Browsing by Author "Velasco Tovar, Valeria"
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Item Identificación de variantes genéticas en genes asociados a la respuesta inmune Th1 y th2 en un grupo de personas de la ciudad de Cali(Universidad Santiago de Cali, 2025) Velásquez Osorio, Daniel Alejandro; Velasco Tovar, Valeria; Matta Miramar, Andrés Jenuer (Director); Zambrano, Diana Carolina (Directora)Introduction: The study of diseases and their relationship with genetics is mostly focused on autoimmune pathologies and cancer, leaving aside the possible interactions that exist between genetic mutations and susceptibility to infections, this idea derives from how the presence of polymorphisms can affect the production of different proteins, within which cytokines can be found, which are responsible for mediating interactions that regulate the immune system, if it is possible to find a relationship between polymorphisms and how they affect the correct functioning of the immune response, an advance in epidemiological control will be achieved by making use of the genetic analysis of a population. Objective: To identify polymorphisms in genes that are expressed in cytokines that make up the Th1 and Th2 immune responses in the genomes of healthy people from the city of Cali. Methodology: In order to fulfill the stated objective this study will use information derived from the project “Intestinal microbiota associated with Helicobacter pylori and its relationship with variants in genes associated with the development of gastric cancer in healthy people from Valle del Cauca” in this case we have available the position and which are the polymorphisms found in the 23 pairs of chromosomes of 23 different healthy subjects, from these databases a selection will be made based on the location within the chromosomes of the most recurrent cytokines in the studies of the functioning of the Th1 and Th2 immune response; when selecting the proteins and their locus, the genes of the 23 individuals will be organized having as purpose to know the frequency of appearance, which is its presence in allelic and which polymorphism is in turn the effect of the presence of the polymorphisms on the cytokines will be evaluated. Results:We found 1342 mutations associated with key cytokines in 23 patients, determining that there are a total of 264 polymorphisms present in the participants, of these we obtained 17 polymorphisms and 4 of them with a protein change and only 1 with both a protein change and a high frequency to be representative. Conclusions: We were able to identify a polymorphism capable of causing protein changes of 264 polymorphisms studied, the polymorphism distinguished with a rs20541 can be translated into a change in the cytokine which refers to interlucin 13, generating an alteration in the reference nucleotide and a structural change of potential energy in interlucin 13.