Química Farmacéutica
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Browsing Química Farmacéutica by Author "Boada Tascón, Valentina"
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Item Contaminantes químicos en materias primas falsificadas y medicamentos asociados a intoxicación: Una revisión(Universidad Santiago de Cali, 2025-12-13) Boada Tascón, Valentina; Ciro Monsalve, Yhors Alexander (Director)Medicines that do not meet quality standards pose risks to treatment effectiveness, negatively impacting the health of those who use them. The objective of this article is to identify the chemical contaminants present in substandard and counterfeit medicines, whose presence contributes to cases of poisoning. The methodology used was a systematic review of studies published between 2020 and 2025 and indexed in scientific databases, following the PRISMA methodology. Academic databases (ScienceDirect, PubMed, Scopus, Springer, Redalyc, Scielo, Google Scholar, among others) were consulted using DeCS and MeSH descriptors in Spanish and English, combined with Boolean operators. The results showed that drug groups such as antibiotics, antimalarials, antituberculosis drugs, antihypertensives, antidiabetics, antivirals, oncological drugs, contraceptives, and pediatric medications have a higher prevalence of substandard and counterfeit products. It was observed that, after the COVID-19 pandemic, counterfeiting increased due to higher demand and less regulatory control. Various analytical techniques are used for control, allowing the identification of organic impurities, degradation, trace-level mutagenic impurities, heavy metals, and/or biological products, as well as structural characterization. The review of the different studies concludes that the circulation of substandard and counterfeit medicines occurs in various countries, being more prevalent in developing countries due to the presence of illicit economies, lack of controls, and inadequate regulation, which poses risks to consumers, reduces treatment efficacy, and impacts public health.