Facultad de Ciencias Básicas
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Item Caracterización de la fibra larga y corta en variedades comerciales de caña de azúcar y su impacto en el proceso fabril(Universidad Santiago de Cali, 2021-12-04) Polanco Banderas, Roosembert; Larrahondo Aguilar, Jesús Eliecer (Director); Zambrano Salgado, Yesid Fabián (Director)The long fiber / short fiber ratio is used as a characteristic of milling ease of sugar cane in the sugar process. This relationship is carried out by different methods, among which is the mechanical separation of the two main components of the sugarcane fiber called hard fiber (or long) and "pith" (short fiber), after wet digestion in a "Jeffco" type blaster. Different varieties of sugarcane were evaluated considering the content of foreign matter; total fiber content in cane; agro-ecological zones and were associated with observations or problems found in the milling. The relationship between the long fiber and the "pith" (short fiber) determined in this work varies between 0.4 to 1.2, which, is presented as a useful indicator to predict the ease of preparation and milling of new varieties of sugar cane.Item Optimización de la electrogeneración de oxidantes mixtos en la planta de potabilización Rio Nima(Universidad Santiago de Cali, 2022-07-09) García Zúñiga, Jaime; Castro Narvaéz, Sandra Patricia (Directora)The study of causes and effects of parameters affecting the electrogeneration of mixed oxidants (MOS) in an aqueduct is presented. Variables such as inlet water quality, brine concentration, brine pump voltage and current at constant cell temperature and voltage were the object of intervention. By homogenizing and standardizing the minimum brine saturation concentration that feeds the process to 31.7% through monitoring of correlating variables such as density and refractometry, MOS production was increased to concentrations higher than 4800 mg/L with low variation percentages of 2.7%, reducing salt consumption costs by more than 19 million COP per year and contributing to the operational organizational culture of the process. The automation of the electrogeneration and storage of MOS allows for suitable dosing of chlorination in the potabilization of water, guaranteeing IRCA risk scores of 0%.Item Perfilamiento químico y análisis multivariado de muestras de heroína incautadas en la ciudad de Cúcuta(Universidad Santiago de Cali, 2022-11-25) Ardila Antolines, Jhon Alexander; Osorio Grisales, Jaiver (Director); Ríos Acevedo, Jhon Jairo (Director)Chemical profiling was carried out on ninety-one heroin samples seized at various points in the city of Cúcuta (Colombia), in the period between January 2018 and July 2021. Using gas chromatography with a mass selective detector (GC-MS), it was possible to identify morphine, acetylcodeine, 6- monoacetylmorphine (6-MAM) and papaverine as residual alkaloids. The adulterants present were also determined, identifying phenacetin, cocaine, diltiazem and caffeine, the latter present in 93% of the heroin samples. On the other hand, the quantification shows a trend towards heroin samples with purity between 31% and 50%, respectively. Infrared spectroscopy was used to identify the chemical form and determine other components (diluents) present in the samples. 93% of the samples correspond to heroin hydrochloride and in 9% of the sample’s lactose was identified as a diluent. After profiling, the data of each compound was processed to be analyzed by principal component analysis (PCA) using SPSS software in order to determine if the analyzed samples shared production and traffic sources in common. The PCA grouped the samples related to the alkaloids present, in four different groups of production. With regard to adulterants, three possible different distribution groups are deduced from the PCA.Item Síntesis y caracterización de alquilglucosido a partir de sacha inchi y glucosa asistido por microondas(Universidad Santiago de Cali, 2022-12-02) Carvajal Ruiz, Uberney; Grisales Díaz, Víctor Hugo (Director); Caicedo Cano, Carolina (Directora)A study on the production of an alkylglucoside type non-ionic surfactant is presented using microwaves at a power of 200 W with times of 10, 20 and 30 min and a temperature of 70 °C, the raw materials used for this reaction were sacha oil inchi and glucose, paratoluenesulfonic acid was used as catalyst. The characterizations of the respective products were carried out with fourier transform infrared spectroscopy (FTIR) and residual glucose quantification by means of the colorimetric method of spectrometry by reaction with Antrona. Positive results were obtained from the reaction, resulting in an amount of product equivalent to 24% by weight obtained.Item Optimización económica de un esquema para la recuperación IBE usando un sistema de destilación azeotrópica-extractiva con biodiesel como extractante(Universidad Santiago de Cali, 2023-08-25) Dauquí Gutiérrez, Maryory; Grisales Díaz, Víctor Hugo (Director); Caicedo Cano, Carolina (Directora)Biobutanol is an alternative to fossil-based fuels, it has environmental benefits and it has better properties than ethanol. Biobutanol is produced by ABE (acetone-butanol-ethanol) or IBE (isopropanol-butanol-ethanol) fermentation. Acetone has caused corrosion on engine parts. Therefore, IBE fermentation is preferable for use as fuel. However, purifying IBE implies high energy consumption. This study includes biodiesel as an additional separating agent in azeotropic-extractive distillation to purify IBE. This scheme does not need extractant regeneration by producing biodiesel-IBE blends directly. Eight biodiesel types are evaluated, including vegetable oils, used cooking oil, and microalgae. The effect of biodiesel type and proportion on process costs and energy requirements are investigated using Aspen Plus and MATLAB®. Machine learning methods are applied to develop optimization surrogate models and identify the most significant operating variables. The optimization minimizes total recovery cost, energy intensity and water loss intensity. The results show that the energy requirements with this scheme are reduced up to 1.3 MJ/kg with energy integration.Item Obtención de ferritas deficientes en cobre mediante combustión asistida con glicerina y su aplicación como material de electrodo(Universidad Santiago de Cali, 2023-11-01) Alfonso González, José Guillermo; Morales Morales, Jimmy Alexander (Director); Dector Espinoza, Andrés (Director)Copper-deficient cobalt ferrite nanoparticles were synthesized using a simple combustion method. Various polyalcohol trials were conducted, demonstrating the effectiveness of glycerol as a cosolvent in facilitating the preparation of electrode-modifying nanomaterials. An eight-hour resting period before calcination resulted in a reduction in the secondary phase of hematite. This synthesized material was employed as an electrode material for acetaminophen detection under acidic conditions (pH 2.5). The findings revealed a limit of detection (LOD) of 99.4 nM, a limit of quantification (LOQ) of 331 nM, and a relative standard deviation (RSD) of 3.31%. The superior electrocatalytic activity of the electrode modified with copper-deficient cobalt ferrite (Co0.87Cu0.13Fe2O4/GCE) was strongly correlated with its charge transfer resistance (Rct), as determined using electrochemical impedance spectroscopy (EIS), which defined its electron transfer capability. Importantly, the LOD obtained for Co0.87Cu0.13Fe2O4/GCE in this study (99.4 nM) is lower than that of other electrodes examined. These results indicate the potential for acetaminophen determination in human urine samples using this modified electrode.Item Efectividad de un programa de educación en neurociencia respecto a tratamiento convencional sobre dolor, calidad de vida y capacidad funcional en adultos con dolor oncológico. Ensayo clínico controlado aleatorizado(Universidad Santiago de Cali, 2024) Ordoñez Mora, Leidy Tatiana; Rosero Rosero, Ilem Dayana (Directora); Guil Bozal, Rocío (Directora)One of the symptoms related to cancer, which is often difficult to control, is pain. The prevalence of this symptomatology ranges between 20 and 60%. Regarding intervention options, they range from pharmacological modulation to the use of physical means (cold, electrotherapy), as well as the practice of physical exercise as a modulation mechanism. Previous research has established recommendations for the inclusion of educational interventions in palliative care. In this sense, pain neuroscience education (PNE) is a pain modulation strategy that has gained strength in the last decade. However, research is needed to examine its effectiveness in modulating cancer pain. Therefore, we sought to analyze the effectiveness of a neuroscience education program compared to conventional treatment on pain, quality of life, and functional capacity in adults with cancer pain. A randomized controlled clinical trial was carried out with two groups: one corresponding to PNE, where participants carried out an intervention of nine sessions of 30 minutes each, added to conventional management; the second group only received conventional management as estimated by the treating physician. Sixty-six adults with the presence of cancer pain were included. Based on the initial evaluation, a randomization process was carried out, assigning 33 participants to each group. There was an external evaluator with the objective of generating blindness. The result was that an education program in pain neuroscience compared to conventional treatment can be effective for adults with cancer pain, generating statistically significant changes in pain intensity, pain impact, central sensitization, and biopsychosocial changes such as depression, kinesiophobia, catastrophism, and quality of life. Changes were found in the physical function variables at the level of aerobic capacity. Future interventions should continue with a personalized protocol that allows for patient feedback and incorporates educational processes within palliative care units.Item Simulación de un reactor UASB en una planta de aguas residuales de una empresa embotelladora de bebidas no alcohólicas(Universidad Santiago de Cali, 2024-05-06) Salcedo García, Dayana Del Carmen; Tusso Pinzón, Ricardo Andrés (Director); Castro Narváez, Sandra Patricia (Directora)In this study, an Anaerobic