Autoimmune Hemolytic Anemia Caused by Cold Agglutinin Antibodies in Systemic Lupus erythematosus—a Rare Association: Case Report
| dc.contributor.author | Osorio Toro, Luis Miguel | |
| dc.contributor.author | Quintana Ospina, Jhon Herney | |
| dc.contributor.author | Melo Burbano, Luis Álvaro | |
| dc.contributor.author | Ruiz Jiménez, Paola Andrea | |
| dc.contributor.author | Daza Arana, Jorge Enrique | |
| dc.contributor.author | Rivas Tafurt, Giovanna Patricia | |
| dc.contributor.author | Izquierdo Loaiza, Jorge Hernán | |
| dc.date.accessioned | 2025-07-08T22:40:45Z | |
| dc.date.available | 2025-07-08T22:40:45Z | |
| dc.date.issued | 2023-09-04 | |
| dc.description | Las anemias hemolíticas autoinmunes (AIHA) son trastornos raros y heterogéneos caracterizados por la destrucción de glóbulos rojos por anticuerpos calientes o fríos. La anemia hemolítica asociada a anticuerpos calientes es la más frecuente, mientras que los anticuerpos fríos son raros e infrecuentes en los casos publicados en la literatura científica. Presentamos el caso de una paciente joven con lupus eritematoso sistémico (LES) y anemia hemolítica autoinmune causada por anticuerpos fríos. Inicialmente se consideró etiología infecciosa y neoplasia hematológica, que fueron descartadas. Requirió tratamiento en la unidad de cuidados intensivos debido a la grave afectación hematológica y respondió bien al tratamiento inmunomodulador. Este caso ilustra la importancia de una fuerte sospecha clínica de AIHA por aglutininas frías asociada a LES ante síntomas clínicos similares para lograr un diagnóstico oportuno y proporcionar una terapia óptima. | |
| dc.description.abstract | Autoimmune hemolytic anemias (AIHAs) are rare and heterogeneous disorders characterized by the destruction of redblood cells by warm or cold antibodies. Hemolytic anemia associated with warm antibodies is the most common, whereas coldantibodies are rare and infrequent in cases published in the scientific literature. Herein, we present the case of a young patient withsystemic lupus erythematosus (SLE) and autoimmune hemolytic anemia caused by cold antibodies. Initially, infectious etiology andhematological malignancy were considered, which were ruled out. She required management in the intensive care unit due to severehematological involvement and responded well to immunomodulatory therapy. This case illustrates the importance of a strong clinicalsuspicion of AIHA due to cold agglutinins associated with SLE when faced with similar clinical symptoms in order to achieve a timelydiagnosis and provide optimal therapy. | |
| dc.identifier.citation | Osorio-Toro, L. M., Quintana-Ospina, J. H., Melo-Burbano, L. Á., Ruiz-Jiménez, P. A., Daza-Arana, J. E., Rivas-Tafurt, G. P., & Izquierdo-Loaiza, J. H. (2023). Autoimmune Hemolytic Anemia Caused by Cold Agglutinin Antibodies in Systemic Lupus erythematosus—a Rare Association: Case Report. Journal of Blood Medicine, 14, 507–511. https://doi.org/10.2147/JBM.S420937 | |
| dc.identifier.issn | 11792736 | |
| dc.identifier.uri | https://repositorio.usc.edu.co/handle/20.500.12421/7302 | |
| dc.language.iso | en_US | |
| dc.publisher | Dove Medical Press Ltd | |
| dc.subject | antibodies | |
| dc.subject | autoimmune diseases | |
| dc.subject | autoimmune hemolytic anemia | |
| dc.subject | systemic lupus erythematosus | |
| dc.title | Autoimmune Hemolytic Anemia Caused by Cold Agglutinin Antibodies in Systemic Lupus erythematosus—a Rare Association: Case Report | |
| dc.type | Article |
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