Química Farmacéutica

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Obtención de liposomas cargados con el extracto hidroalcohólico Physalis Peruviana L. para su incorporación en un parche transdérmico
(Universidad Santiago de Cali, 2025-12-12) Benítez Daza, Ana María; Zabala Mosquera, Karen Dahianna; Ciro Monsalve, Yhors Alexander (Director); Illicachi Romero, Luis Alberto (Director)
Physalis peruviana L. (cape gooseberry) is an herbaceous plant of the Solanaceae family with recognized antiinflammatory properties attributed to secondary metabolites such as withanolides, steroidal lactones, and flavonoids. This study aimed to evaluate the presence of these metabolites through qualitative and quantitative tests, obtaining positive results in the phytochemical assays of Shinoda, total phenols, and Liebermann–Burchard. Quantification by UV–Vis spectrophotometry revealed a total content of 7,23 mg GAE/g of polyphenols and 1,22 mg RE/g of flavonoids. Subsequently, liposomes were formulated with the extract, achieving encapsulation efficiencies of 74,71% for polyphenols and 80,68% for flavonoids. Finally, the formulation was optimized with 2% carboxymethylcellulose for the development of a transdermal patch containing liposomal load, with an average weight of 0,923 ± 0,094 g and a thickness of 0,967 ± 0,059 mm.