Química Farmacéutica
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Browsing Química Farmacéutica by Author "Campaña Forero, Joan Sebastián"
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Item Biopelículas con extracto de Psidium guineense: innovación verde para terapias antiinflamatorias(Universidad Santiago de Cali, 2025-12-11) Quiñones Perea, Sara; Campaña Forero, Joan Sebastián; Ciro Monsalve, Yhors Alexander (Director); Illicachi Romero, Luis Alberto (Director)The main objective of the research project was the elaboration, characterization and evaluation of polymeric films based on sodium alginate, glycerol and ethanolic extract of P. guineense with potential anti-inflammatory activity, selected for its high content of phenolic compounds, flavonoids and tannins, recognized for their antioxidant and anti-inflammatory capacity, it was chosen to be formulated in biofilm because this form allows direct topical application, protection of the extract and controlled release. On the other hand, sodium alginate was chosen as a film-forming polymer because it is biodegradable, biocompatible, non-toxic and capable of forming hydrable matrices that retain and release active ingredients in a sustained manner, The extract was obtained by means of ultrasound and characterized through phytochemical test and thin layer chromatography, confirming the presence of phenolic compounds and flavonoids, quantification of these phenolic compounds by the method of Folin-Ciocalteu. The anti-inflammatory activity was evaluated from the method of inhibition of protein denaturation, obtaining 44% as a result of inhibition for the free extract and 61% for the biofilm, these results were comparable to diclofenac sodium (62%). The findings show that the polymeric matrix largely favored the sustained release of the extract, preserving its bioactivity and evidencing its potential as a topical, biodegradable and controlled-release anti-inflammatory system.