Química
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Browsing Química by Author "Amelines Sarria, Oscar Felipe (Director)"
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Item Estudio de métodos de extracción y análisis de los cannabinoides CBD, CBN, ∆9-THC en la planta de Cannabis sativa L(Universidad Santiago de Cali, 2022) Mejía Ríos, Luis Carlos; Amelines Sarria, Oscar Felipe (Director)This study reviews the extraction methodologies applied to the plant of Cannabis sativa L. It describes the conditions of these methodologies and which of them presents better yields for the cannabinoids, cannabidiol (CBD), tetrahydrocannabinol (∆9-THC) and cannabinol (CBN), the methods of analysis of these and the medicinal uses are also examined. The systematic review was performed in accordance with PRISMA guidelines. The databases used were ScienceDirect, Springer, Scopus and Google Scholar. It has been reported that the cannabinoids CBD, ∆9-THC and CBN have pharmacological properties which can cover needs in certain pathologies such as cancer, glaucoma, epilepsy, Parkinson's and COVID-19. The supercritical carbon dioxide extraction methodology was found to be the most widely used and the most environmentally friendly. The HPLC-MS and GC-MS methods of analysis proved to be suitable for analyzing the cannabinoids studied in this systematic review.Item Implementación de una técnica analítica por espectroscopia infrarrojo cercano (NIR) para la determinación y cuantificación de óxido de zinc en crema tópica al 40%(Universidad Santiago de Cali, 2022) Montoya Candelo, Sandra Viviana; López Parra, Lizbeth Lorena (Directora); Amelines Sarria, Oscar Felipe (Director)In the present work, the validation of the NIR spectroscopy methodology for the quantification of zinc oxide in 40% topical cream was carried out, evaluating different analytical parameters by means of a calibration curve, resulting in adequate analytical precision ( intermediate precision with CV0.998 and recoveries between 97% - 103% for accuracy, robustness was also evaluated with 3 different factors that could influence the determination of zinc oxide, to then carry out a comparative study between the methodology by volumetry and the NIR methodology.Finally, the application of green chemistry was taken into account, evaluating the twelve principles established by Anastas and Warner; a score of 10 on the Likert scale for the NIR spectroscopy methodology in the quantification of ZnO in 40% topical cream, also achieving a decrease in co This and analysis time, reagent savings, and reduction of polluting waste that could generate a greater environmental impact, with the use of this technique in the company.