Antibacterial activity and molecular studies of non-symmetric POCOP-Pd(II) pincer complexes derived from 2,4-dihydroxybenzaldehyde (2,4-DHBA)
| dc.contributor.author | Aragón Muriel, Alberto | |
| dc.contributor.author | Aguilar Castillo, Bethsy A. | |
| dc.contributor.author | Rufino Felipe, Ernesto | |
| dc.contributor.author | Valdés, Hugo | |
| dc.contributor.author | González Sebastián, Lucero | |
| dc.contributor.author | Osorio Yáñez, Rebeca Nayely | |
| dc.contributor.author | Liscano, Yamil | |
| dc.contributor.author | Gómez Benítez, Valente | |
| dc.contributor.author | Polo Cerón, Dorian | |
| dc.contributor.author | Morales Morales, David | |
| dc.date.accessioned | 2025-03-31T22:52:10Z | |
| dc.date.available | 2025-03-31T22:52:10Z | |
| dc.date.issued | 2022-11-15 | |
| dc.description.abstract | A series of non-symmetric POCOP-Pd(II) pincer complexes including an aldehyde group in the meta-position of the aromatic pincer-backbone were prepared and characterized. The molecular structure of complex 1-Pd was unambiguously determined by single crystal X-ray diffraction analysis, showing a square-planar geometry around the metal fragment and the presence of the aldehyde functionality at the pincer ligand backbone. The evaluation of the antibacterial activities of complexes 2-Pd and 3-Pd against gram-positive and gram-negative strains was performed. Complex 3-Pd was the most active against S. aureus ATCC 25923 strain with a MIC value of 8 µg∙mL−1. We also determined by molecular docking studies, that pincer complexes 2-Pd and 3-Pd may interact with some key bacterial enzymes such as KPC-2 and PBP2A. | |
| dc.identifier.citation | Aragón-Muriel, A., Aguilar-Castillo, B. A., Rufino-Felipe, E., Valdés, H., González-Sebastián, L., Osorio-Yáñez, R. N., Liscano, Y., Gómez-Benítez, V., Polo-Cerón, D., & Morales-Morales, D. (2022). Antibacterial activity and molecular studies of non-symmetric POCOP-Pd(II) pincer complexes derived from 2,4-dihydroxybenzaldehyde (2,4-DHBA). Polyhedron, 227. https://doi.org/10.1016/j.poly.2022.116115 | |
| dc.identifier.issn | 02775387 | |
| dc.identifier.uri | https://repositorio.usc.edu.co/handle/20.500.12421/6168 | |
| dc.language.iso | en | |
| dc.title | Antibacterial activity and molecular studies of non-symmetric POCOP-Pd(II) pincer complexes derived from 2,4-dihydroxybenzaldehyde (2,4-DHBA) | |
| dc.type | Article |
Files
Original bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- Antibacterial activity and molecular studies of non-symmetric POCOP-Pd(II) pincer complexes derived from 2,4-dihydroxybenzaldehyde (2,4-DHBA).pdf
- Size:
- 5.2 MB
- Format:
- Adobe Portable Document Format
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed upon to submission
- Description: