Química Farmacéutica
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Browsing Química Farmacéutica by Author "Bravo Rios, Esteban"
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Item Aplicación de técnicas cromatográficas y espectrometría de masas para la identificación y cuantificación de catinonas sintéticas en muestras incautadas: Una revisión sistemática(Universidad Santiago de Cali, 2026-02-09) Bravo Rios, Esteban; Ocampo Chaguendo, Dennis Mauricio (Director)Synthetic cathinones or "bath salts", are powerful derivatives of the natural cathinone of the khat bush. They emerged as legal alternatives to amphetamines and MDMA, taking advantage of changes in their chemical structure to circumvent international regulations. Due to their constant molecular evolution and the emergence of positional isomers (such as 3-CMC and 4-CMC), their detection represents a critical challenge for forensic toxicology. The methodology of this review followed the PRISMA protocol, analyzing 16 studies selected from scientific databases: Nature, Oxford, PubMed, Scielo, ScienceDirect, Springer nature, Taylor & Francis and performing a grey search in the Google Schoolar database under the inclusion and exclusion criteria and in the time interval from 2019 to 2025. Gas chromatography (GC) and liquid chromatography (HPLC), coupled with mass spectrometry (MS), are the reference techniques due to their high sensitivity and molecular identification capacity. Although these tools allow complex mixtures and impregnated samples to be analysed, they face limitations such as the high cost of equipment, the need for specialized personnel and the difficulty in distinguishing isomers with identical fragmentations.