When Serendipity Knocks on the Door: Synthesis and Physicochemical Characterization of 7-Chloro-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-5-one

dc.contributor.author	Carmona-Vargas, Christian C.
dc.contributor.author	Ellena, Javier
dc.contributor.author	D’Vries, Richard F.
dc.contributor.author	Chaur, Manuel N.
dc.date.accessioned	2019-08-05T21:51:05Z
dc.date.available	2019-08-05T21:51:05Z
dc.date.issued	2019
dc.description.abstract	Herein, we present the serendipitous obtaining of 7-chloro-2,3-dihydro-5H-thiazolo [3,2-a]pyrimidin-5-one in 40% yield by using POCl3 and a thiobarbituric acid derivative. The thiazolopyrimidine derivative was characterized by 1H nuclear magnetic resonance (NMR), UV-Vis, and Fourier transform infrared (FTIR) spectroscopy. Additionally, the structure was conﬁrmed by single crystal X-ray diffraction, where it was found that the compound crystallizes in the P-1 triclinic space group with two conformeric molecules of 7-chloro-2,3-dihydro-5H-thiazolo [3,2-a]pyrimidin-5-one by asymmetric unit. Also, from the structural data was studied the supramolecular interactions using Hirshfeld surface analysis and 2D ﬁngerprint plots.	en_US
dc.identifier.issn	1678-4790
dc.identifier.uri	https://repositorio.usc.edu.co/handle/20.500.12421/471
dc.language.iso	en	en_US
dc.publisher	Journal of the Brazilian Chemical Society	en_US
dc.subject	chlorination	en_US
dc.subject	thiobarbituric acid	en_US
dc.subject	serendipity	en_US
dc.subject	thiazolopyrimidine	en_US
dc.title	When Serendipity Knocks on the Door: Synthesis and Physicochemical Characterization of 7-Chloro-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-5-one	en_US
dc.type	Article	en_US

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