Química Farmacéutica

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Efectos en la salud de las interacciones toxicológicas de la cocaína adulterada con Levamisol en Colombia: revisión sistemática
(Universidad Santiago de Cali, 2025-09-29) Medina Melo, Daniela; Ocampo Chaguendo, Dennis Mauricio (Director)
The adulteration of cocaine with levamisole has become a growing global and public health problem in Colombia. This systematic review compiles the health effects derived from this toxicological interaction with levamisole, a veterinary anthelmintic, which increases the volume of the drug and enhances its effects (Solomon, N., et al., 2017). Through a systematic review using databases such as PubMed, Science Direct, Scopus, among others, several clinical cases were compiled, in which the most serious adverse effect was determined to be vasculitis. The results also highlighted that Medellín is the city with the highest number of reported clinical cases due to this toxicological interaction. The contribution of this work is the confirmation of a recurring clinical picture associated with the use of the cocaine- levamisole mixture (vasculitis, agranulocytosis, neutropenia, skin necrosis). However, the search also considered the possibility of finding other less documented adverse effects such as renal, systemic vascular, pulmonary or neurological involvement (described in some international reports).