Presencia y propagación del gen mcr-1 en bacterias Gramnegativas desde el enfoque One Health: una revisión sistemática

Avila Zambrano, Lesly Tatiana

Presencia y propagación del gen mcr-1 en bacterias Gramnegativas desde el enfoque One Health: una revisión sistemática

dc.contributor.advisor	Aranaga Arias, Carlos Andrés(Director)
dc.contributor.advisor	Martínez Garay, Carlos Andrés(Director)
dc.contributor.author	Avila Zambrano, Lesly Tatiana
dc.creator.degree	Trabajo de Grado para optar al título de Microbióloga
dc.date.accessioned	2026-09-09T20:27:18Z
dc.date.available	2026-09-09T20:27:18Z
dc.date.issued	2026-06-26
dc.description	Antimicrobial resistance is a growing threat to global public health, especially due to the emergence of resistance mechanisms to last-line antibiotics such as colistin. The plasmid-mediated mcr-1 gene has been identified as a key determinant in the spread of resistance in Gram-negative bacteria, with clinical, veterinary and environmental implications . The objective of this study was to analyze the available evidence on the presence and dissemination of the mcr-1 gene in Latin America, through a systematic review of the scientific literature. A search was conducted in the PubMed, Scopus, SciELO and LILACS databases, including studies published between 2015 and 2025 that reported the detection of the gene in Gram-negative bacteria. Seven studies were selected for qualitative analysis. The results showed a heterogeneous distribution of the gene in the region, with a predominance in Escherichia coli and frequent association with IncI2 and IncX4 plasmids. Its presence was identified in human and animal samples, while studies in environmental matrices were limited. These findings highlight the importance of mobile genetic elements in the spread of colistin resistance and show the need to strengthen surveillance under a One Health approach. However, the limited number of studies and methodological heterogeneity restrict the generalizability of the results. In conclusion, it is necessary to expand research in the region, especially in the environmental component, as well as to standardize detection methods to improve the understanding of the dynamics of mcr-1 gene dissemination.
dc.description.abstract	Antimicrobial resistance is a growing threat to global public health, especially due to the emergence of resistance mechanisms to last-line antibiotics such as colistin. The plasmid-mediated mcr-1 gene has been identified as a key determinant in the spread of resistance in Gram-negative bacteria, with clinical, veterinary and environmental implications . The objective of this study was to analyze the available evidence on the presence and dissemination of the mcr-1 gene in Latin America, through a systematic review of the scientific literature. A search was conducted in the PubMed, Scopus, SciELO and LILACS databases, including studies published between 2015 and 2025 that reported the detection of the gene in Gram-negative bacteria. Seven studies were selected for qualitative analysis. The results showed a heterogeneous distribution of the gene in the region, with a predominance in Escherichia coli and frequent association with IncI2 and IncX4 plasmids. Its presence was identified in human and animal samples, while studies in environmental matrices were limited. These findings highlight the importance of mobile genetic elements in the spread of colistin resistance and show the need to strengthen surveillance under a One Health approach. However, the limited number of studies and methodological heterogeneity restrict the generalizability of the results. In conclusion, it is necessary to expand research in the region, especially in the environmental component, as well as to standardize detection methods to improve the understanding of the dynamics of mcr-1 gene dissemination.
dc.format	application/pdf
dc.format.extent	15 páginas
dc.identifier.citation	Avila Lesly,(2026). Presencia y propagación del gen mcr-1 en bacterias Gramnegativas desde el enfoque One Health: una revisión sistemática [Tesis de pregrado, Universidad Santiago de Cali]. Repositorio Institucional USC.
dc.identifier.uri	https://repositorio.usc.edu.co/handle/20.500.12421/9671
dc.language.iso	es
dc.publisher	Universidad Santiago de Cali
dc.publisher.faculty	Facultad de Ciencias Básicas
dc.publisher.program	Microbiología
dc.pubplace.city	Cali
dc.rights.acceso	Acceso Abierto
dc.rights.cc	Reconocimiento 4.0 Internacional (CC BY 4.0)
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/
dc.source.institution	Universidad Santiago de Cali
dc.source.repository	Repositorio Institucional USC
dc.subject	América Latina
dc.subject	One Health
dc.subject	plásmidos
dc.subject	resistencia antimicrobiana
dc.subject	transferencia horizontal de genes
dc.subject.keyword	Latin America
dc.subject.keyword	One Health
dc.subject.keyword	Plasmids
dc.subject.keyword	Antimicrobial resistance
dc.subject.keyword	Horizontal gene transfer
dc.title	Presencia y propagación del gen mcr-1 en bacterias Gramnegativas desde el enfoque One Health: una revisión sistemática
dc.type	Thesis
dc.type.spa	Artículo de revisión bibliográfica