The phenotypic consequences of genetic divergence between admixed latin american populations: Antioquia and Chocó, Colombia
| dc.contributor.author | Chande, Aroon T. | |
| dc.contributor.author | Rishishwar, Lavanya | |
| dc.contributor.author | Ban, Dongjo | |
| dc.contributor.author | Nagar, Shashwat D. | |
| dc.contributor.author | Conley, Andrew B. | |
| dc.contributor.author | Rowell, Jessica | |
| dc.contributor.author | Valderrama Aguirre, Augusto E. | |
| dc.contributor.author | Medina Rivas, Miguel A. | |
| dc.contributor.author | Jordan, I. King | |
| dc.date.accessioned | 2025-07-28T20:29:54Z | |
| dc.date.available | 2025-07-28T20:29:54Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Genome-wide association studies have uncovered thousands of genetic variants that are associated with a wide variety of human traits. b Knowledge of howtrait-associated variants are distributed within and between populations can provide insight into the genetic basis of a group-specific phenotypic differences, particularly for health-related traits. We analyzed the genetic divergence levels for 1) individual i trait-associated variants and 2) collections of variants that function together to encode polygenic traits, between two neighboring 1 populations in Colombia that have distinct demographic profiles: Antioquia (Mestizo)and Choco (Afro-Colombian). Genetic ancestry 9 analysis showed 62% European, 32% Native American, and 6% African ancestry for Antioquia compared with 76% African, 10% 5 European, and 14% Native American ancestry for Choco, consistent with demography and previous results. Ancestry differences can g confound cross-population comparison of polygenic risk scores (PRS); however, we did not find any systematic bias in PRS distributions 7 for the two populations studied here, and population-specific differences in PRS were, for the most part, small and symmetrically 1 distributed around zero. Both genetic differentiation at individual trait-associated single nucleotide polymorphisms and population- b specific PRS differences between Antioquia and Choco largely reflected anthropometric phenotypic differences that can be readily g observed between the populations along with reported disease prevalence differences. Cases where population-specific differences in $ genetic risk did not align with observed trait (disease) prevalence point to the importance of environmental contributions to phenotypic g variance, for both infectious and complex, common disease. The results reported here are distributed via a web-based platform for 3 searching trait-associated variants and PRS divergence levels at http://map.chocogen.com (last accessed August 12, 2020) | |
| dc.identifier.citation | Chande, A. T., Rishishwar, L., Ban, D., Nagar, S. D., Conley, A. B., Rowell, J., Valderrama-Aguirre, A. E., Medina-Rivas, M. A., & Jordan, I. K. (2021). The phenotypic consequences of genetic divergence between admixed latin american populations: Antioquia and Chocó, Colombia. Genome Biology and Evolution, 12(9), 1516–1527. https://doi.org/10.1093/GBE/EVAA154 | |
| dc.identifier.issn | 17596653 | |
| dc.identifier.uri | https://repositorio.usc.edu.co/handle/20.500.12421/7670 | |
| dc.language.iso | en | |
| dc.subject | Disease | |
| dc.subject | Genetic ancestry | |
| dc.subject | Health | |
| dc.subject | Polygenic | |
| dc.subject | Population genomics | |
| dc.subject | Traits | |
| dc.title | The phenotypic consequences of genetic divergence between admixed latin american populations: Antioquia and Chocó, Colombia | |
| dc.type | Article |