Facultad de Ciencias Básicas
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Browsing Facultad de Ciencias Básicas by Author "Acevedo Restrepo, Isabel (Directora)"
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Item Avances en la detección de ketamina: Revisión sistemática(Universidad Santiago de Cali, 2025) Hernández Gaviria, María Inés; Ciro Monsalve, Yhors Alexander (Director); Acevedo Restrepo, Isabel (Directora)Ketamine is a substance used both medically and recreationally, and its detection poses a challenge in clinical and forensic contexts. This systematic review aims to evaluate the approaches used to identify ketamine and its metabolites in biological matrices and beverages. A bibliographic search was carried out following the PRISMA Declaration in databases such as PubMed, Scopus, and ScienceDirect, among others, resulting in 15 selectedstudies published between 2010 and 2025. The methods described include conventional chromatographic techniques (LC-MS/MS, GC-MS), as well as electrochemical, optical, and paper-based biosensors. Sensors based on molecular imprinting, aptamers, and nanostructured materials stood out for their portability, low cost, and analysis times of less than 10 minutes. Alternative matrices (saliva, hair, and adulterated beverages) demonstrated significant advances in sensitivity, specificity, and in situ applicability. However, challenges remain in validation and standardization processes. It is concluded that methodological diversity enables broader and more timely ketamine detection, with implications for public health, justice, and the prevention of drug-facilitated crimes. Keywords: Biological matrices; biosensorsItem Metodologías para la detección de cocaína en sangre: una revisión sistemática(Universidad Santiago de Cali, 2025) Ortega Losada, María Fernanda; Ciro Monsalve, Yhors Alexander (Director); Acevedo Restrepo, Isabel (Directora)The detection of cocaine and its metabolites in blood is of great clinical and forensic relevance due to the toxicological, legal, and public health implications associated with its use. This systematic review analyzes the most commonly used methodologies for such detection, highlighting liquid chromatography-tandem mass spectrometry (LC-MS/MS), immunoassays, and emerging techniques such as nanoparticle-based potentiometric sensors. A search was conducted in recognized scientific databases, applying inclusion and exclusion criteria defined under the PRISMA 2020 declaration. From the selected articles, information was extracted on the sensitivity, specificity, advantages, limitations, and applicability of each method. Although LC-MS/MS remains the standard due to its high accuracy, alternative methods useful in specific contexts were identified.