Química Farmacéutica
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Browsing Química Farmacéutica by Subject "Actividad Enzimática"
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Item Degradación de la psilocina en matrices biológicas: implicaciones toxicológicas forenses y estrategias de detección. Una revisión sistemática(Universidad Santiago De Cali, 2025-11-12) Gordillo Rojas, Sebastián David; Ocampo Chaguendo, Dennis Mauricio (Director)Psilocin, the active metabolite of psilocybin, has gained relevance in forensic toxicology due to its involvement in cases associated with the consumption of psychoactive mushrooms. Its marked chemical and biological instability poses a significant challenge in sample analysis, compromising the detection and quantification of the analyte during preservation and storage. This review aimed to systematically examine the scientific evidence on the factors that affect the stability of psilocin in biological matrices and the strategies used for its proper preservation and detection in forensic contexts. To conclude, the PRISMA statement guidelines were followed in conducting the systematic review. Literature published between 2000 and 2024 was reviewed through searches in PubMed, Scopus, SciELO, Springer Journal, and ScienceDirect. The findings indicate that oxidation, photodegradation, enzymatic activity, and temperature conditions influence the loss of the compound. In addition, the use of preservatives such as ascorbic acid, immediate freezing of samples, and the use of confirmatory techniques such as LC-MS/MS were identified as key measures to reduce degradation and ensure reliable results. In conclusion, the stability and detection of psilocin in matrices such as blood, urine, plasma, and hair depend on strict conditions and standardized protocols that support the validity of forensic toxicology reports.