Development of a novel formulation with hypericin to treat cutaneous leishmaniasis based on photodynamic therapy in in vitro and in vivo studies

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dc.contributor.authorMontoya, Andrés
dc.contributor.authorDaza, Alejandro
dc.contributor.authorMuñoz, Diana
dc.contributor.authorRíos, Karina
dc.contributor.authorTaylor, Viviana
dc.contributor.authorCedeño, David
dc.contributor.authorVélez, Iván D.
dc.contributor.authorEcheverri, Fernando
dc.contributor.authorRobledoa, Sara M.
dc.date.accessioned2019-06-28T22:10:07Z
dc.date.available2019-06-28T22:10:07Z
dc.date.issued2015-09-01
dc.description.abstractAn evaluation of the leishmanicidal activity in vitro and in vivo of hypericin, an expanded-spectrum photosensitizer found in Hypericum perforatum, is presented. Hypericin was evaluated against intracellular amastigotes in vitro of Leishmania (Viannia) panamensis. A topical formulation containing 0.5% hypericin was developed and assayed in vivo in a hamster model of cutaneous leishmaniasis. Results demonstrate that hypericin induces a significant antiamastigote effect in vitro against L. panamensis by decreasing the number of parasites inside infected cells. The topical formulation of 0.5% hypericin allows healing of L. panamensis-induced lesions upon a topical application of 40 mg/day plus visible-light irradiation (5 J/cm 2 , 15 min), twice a week for 3 weeks. Copyright © 2015, American Society for Microbiology. All Rights Reserved.en_US
dc.identifier.issn00664804
dc.identifier.urihttps://repositorio.usc.edu.co/handle/20.500.12421/237
dc.language.isoesen_US
dc.publisherUniversidad Santiago de Calien_US
dc.subjectAnimalsen_US
dc.subjectCell Lineen_US
dc.subjectCricetinaeen_US
dc.subjectHumansen_US
dc.subjectLeishmaniaen_US
dc.subjectLeishmaniasis, Cutaneousen_US
dc.subjectPeryleneen_US
dc.subjectPhotochemotherapyen_US
dc.subjectPhotosensitizing Agentsen_US
dc.subjectU937 Cellsen_US
dc.subjectWound Healingen_US
dc.subjectdrug absorptionen_US
dc.subjectdrug efficacyen_US
dc.subjectcytotoxicityen_US
dc.subjectamphotericin B deoxycholateen_US
dc.subjectepidermal growth factoren_US
dc.subjectglyceraldehyde 3 phosphate dehydrogenaseen_US
dc.titleDevelopment of a novel formulation with hypericin to treat cutaneous leishmaniasis based on photodynamic therapy in in vitro and in vivo studiesen_US
dc.typeArticleen_US

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