Química Farmacéutica
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Browsing Química Farmacéutica by Author "Canas Rodríguez, Sebastian"
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Item Cannabis medicinal en el tratamiento alternativo del insomnio crónico en pacientes polimedicados: Una revisión sistemática(Universidad Santiago de Cali, 2025) Canas Rodríguez, Sebastian; Rojas Barreto, Julián Alonso (Director)Chronic insomnia represents a significant public health problem which affects the quality of life of a considerable proportion of the population. This condition is exacerbated in patients taking multiple medications, who frequently seek alternatives to conventional treatments to minimize adverse effects. In this context, medicinal cannabis has emerged as a promising therapeutic option due to its potential to improve sleep quality. A systematic review was developed following PRISMA guidelines, which included an exhaustive search in electronic databases. The characteristics of the studies, population, interventions and results were analyzed, evaluating the methodological quality using specific tools for clinical trials and observational studies. The main compounds in cannabis, THC and CBD, were found to interact with the endocannabinoid system to regulate sleep patterns. THC showed sedative effects, while CBD showed benefits in treating insomnia by reducing anxiety and stress, contributing factors to sleep disorders. CBD has shown particular promise for its anxiolytic properties and ability to improve sleep quality without the psychoactive effects characteristic of THC. It was concluded that more rigorous clinical trials are needed to establish specific recommendations on the use of medicinal cannabis in the treatment of chronic insomnia, emphasizing the importance of a personalized approach.