Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon

dc.contributor.author	Vera Lizcano, Omaira
dc.contributor.author	Resende, Sarah Stela
dc.contributor.author	Chehuan, Yonne F.
dc.contributor.author	Guimarães Lacerda, Marcus Vinicius
dc.contributor.author	A. Brito, Cristiana F.
dc.contributor.author	Zalis, Mariano G.
dc.date.accessioned	2019-08-08T06:00:10Z
dc.date.available	2019-08-08T06:00:10Z
dc.date.issued	2014
dc.description.abstract	The molecular basis of Plasmodium vivax chloroquine (CQ) resistance is still unknown. Elucidating the molecular background of parasites that are sensitive or resistant to CQ will help to identify and monitor the spread of resistance. By genotyping a panel of molecular markers, we demonstrate a similar genetic variability between in vitro CQ-resistant and sensitive phenotypes of P. vivax parasites. However, our studies identified two loci (MS8 and MSP1-B10) that could be used to discriminate between both CQ-susceptible phenotypes among P. vivax isolates in vitro. These preliminary data suggest that microsatellites may be used to identify and to monitor the spread of P. vivax-resistance around the world.	en_US
dc.identifier.issn	0074-0276
dc.identifier.uri	https://repositorio.usc.edu.co:8443/xmlui/handle/123456789/520
dc.language.iso	en	en_US
dc.publisher	Memorias do Instituto Oswaldo Cruz	en_US
dc.subject	Plasmodium vivax	en_US
dc.subject	chloroquine	en_US
dc.subject	resistance	en_US
dc.title	Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon	en_US
dc.type	Article	en_US

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