Química Farmacéutica

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Guía clínica para disminuir las reacciones negativas de la medicación (RNM) de Amikacina y Gentamicina a través de biomarcadores
(Universidad Santiago de Cali, 2022) Bastidas Perdomo, Jorge Darío; Mondragón Claros, Stephany; Ríos Acevedo, John Jairo; Echeverry, Jhon Jairo
Gentamicin and Amikacin are aminoglycoside antibiotics that target Gram-negative bacteria, but their clinical use is limited due to adverse reactions such as nephrotoxicity and ototoxicity. The objective of this work is to propose a clinical guide for pharmacotherapeutic follow-up that contains biochemical markers as a tool for treatment with Amikacin and Gentamicin. For this, a bibliographic search was carried out in specialized databases such as Taylor & Francis, ScienceDirect and Scopus, in which 1040 documents were found, of which 58 met the selection criteria to carry out the bibliographic review. From the selected documents, it was shown that the most common adverse reactions of aminoglycosides are nephrotoxicity, acute renal dysfunction, hepatotoxicity, ototoxicity, and oxidative stress, in addition, 48 possible biomarkers for these adverse effects were reported and the study of 43 compound organs - protectors to combat them. With the information found, a proposal was made for a clinical guide focused on the detection of adverse reactions induced by Gentamicin and Amikacin, as well as a proposal for their prevention.