Upflow and Sludge Blanket (UASB) reactor was simulated in Aspen Plus® software under real operating conditions to assess the contaminant load reduction of industrial effluent from a non-alcoholic beverage manufacturing facility. The influent stream entering the reactor was characterized. The results obtained in the initial phase demonstrate compliance with the maximum permissible limits established in the colombian Resolution No. 0631 of March 17, 2015, when compared to the aforementioned standard, with the exception of BOD5 and COD parameters, which exhibited concentrations exceeding 200 mg/L and 400 mg O2/L, respectively. Based on these findings, the reactor was simulated in Aspen Plus® software, achieving a reduction of approximately 79.8% in BOD5 and COD concentrations. Finally, the proposed model was validated against the physicochemical results of the effluent at the reactor outlet, yielding a percentage difference compared to the experimental results of 4.78% for BOD5 and 4.97% for COD. The results of the validation allow the reactor conditions to be reoriented in the non-alcoholic beverage company, positively impacting its processes. Likewise, it will contribute subsequently to the reduction of the organic load on the environment.Item Síndrome post covid-19, implicaciones funcionales y factores relacionados(Universidad Santiago de Cali, 2024-08-23) Daza Arana, Jorge Enrique; Varela Miranda, Rubén Eduardo (Director)COVID-19 is a viral infection that has generated a high burden of morbidity and mortality during the pandemic worldwide, becoming a disabling disease in the population that persists with symptoms after 12 weeks of SARS-CoV infection. 2 and that no alternative diagnosis is attributed. The functional implications of Post COVID-19 Syndrome include the domains of functional impairment, fatigue, quality of life, mental and/or cognitive function problems, and low exercise capacity. Considering that there are only three studies in the country in relation to this syndrome, it was necessary to investigate the municipality of Palmira because it is one of the territories with the highest number of cases in the department of Valle del Cauca and one of those that has greater lethality. A descriptive observational epidemiological study with an analytical component was carried out that allowed us to describe and know the frequency of persistent symptoms, the functional implications and the burden of the affected systems, in relation to the sociodemographic and clinical characteristics. It was found that the population was mainly female, middle and low socioeconomic stratum, had a single event of COVID-19, more than 5 symptoms in the acute stage and received outpatient management. The majority presented a complete vaccination schedule against COVID-19, but only 26.9% had vaccination prior to infection. It was evident that cognitive symptoms represented 88.5% of the persistent symptoms, followed by general (84.6%), musculoskeletal (82.7%) and neurological symptoms (75.8%). In functional status, 70% present minimal to severe limitations. Chronic fatigue had a prevalence of 36.5% (38/104). Regarding quality of life, it was observed that half (50.0%) of the population reports a mild to moderate level of pain or discomfort and around a third (34.6%) a level of anxiety and depression. Cognitive mental function was found with 55.8% at a reduced level. The most affected areas were memory with 88.5%, followed by the visuospatial/executive area with 71.2% and attention 61.5%. It was evidenced that a single episode of acute COVID-19, without critical illness, can develop Post-COVID-19 Syndrome and subsequent vaccination does not seem to be a protective factor. After evaluating the results obtained in this population, the implementation of prevention and management strategies is recommended that facilitate comprehensive rehabilitation in a timely manner with the aim of reducing functional implications.Item Sistema de instrumentación y control de estimulación auditivo y visual con tecnología AIoT para regular el comportamiento(Universidad Santiago de Cali, 2024-09-30) Álvarez García, Gonzalo Alberto; Asorey Cacheda, Rafael (Director); Zúñiga Cañón, Claudia Liliana (Directora)The instrumentation and control systems have allowed the analysis of various systems that touch all aspects of science, developing an evolutionary connection with the needs of human beings and their context, the revolution in the field of biology, industry are just some examples of these scopes. In addition, technologies based on IoT (Internet of Things) systems have interconnected the different devices of our lives, from the simplest thing like turning on or off a light bulb, to being able to control the temperature and humidity of our living spaces. Nowadays, the new reality has posed a new restart to social situations, environments, meeting spaces have suffered due to the situation of the COVID - 19 pandemic, these spaces have not had significant transformations, although our personal spaces, some of them mediated by technology, have been transformed, the conditions in spaces of social interaction have not had an adequate evolution to the technological elements