper management of the organic waste will significantly reduce the accumulation of them, decreasing the environmental impact and therefore the rate of cleanliness in the institution, in addition it faces an aesthetic and landscape component in the community Santiaguina.