Human papillomavirus in upper digestive tract tumors from three countries
| dc.contributor.author | Castillo, Andrés | |
| dc.contributor.author | Koriyama, Chihaya | |
| dc.contributor.author | Higashi, Michiyo | |
| dc.contributor.author | Anwar, Muhammad Maqsood | |
| dc.contributor.author | Bukhari, Mulazim Hussain | |
| dc.contributor.author | Carrascal, Edwin | |
| dc.contributor.author | Mancilla, Lida I. | |
| dc.contributor.author | Matsumoto, Matsutaka | |
| dc.contributor.author | Sugihara, Kazumasa | |
| dc.contributor.author | Natsugoe, Shoji | |
| dc.contributor.author | Eizuru, Yoshito | |
| dc.contributor.author | Akiba, Suminori | |
| dc.contributor.author | Okumura, Hiroshi | |
| dc.date.accessioned | 2019-07-10T19:44:03Z | |
| dc.date.available | 2019-07-10T19:44:03Z | |
| dc.date.issued | 2011-12-28 | |
| dc.description.abstract | AIM: To clarify human papillomavirus (HPV) involvement in carcinogenesis of the upper digestive tract of virological and pathological analyses. METHODS: The present study examined the presence of HPV in squamous cell carcinomas of the oral cavity (n = 71), and esophagus (n = 166) collected from Japan, Pakistan and Colombia, with different HPV exposure risk and genetic backgrounds. The viral load and physical status of HPV16 and HPV16-E6 variants were examined. Comparison of p53 and p16INK4a expression in HPV-positive and HPV-negative cases was also made. RESULTS: HPV16 was found in 39 (55%) oral carcinomas (OCs) and 24 (14%) esophageal carcinomas (ECs). This site-specific difference in HPV detection between OCs and ECs was statistically significant (P < 0.001). There was a significant difference in the geographical distribution of HPV16-E6 variants. Multiple infections of different HPV types were found in 13 ECs, but multiple infections were not found in OCs. This difference was statistically significant (P = 0.001). The geometric means (95% confidence interval) of HPV16 viral load in OCs and ECs were 0.06 (0.02-0.18) and 0.12 (0.05-0.27) copies per cell, respectively. The expression of p16INK4a proteins was increased by the presence of HPV in ECs (53% and 33% in HPV-positive and -negative ECs, respectively; P = 0.036), and the high-risk type of the HPV genome was not detected in surrounding normal esophageal mucosa of HPV-positive ECs. CONCLUSION: Based on our results, we cannot deny the possibility of HPV16 involvement in the carcinogenesis of the esophagus. © 2011 Baishideng. All rights reserved. | en_US |
| dc.identifier.issn | 10079327 | |
| dc.identifier.uri | https://repositorio.usc.edu.co/handle/20.500.12421/357 | |
| dc.language.iso | en | en_US |
| dc.subject | E6 | en_US |
| dc.subject | Human papillomavirus | en_US |
| dc.subject | p16INK4a | en_US |
| dc.subject | P53 | en_US |
| dc.subject | Physical status | en_US |
| dc.subject | Viral load | en_US |
| dc.subject | Protein p16 | en_US |
| dc.subject | Protein p53 | en_US |
| dc.subject | Digestive system cancer | en_US |
| dc.subject | Esophagus carcinoma | en_US |
| dc.subject | Human tissue | en_US |
| dc.subject | Nonhuman | en_US |
| dc.subject | Carcinoma, Squamous Cell | en_US |
| dc.subject | Aged | en_US |
| dc.subject | Cell Transformation, Neoplastic | en_US |
| dc.subject | Middle Aged | en_US |
| dc.subject | Colombia | en_US |
| dc.subject | Japan | en_US |
| dc.subject | Pakistan | en_US |
| dc.subject | Oncogene Proteins, Viral | en_US |
| dc.title | Human papillomavirus in upper digestive tract tumors from three countries | en_US |
| dc.type | Article | en_US |
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