A facile synthesis of stable β-amino-N-/O-hemiacetals through a catalyst-free three-component Mannich-type reaction
| dc.contributor.author | Abonia, Rodrigo | |
| dc.contributor.author | Castillo, Juan C. | |
| dc.contributor.author | Garay, Alexander | |
| dc.contributor.author | Insuasty, Braulio | |
| dc.contributor.author | Quiroga, Jairo | |
| dc.contributor.author | Nogueras, Manuel | |
| dc.contributor.author | Cobo, Justo | |
| dc.contributor.author | D’Vries, Richard F. | |
| dc.date.accessioned | 2019-08-06T03:13:54Z | |
| dc.date.available | 2019-08-06T03:13:54Z | |
| dc.date.issued | 2017 | |
| dc.description.abstract | A practical, straightforward and one-step procedure for the synthesis of novel and stable β-amino-N-/O-hemiacetals (i.e γ-aminoalcohols) is provided. The title compounds were obtained in good to excellent yields through an uncatalyzed three-component reaction by treatment of secondary amines with polyformaldehyde and electron-rich alkenes in acetonitrile as solvent at ambient temperature. The reactions proceeded with the formation of iminium ions, through a Mannich-type reaction, as the key intermediates for the generation of the target products. Single crystal X-ray analysis of derivative 4l confirmed unequivocally the structure and stability of the obtained compounds. | en_US |
| dc.identifier.issn | 0040-4039 | |
| dc.identifier.uri | https://repositorio.usc.edu.co/handle/20.500.12421/491 | |
| dc.language.iso | en | en_US |
| dc.publisher | Tetrahedron Letters | en_US |
| dc.subject | Multicomponent reactions | en_US |
| dc.subject | Aminoalcohols | en_US |
| dc.subject | Hemiacetals | en_US |
| dc.subject | Green chemistry | en_US |
| dc.subject | Mannich-type reaction | en_US |
| dc.title | A facile synthesis of stable β-amino-N-/O-hemiacetals through a catalyst-free three-component Mannich-type reaction | en_US |
| dc.type | Article | en_US |
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