Browsing by Author "Usma Montiel, Alejandra"
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Item Evaluación de la actividad antibacteriana de ampicilina encapsulada dentro de nanoliposomas funcionalizados frente a Staphylococcus aureus(Universidad Santiago de Cali, 2022) Llanten Llanten, Mónica Gineth; Usma Montiel, Alejandra; Oñate Garzón, José Fernando; Salamanca Mejía, ConstainAntibiotic resistance is a major public health problem, as antibiotics are the main tool for treating infectious diseases. This project aims to prepare a carrier for an antibiotic such as ampicillin that has been used in medicine for its broad antimicrobial spectrum against gram-positive bacteria. This carrier will be able to improve its permeability and antimicrobial activity against sensitive and resistant S. aureus. Functionalized liposomes with low molecular weight chitosan were used, which were prepared by the ethanol injection technique and physicochemical characteristics were measured. In addition, antimicrobial activity tests were performed. The results of this work were stable but not acceptable in terms of the elaboration and stability of the nanosystems, but the antibacterial test was not as expected, since the nanosystems did not allow ampicillin to be effective against S. aureus strains by His composition