Medicina - Palmira

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Fagoterapia: una nueva alternativa terapéutica en la resistencia a los antibióticos - revisión sistemática
(Universidad Santiago de Cali, 2023) Osorio Hernández, Sofía; Perea Gordillo, Laura Sofía; Arana Domínguez, Johan Daniel (Director); Molano Agudelo, Pedro (Codirector)
Discovered in 1917, bacteriophages are viruses that parasitize and lyse bacteria, releasing new phages and forming the basis of phage therapy, a non-antibiotic medical technique being investigated as an alternative to combat growing global antimicrobial resistance. Given this global challenge, a systematic review (following the PRISMA 2020 guidelines) was conducted in databases like Scopus and PubMed, including 28 articles published between 2017 and 2023. The collected evidence showed that Europe leads the research on phage therapy aimed at antibiotic resistance, highlighting its advantages such as high specificity, low cost, and low rate of side effects, along with its ability to control infections. However, phage therapy faces significant limitations hindering its widespread clinical use, including the lack of extensive studies to understand phages' genome and properties, the absence of a standard regulatory framework, and the complexity of selecting the correct bacteriophage for a specific bacterial infection.