Química Farmacéutica
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Browsing Química Farmacéutica by Subject "Actividad Antimicrobiana"
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Item Evaluación de la actividad antimicrobiana de colistina encapsulada en nanopartículas de quitosano frente a bacterias extremadamente drogo resistentes(Universidad Santiago de Cali, 2023) Barrera Vélez, Alejandro-Programa Química Farmacéutica ; Pacheco Sierra, Fabian Alexander-Programa Microbiología; Oñate Garzón, José Fernando; Polo Cerón, DorianAntibiotics are a crucial tool in the fight against bacterial infections, both in humans and animals. However, inappropriate use of these drugs has led to bacteria adapting and developing resistance to them, as is the case of P. aeruginosa bacteria, which has multiple ways of resisting even last-line antibiotics, such as colistin. This antimicrobial polypeptide is effective against gram-negative bacteria, but it has nephrotoxic side effects and its efficacy is decreasing against P. aeruginosa. To address this global problem, new techniques have been developed to improve the antimicrobial activity of existing antibiotics. One such technique is the encapsulation of colistin in a natural polymer called chitosan, which improves drug dispersion and increases its activity against bacteria. Recent studies evaluated the performance of chitosan nanoparticles loaded with antibiotics to treat bacterial resistance. The results indicated a significant decrease in bacterial antimicrobial activity, suggesting that the chitosan encapsulation technique could be a promising alternative for the treatment of antibiotic-resistant bacterial infections. To determine this, the performance of chitosan nanoparticles loaded with colistin was synthesized, characterized and evaluated against 2 strains of P. aeruginosa, one sensitive and the other extremely resistant to colistin; obtaining as a result a decrease in the microbial activity (going from growth at colistin concentration of 16 µ/mL to 4 µ/mL) of extremely resistant P. aeruginosa