Química Farmacéutica

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Obtención de carbón activado a partir del desecho de cáscara de coco para la remoción in-vitro de fluconazol en aguas
(Universidad Santiago de Cali, 2024) Coral Palacio, María Alexandra; Jara Sánchez, Laura Yineth; Ciro Monsalve, Yhors Alexander (Director)
The increase of emerging contaminants in drinking water sources represents a significant challenge for public health and the environment. Among these contaminants, fluconazole, an antifungal drug widely used in clinical practice, has been identified as a problematic substance due to its persistence and potential negative impact on aquatic ecosystems. In response to this issue, the use of activated carbons derived from renewable sources has emerged as a promising alternative, with the potential for efficient adsorption of pharmaceutical compounds in aqueous solutions. In this way, adsorbent materials were developed from coconut shell waste by chemical treatment with CaCl2 and H3PO4, the presence of functional groups in their structures was evaluated by the Boehm method, and its adsorption capacity of fluconazole was evaluated at different doses of the drug (6 and 10 ppm), amount of adsorbent material (20 and 50 mg), pH (3.0 and 7.0) and ionic strength (0.5, 1.0 and 1.5 M). Activation with CaCl2 and H3PO4 yielded 10.17% and 16.3% respectively. Boehm titration revealed carboxylic, phenolic, and lactonic functional groups, critical to the fluconazole adsorption process