they have. This difference between personal and social spaces has generated a need in which environments and environments must become agents with the capacity to interact with people and to allow both participants and administrators of the spaces a possibility to regulate people’s attitudes and evoke activating or relaxing behaviors. The objective of the work proposed here is to design and build an instrumentation and control system recording the environmental conditions of the environment and generate an auditory and visual stimulus, as a regulatory agent of the environment, with elements of the IoT with robust and accessible technology for the integration of systems for monitoring and control online and also its autonomous operation.Item Evaluación de la acción de residuos agrícolas de papa como materiales carbonosos modificados para la eliminación de contaminantes orgánicos persistentes aguas del río Pasto(Universidad Santiago de Cali, 2024-10-11) Rodríguez Pantoja, Vanessa Estefanía; Ávila Torres, Yenny Patricia (Directora); Flores López, Edwin (Director)With population growth, the consumption of drinking water and the generation of domestic wastewater (DWW) increase. In cities like San Juan de Pasto - Nariño, the lack of wastewater treatment plants (WWTP) has led to direct discharges into water bodies, affecting the health and quality of water sources. These waters contain high levels of organic matter, which promotes the spread of various diseases and negative impacts on public health. For this reason, advanced oxidation processes (AOPs) have emerged as promising technologies for treating organic pollutants in water, based on the generation of reactive oxygen species (ROS). The use of peroxymonosulfate (PMS) enables the generation of the sulfate radical anion SO4●- and the hydroxyl radical ●OH through the cleavage of the peroxo bond. This oxidizing agent offers advantages such as high oxidative potential and low cost. It has been shown to be effective in treating organic pollutants over a wide pH range and has low toxicity. Carbonaceous matrices derived from agricultural residues can be used to activate it. The biochar produced presents functional groups available on the surface, which promote the formation of oxidizing species or enhance adsorption processes. These materials, seen as carbocatalysts in the presence of PMS, are relatively inexpensive, abundant, and can be easily reused. During the development of this research, carbonaceous materials from potato peels (a Nariño biomass) were synthesized, characterized, and functionalized for application in an adsorption and organic matter removal process in a wastewater sample as an alternative to improving its quality. Potato peel carbonization and activation with MnCO3 were carried out to enhance the adsorption and carbocatalysis process. Good results were obtained with concentrations of 0.1 g/L of activated carbon at an initial pH of 5.8. It was determined that the degradation pathway of acetaminophen occurs mainly through singlet oxygen andsuperoxide anion radical, as well as electron transfer on the surface of the manganese-impregnated carbonaceous material, with 100% degradation of the target molecule.Item Análisis del efecto de tres programas de ejercicio en la salud percibida y el afrontamiento Adaptativo de Roy, en adultos mayores. Comuna 11 Cali-Valle del cauca(Universidad Santiago de Cali, 2025) Gaviria Chavarro, Javier; Zambrano Bermeo, Rosa Nury (Director)In recent years, Latin American countries have experienced a rapid process of demographic and epidemiological change due to population aging. This phenomenon has led to an increased prevalence of chronic diseases and age?related muscle mass loss, contributing to frailty, reduced mobility, and a decline in both physical and mental health among older adults. Various studies have suggested that physical activity is an effective strategy for improving quality of life and coping with the changes associated with aging. Objective: To analyze the effect of three exercise programs (coordinative, aerobic, and multimodal) on perceived health, well-being, and Roy’s adaptive coping in older adults from Comuna 11 in Cali, Valle del Cauca. Methodology: A quantitative study was conducted using a quasi-experimental design with a longitudinal and comparative approach. The sample consisted of 450 older adults, selected by convenience sampling and distributed into three intervention groups. Various measurement instruments were applied before and after the intervention, including the SF-12 questionnaire to assess perceived health, the Roy Adaptation Coping Scale (EsCAPS) to measure the adaptation process, the WHO-5 Well-Being Index, and the Senior Fitness Test to evaluate functional physical capacity. Participants engaged in the exercise programs for 12 weeks, with one-hour sessions three times per week. Statistical models, including mean comparison and multivariate analysis, were employed to determine the effects of the interventions. Results: The findings revealed significant improvements in perceived health, well?being, and adaptive coping across all intervention groups. The multimodal program yielded the greatest benefits in