Medicina - Palmira
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Browsing Medicina - Palmira by Subject "Derrame Pleural"
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Item Síndrome de Gorham Stout en un paciente joven: reporte de caso(Universidad Santiago de Cali, 2024) Angulo Velásquez, Eider Andrés; Ayala Victoria, Fabián Santiago; Legarda Córdoba, Juan Diego; Barahona Rebolledo, Carolina (Directora)Gorham Stout syndrome is a low prevalence bone disease of unknown etiology, characterized by progressive osteolysis, which can manifest at any age, without gender or race predisposition and can affect any part of the skeletal system. Although there are no specific symptoms, diagnostic methods or specific management for this pathology, symptoms such as dyspnea, fever, weight loss associated with osteolysis may occur. A common complication is the development of chylothorax, which occurs in approximately 20% of patients, and is associated with a poor prognosis with a high mortality rate. In this case report, a young adult male patient will be presented who, after several episodes of dyspnea, is diagnosed with chylothorax of unknown cause, and in order to clarify the etiology, diagnostic images such as PET scan and MRI are taken where osteolysis was observed in vertebral bodies and costal arches. The clinical and imaging manifestations and evidence of generalized lymphatic abnormality led to the diagnosis of Gorham Stout Syndrome and its symptoms were managed. Because this entity does not have a protocolized management, treatment with sirolimus and zoledronic acid was tested, achieving a good response to lymphatic proliferation and osteolytic progression. The objective of this case report is to present the clinical and imaging characteristics that guide us to a suspicion of this pathology, because it is considered a diagnostic challenge. Likewise, the management received by this patient opens the possibility of carrying out new medical studies towards a pharmacological therapy.