Química

Permanent URI for this collection

Now showing 1 - 1 of 1

Análisis voltamétrico de losartán potásico en electrodo de carbono vítreo dopado con 3,4- polietilendioxitiofeno (pedot)
(Universidad Santiago de Cali, 2022) Giraldo Balcázar, José Daniel; Gutierrez Moreno, Nini Johanna (Directora)
Electrochemical results are presented for the sensitive, repeatable and high percentage recovery determination of Losartan potassium (LOS) by voltammetric techniques on bare glassy carbon electrode doped with 3,4- polyethylenedioxythiophene (PEDOT). Effects associated with the type of electrolyte establish that LOS exhibits a 29% increase of the peak current in Buffer Britton Robinson (BBR) pH 8.5 with respect to Buffer phosphate (BF) at pH 6.0; establishing that the molar electrosorption capacity of P affects the electrochemical signal. Studies associated with the sweep speed do not present substantial differences in the diffusion coefficient in both electrolytes. Low-range calibration curves for the bare electrode are between 10-100M (R2 = 0.9958), and with PEDOT between 0.1- 1.0M (R2 = 0.9911). Both electrodes show coefficient of variation percentages of less than 4% in repeatability and reproducibility tests. The deposition of PEDOT on the glassy carbon electrode improves the detection limit from 10.0M to 0.1M. The analytical ranges are applicable to commercial pharmacological samples with recovery percentages higher than 97.0% similar to high performance chromatographic (HPLC) techniques.