Química Farmacéutica

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Potencial farmacológico In Silico de péptidos obtenidos por hidrolisis enzimática de la proteína de quinua
(Universidad Santiago de Cali, 2024) Ruiz Beltrán, Daniela; Uzuriaga Perlaza, Laura Mercedes; Oñate Garzón, José Fernando (Director)
Peptides, organic compounds formed by the union of amino acids, are highly valued in the pharmaceutical field due to their high specificity and low toxicity. However, in vivo research with peptides can be costly and slow. In contrast, in silico research offers significant savings in time and costs, allowing a broader search and quick analysis of possible biological activities. The enzymatic hydrolysis of proteins, a process that breaks down proteins into amino acids to reach peptides, is fundamental in this field. Quinoa, a pseudocereal native to the Andes with a high protein content, has been the subject of research for the development of new drugs. Bioinformatics tools, which predict and analyze the breakdown of chemical bonds in biological molecules, are increasingly used to design and select peptides with biological activities. Using the NCBI biology tool, the sequence of the quinoa protein was obtained and bioactive predictions were made in 5119 peptidic sequences obtained by hydrolysis of the actinidin enzyme. The bioactive peptides found can be the basis for developing new drugs to prevent and treat microbial diseases and cancer, thus improving the quality of life of people