Química Farmacéutica
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Browsing Química Farmacéutica by Subject "Acné"
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Item Desarrollo y evaluación de una formula cosmética de fabricación artesanal de forma barra jabonosa a base de peróxido de benzoílo para la limpieza y el control del acné(Universidad Santiago de Cali, 2025-09-29) Quintero Hincapié, Henry Mauricio; Ramírez Rico, Diana Carolina; Miller Peluffo, Jhon Alexander (Director); Ciro Monsalve, Yhors Alexander (Director)Benzoyl peroxide has established itself as an effective therapy for the treatment of acne since its discovery in 1929. Currently, it is available in various commercial presentations, such as creams, gels, soap bars and syndets, which allows it to be adapted to the needs and preferences of each user. In order to offer an innovative and practical option, a cosmetic formula in the form of a bar containing 2.5% benzoyl peroxide was developed and evaluated. This product is specially designed for those who seek to care for and maintain adequate control of acne-related disorders, providing an effective and convenient alternative for their daily care routine. Three prototypes of 2.5% benzoyl peroxide sticks were developed using different solvents: 96% potable ethyl alcohol, propylene glycol and glycerin. These prototypes were subjected to extensive analysis to evaluate organoleptic (color, odor and appearance), physicochemical (pH, moisture content and free alkali content) and microbiological quality parameters. Tests were conducted under natural stability conditions, with a temperature of 30 ± 2 °C and a relative humidity of 75 ± 5%, at intervals of 0, 15 and 30 days, using samples packed in cardboard folding cartons. The results showed that there were no significant changes in color, odor, pH, free alkali content or bacterial growth in any of the prototypes. However, slight variations in moisture and texture of the bars were observed. These findings confirmed that, under controlled conditions of temperature (30 ± 2 °C) and relative humidity (75 ± 5%), the benzoyl peroxide cosmetic bar made with alcoholic solvent and packaged in cardboard folding carton maintained its stability during the 30 days evaluated, complying with the established quality parameters. This study supports the viability of this formulation as an effective and stable option for acne care.Item Formulación de crema facial con propiedad antiacné a base del aceite esencial de la flor de caléndula (Caléndula Officinalis)(Universidad Santiago de Cali, 2025) Jaramillo Capote, Juliana Andrea; Illicachi Romero, Luis Alberto (Director); Ciro Monsalve, Yhors Alexander (Director)The present research aimed to formulate a facial cream with actiacné property from hydroalcoholic extracts of Caléndula officinalis; this plant is recognized for its antimicrobial, anti-inflammatory and healing effects. Due to the low yield of the essential oil obtained by steam distillation, changes were made in the methodology to implement three extraction methods: soxhlet, maceration and ultrasound; soxhlet being the highest yield (45.47%). The O/W formulation was subjected to organoleptic, physicochemical and microbiological tests to prove its stability; the results showed that the cream presented an adequate texture and has parameters required to administer in skin with acne; even so, improvements should be implemented since it presents deficiencies in terms of stability, presenting aspects such as a slightly alkaline pH and a high cremated content. This formulation represents the vision of the cosmetics industry regarding the use of natural ingredients.