physical function, whereas the aerobic program had a more pronounced impact on emotional well-being. A significant reduction in low coping levels and an increase in moderate and high coping levels were observed. Additionally, differences in the effects were identified based on participants' age and initial condition, highlighting a greater impact among those with lower initial physical fitness. Conclusion: This study provides evidence on the effectiveness of exercise programs in enhancing the overall health of older adults. The results support the implementation of exercise-based intervention strategies to promote well-being and adaptation to aging in this population.Item Sistema de medición cuantitativa para determinar el control postural en estudiantes y profesores durante el uso excesivo del Smartphone y su correlación con la Sintomatología musculoesquelética(Universidad Santiago de Cali, 2025) Giraldo Jiménez, Claudia Fernanda; Bermeo Varon, Leonardo Antonio (Director); Felix Rodacki, André Luiz (Director)Background: The use of smartphones can negatively impact the musculoskeletal system due to the constant flexion of the neck and upper limbs. Previous studies have addressed this phenomenon with subjective measurement instruments from various approaches. The Mechanical Movement Dysfunction Model stands out as a possible explanation, and the use of objective measurement systems to identify characteristics of postural control and prevent painful symptoms is a challenge in the health sector. In this sense, the objective of this research is to determine the characteristics of the angles of movement and myoelectric signals involved in the excessive use of smartphones, based on postural changes and muscle fatigue in the neck and upper limbs, and their correlation with the perception of musculoskeletal symptomatology. Methodology: A quantitative study of cross-sectional descriptive design with correlational analysis was carried out, using stratified and convenience sampling, on 50 adults divided into two groups (group 1: students and group 2: professors) from a private university who underwent quantitative measurements by means of IMU and EMGs during smartphone use. Results: There were significant differences in the angles of movement in the head and extremities from the 5 - 10 minute segment, with respect to the characteristics of the myoelectric signals, there were significant differences in the MAV, RMS, AR, MDF, MNF and TTP, as well as in the 5 - 10 minute segment. The most significant characteristics are those of frequency which are reduced, while those of amplitude and power increase. This behavior indicates muscle fatigue. Discussion and Conclusions: The results indicate that musculoskeletal symptomatology and muscle fatigue are present, approximately after 8 minutes of using a Smartphone, which suggests that postural control should be performed, avoiding excessive use of smartphones.Item Diseño de un sistema integral para el manejo del CO2 en la industria cervecera artesanal(Universidad Santiago de Cali, 2025-10-15) Parra Lara, Luis Alejandro; Tusso Pinzón, Ricardo Andrés (Director); Rivadeneira Bolaños, Fabio Eliveny (Director)This research focused on the design, simulation, and optimization of a system for the recovery and storage of carbon dioxide (CO₂) generated during fermentation in microbreweries, with the purpose of reusing it in the carbonation process. Using Aspen Plus software, a system based on chemical absorption with methyldiethanolamine (MDEA) was modeled, achieving a capture efficiency of 99.2% and a purity of 99.9% in the recovered CO₂. Optimal operating conditions including temperature, pressure, and flow rate were evaluated, and key stages such as absorption, solvent regeneration, impurity separation, and flow control were analyzed. The study allowed for a comparison between the volume of CO₂ captured and the actual carbonation needs per production batch, demonstrating the technical feasibility of the system to significantly reduce reliance on external sources. Additionally, international quality standards for food-grade use were identified. The results represent a valuable contribution toward sustainability in the brewing industry, enabling more efficient use of fermentation byproducts and a potential reduction in carbon footprint. This work lays the foundation for future pilot-scale implementations and opens new possibilities for integrating circular economy technologies in small and medium-sized breweries.Item Relación del flujo sanguíneo y la temperatura en función del tiempo con la hiperemia reactiva como indicador temprano de lesiones por presión(Universidad Santiago de Cali, 2025-11-14) Jiménez Cerquera, Catalina ; Zambrano Bermeo, Rosa Nury (Directora); Manrique Julio, Jorge Eliecer (Director)To analyze the time course of skin blood flow and temperature, using reactive hyperemia as an early indicator of pressure injuries in older adults. Methods. We conducted a prospective observational cohort study (n = 55). Descriptive statistics and normality tests were applied; bivariate analyses explored the association and/or significance of other variables with the occurrence of a hyperemic response. The