Browsing by Author "Villamizar Delgado, Stephanny"
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Item Síntesis y caracterización de metalofármacos obtenidos a partir de metformina con CU2+, NI2+, CO2+, ZN2+ Y BI3+, con potencial uso para el tratamiento del sobrepeso(Universidad Santiago de Cali, 2019) Villamizar Delgado, Stephanny; D´vries Arturo, Richard; Piñeros, OctavioA series of coordination compounds of Cu(II), Ni(II), Co(II), Zn(II) and Bi(III) with a type of biguanide (known commercially as Metformin Hydrochloride) have been synthesized and characterized by means of spectroscopic techniques (FT-IR, UV / VIS), X-ray diffraction techniques and thermal analysis. From single-crystal X-ray diffraction data, it was possible to completely characterize the compound of formula [Co(C4H11N5)3](Cl)2·(H2O)2. The compound obtained crystallizes in the monoclinic space group C2/c, with one molecule per asymmetric unit and is reported for the first time. The compounds obtained will be evaluated by means of biological tests in order to clarify their actions by physiopathological mechanisms that intervene in the control of appetite, the increase in body weight and other associated metabolic factors.