Browsing by Author "Vargas Arboleda, Carmen Elena"
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Item Propuesta de mejora para el manejo de la cadena de frio de medicamentos en Centro Hospitalario en la ciudad de Cali(Universidad Santiago de Cali, 2017) Vargas Arboleda, Carmen Elena; Arboleda Zuñiga, JairoIt is universally admitted that the concept of quality of a medicine includes two basic characteristics: efficacy and safety. While efficacy is defined as the ability of a medication to obtain the therapeutic action sought in a timely manner, it is understood that a medication is safe as long as the risks it has for the patient are acceptable in terms of a risk-benefit analysis. . Among the required quality requirements for a drug is its stability, that is, the ability of a particular formulation in a specific container / closure system, to remain within its physical, chemical, microbiological, therapeutic and toxicological specifications throughout of the entire period in which it is in the market. There are many factors that affect the stability of the drug from its manufacture until the moment of its use, so that deficiencies in the preservation systems (cold chain break) or in the type of packaging can wreak havoc on the stability of a medicine. It should be noted that products formed as a result of drug degradation, although, in general, lack pharmacological activity, can sometimes be potentially toxic or lead to alterations in organoleptic characteristics. To avoid or delay this type of reaction, a series of measures can be taken, among which we can highlight the temperature control, since an increase in temperature, in general terms, is accompanied by an increase in the degradation rate (G r J rt Ru S u T - 2004).