hyperemic response (BF_max) was modeled using discrete-time survival with a complementary log–log (cloglog) link and a log offset. Additionally, a robust logistic/GEE model was fitted including optical–structural determinants (Red/IR ratio, thickness). We constructed a Cutaneous Microvascular Response Index, composed of responsiveness (how fast and how much flow increases) and recovery capacity (ability to return to baseline). Model performance (AUC, Brier score) and associations (OR/HR with 95% CI) were assessed. Results. We characterized the temporal behavior of blood flow and temperature at the evaluated site up to the onset of the hyperemic response, identified its latency and conditions of occurrence, and proposed a model that not only represents the data dynamics but also shows potential utility to stratify cutaneous microvascular risk and complement clinical scales such as Braden.Item Evaluación de sistemas oxidativos basados en luz UV sobre la inactivación y susceptibilidad de hongos patógenos humanos aislados de plantas de tratamiento de la ciudad de Cali(Universidad Santiago de Cali, 2025-11-28) Caicedo Bejarano, Luz Dary; Correa Bermúdez, Adriana María (Directora); Serna Galvis, Efraím Adolfo (Director)Aquatic systems, such as wastewater and drinking water, serve as reservoirs for pathogenic fungi, including species resistant to antifungals like azoles and echinocandins. In Cali, Colombia, wastewater and drinking water were evaluated, revealing 14 genera and 21 species of yeasts, with Candida present in all sampling sites. A 32.7% resistance to fluconazole was observed, influenced by physicochemical parameters and the presence of heavy metals, including Cr, Cd, Fe, Zn, and Pb. Tests with C. albicans showed that UVC/peroxide processes follow first-order kinetics, with UVC/H2O2 proving most effective, reducing susceptibility to fluconazole from 64 to 8 μg/mL. Yeasts exhibited low reactivation in darkness, indicating that using •OH and SO4•- radicals is a cost-efficient method for treating resistant yeasts. It is advisable to investigate the spread of resistant communities in the Cauca River and to expand these treatments to hospital systems.Item Evaluación de tecnologías emergentes para el tratamiento de aguas residuales industriales en Colombia: Una revisión sistemática(Universidad Santiago de Cali, 2025-12-05) Osorio Campo, David Alberto; Ocampo Chagüendo, Dennis Mauricio (Director)The management of industrial wastewater in Colombia currently remains one of the greatest challenges, both in environmental and technological terms for the productive sector. Although Resolution 0631 of 2015 establishes clear parameters for discharges, in practice, many companies—especially small and medium-sized enterprises— fail to meet these standards. Conventional technologies, although widely used, are insufficient when facing pollutants such as heavy metals, synthetic dyes, or hard-to-degrade organic compounds. Emerging technologies appear as a real alternative to improve treatment efficiency. This work focused on analyzing and comparing the emerging technologies with the greatest potential for application in Colombia for the treatment of industrial wastewater, taking into account their technical performance, operational feasibility, implementation costs, and level of compliance with current regulations. The methodology used was based on a literature review of studies published between 2015 and 2024, focusing on four technologies: electrocoagulation, advanced oxidation processes (AOPs), membrane systems, and centrifugation. The findings highlight that these technologies offer several important advantages over traditional methods, both in terms of contaminant removal efficiency and process automation, as well as in the reduction of secondary waste. Electrocoagulation and centrifugation show a high level of maturity (TRL ≥ 8). On the other hand, membranes and AOPs require greater technical and financial resources but can produce effluents of excellent quality. The study concludes with a series of proposals to facilitate their progressive adoption, such as financing schemes, technical training, and strategies tailored to the type of industry.Item Development of Business Architecture for the manufacture of swarms of unmanned aerial vehicles in the context of Industry 4.0(Universidad Santiago de Cali, 2025-12-11) Díaz Velásquez, María Fernanda; Tavera Romero, Carlos Andrés (Director)This research project develops a Business Architecture pattern with its artefacts for designing the organisational structure of a factory dedicated to the production of swarms of unmanned aerial vehicles (UAVs) in the context of Industry 4.0. To formalise and validate the pattern, the Conceive, Design, Implement and Operate (CDIO) methodology is adopted. Within this framework, architectural solutions are proposed that integrate a co-intelligence artefact (human-machine cooperation) into decision-making processes, with the aim of boosting productivity, streamlining operations and transforming business models. The resulting pattern articulates intelligent and interconnected systems and technologies specific to Industry 4.0, and is scalable and adaptable.