Química Farmacéutica
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Browsing Química Farmacéutica by Author "Botache Pulgarin, Valeria"
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Item Formas farmacéuticas, dosis, mecanismos de acción y aplicaciones clínicas de los probióticos en humanos: revisión sistemática(Universidad Santiago de Cali, 2025-12-09) Botache Pulgarin, Valeria; González Vargas, Iván Andrés (Director); Corredor Sáenz, Viviana Catalina (Directora)The use of probiotics in human health has gained great relevance in recent years due to their potential to modulate the gut microbiota and act as therapeutic adjuvants in various diseases. However, there are still important challenges related to the lack of standardization in the doses administered, the selection of specific strains, the dosage forms used and the duration of treatments, which hinders comparison between studies and the consolidation of clinical guidelines, limiting their clinical application and acceptance by health professionals. where, in addition, the lack of consensus and heterogeneity in international regulations on the use of probiotics prevent effective integration into health systems. In this context, a review of the literature published between 2020 and 2025 was carried out, with the purpose of consolidate scientific evidence around four central categories: doses, dosage forms, mechanisms of action, and treatments in specific diseases. The search included controlled clinical trials, pilot studies and experimental work in humans, guaranteeing the inclusion of primary sources of greater scientific rigor, with which this work contributes to strengthening the evidence base in a field of growing interest for pharmaceutical and clinical research.