Association of CETP, APOA5, IL6, and PON1 Gene Variants with Dyslipidemia and Cardiovascular Risk in a Population from Cauca Department, Colombia
| dc.contributor.author | Urbano Cano, Astrid Lorena | |
| dc.contributor.author | Álvarez Rosero, Rosa Elvira | |
| dc.contributor.author | Liscano, Yamil | |
| dc.date.accessioned | 2025-07-18T20:06:51Z | |
| dc.date.available | 2025-07-18T20:06:51Z | |
| dc.date.issued | 2025-04-30 | |
| dc.description | Antecedentes: Las enfermedades cardiovasculares siguen siendo la principal causa de muerte en todo el mundo, y la dislipidemia es un factor de riesgo crítico y modificable. Objetivo: Se buscó evaluar la relación entre polimorfismos en CETP (rs3764261), APOA5 (rs662799), IL6 (rs1800796), y PON1 (Q192R) y parámetros lipídicos, y evaluar su contribución a la dislipidemia y al riesgo cardiovascular global en una cohorte urbana del Cauca, Colombia. Métodos: En este estudio observacional transversal, se inscribieron 304 participantes de 40-69 años de edad. Se recogieron datos clínicos, antropométricos y bioquímicos, y se realizó la genotipificación de los cuatro polimorfismos diana. Se utilizaron estadísticas descriptivas para caracterizar la muestra, pruebas no paramétricas para comparar los niveles de lípidos por genotipo y regresión logística multivariable para identificar predictores independientes de dislipidemia. Resultados: Los individuos con dislipidemia presentaban niveles significativamente más altos de colesterol total y VLDL, niveles más bajos de HDL y un índice de Castelli II elevado en comparación con el grupo sin dislipidemia. Aunque las frecuencias del genotipo CETP diferían entre los grupos, sólo la variante APOA5 rs662799 se asoció significativamente con niveles elevados de VLDL, lo que sugiere su posible papel como biomarcador genético del riesgo cardiovascular. | |
| dc.description.abstract | Background: Cardiovascular disease remains the leading cause of death worldwide, and dyslipidemia is a critical, modifiable risk factor. Aim: We sought to evaluate the relationship between polymorphisms in CETP (rs3764261), APOA5 (rs662799), IL6 (rs1800796), and PON1 (Q192R) and lipid parameters, and to assess their contribution to dyslipidemia and overall cardiovascular risk in an urban cohort from Cauca, Colombia. Methods: In this cross-sectional observational study, 304 participants aged 40–69 years were enrolled. Clinical, anthropometric, and biochemical data were collected, and genotyping was performed for the four target polymorphisms. We used descriptive statistics to characterize the sample, non-parametric tests to compare lipid levels by genotype, and multivariable logistic regression to identify independent predictors of dyslipidemia. Results: Individuals with dyslipidemia exhibited significantly higher total cholesterol and VLDL levels, lower HDL levels, and an elevated Castelli II index compared with the non-dyslipidemia group. Although CETP genotype frequencies differed between groups, only the APOA5 rs662799 variant was significantly associated with increased VLDL levels, suggesting its potential role as a genetic biomarker of cardiovascular risk. | |
| dc.identifier.citation | Urbano-Cano, A. L., Álvarez-Rosero, R. E., & Liscano, Y. (2025). Association of CETP, APOA5, IL6, and PON1 Gene Variants with Dyslipidemia and Cardiovascular Risk in a Population from Cauca Department, Colombia. Genes, 16(5), 1–24. https://doi.org/10.3390/genes16050545 | |
| dc.identifier.issn | 20734425 | |
| dc.identifier.uri | https://repositorio.usc.edu.co/handle/20.500.12421/7524 | |
| dc.language.iso | en | |
| dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | |
| dc.subject | APOA5 | |
| dc.subject | cardiovascular risk | |
| dc.subject | CETP | |
| dc.subject | genetic polymorphisms | |
| dc.subject | IL6 | |
| dc.subject | PON1 | |
| dc.title | Association of CETP, APOA5, IL6, and PON1 Gene Variants with Dyslipidemia and Cardiovascular Risk in a Population from Cauca Department, Colombia | |
| dc.type | Article |