When serendipity knocks on the door: Synthesis and Physicochemical Characterization of 7-Chloro-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-5-one

dc.contributor.author	Carmona-Vargas, Christian C.
dc.contributor.author	Ellena, Javier
dc.contributor.author	D’Vries, Richard F.
dc.contributor.author	Chaur, Manuel N.
dc.date.accessioned	2019-11-06T16:24:36Z
dc.date.available	2019-11-06T16:24:36Z
dc.date.issued	2019-03-19
dc.description.abstract	Herein, we present the serendipitous obtaining of 7-chloro-2,3-dihydro-5H-thiazolo [3,2-a]pyrimidin-5-one in 40% yield by using POCl3 and a thiobarbituric acid derivative. The thiazolopyrimidine derivative was characterized by 1H nuclear magnetic resonance (NMR), UV-Vis, and Fourier transform infrared (FTIR) spectroscopy. Additionally, the structure was confirmed by single crystal X-ray diffraction, where it was found that the compound crystallizes in the P-1 triclinic space group with two conformeric molecules of 7-chloro-2,3-dihydro-5H-thiazolo [3,2-a]pyrimidin-5-one by asymmetric unit. Also, from the structural data was studied the supramolecular interactions using Hirshfeld surface analysis and 2D fingerprint plots. © 2019 Sociedade Brasileira de Química	es
dc.identifier.issn	01035053
dc.identifier.uri	https://repositorio.usc.edu.co/handle/20.500.12421/2050
dc.language.iso	en	es
dc.publisher	Sociedade Brasileira de Quimica	es
dc.subject	Chlorination	es
dc.subject	Serendipity	es
dc.subject	Thiazolopyrimidine	es
dc.subject	Thiobarbituric acid	es
dc.title	When serendipity knocks on the door: Synthesis and Physicochemical Characterization of 7-Chloro-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-5-one	es
dc.type	Article	es

Files

Now showing 1 - 1 of 1

Name:: When serendipity knocks on the door Synthesis and Physicochemical Characterization of 7-Chloro-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-5-one.pdf
Size:: 1.98 MB
Format:: Adobe Portable Document Format
Description:

Now showing 1 - 1 of 1