Browsing by Author "Varela Miranda, Rubén Eduardo"
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Item AKT-like as part of the cell survival signaling pathways of Trypanosoma cruzi and Trypanosoma brucei(Universidad de Antioquia, 2019-07-15) Díez Mejía, Andrés Felipe; Varela Miranda, Rubén Eduardo; Pulido Muñoz, Sergio Andrés; Echeverry Gaitán, María Clara; Marín Villa, MarcelLas quinasas han sido descritas como las proteínas encargadas de la emisión y transducción de señales en la célula, generando respuestas que van desde la regulación de la homeostasis celular, hasta el control de la respuesta a estímulos. Dada la importancia de estas proteínas, reportadas como esenciales, actualmente existen medicamentos basados en la inhibición de quinasas, los cuales se emplean en el tratamiento de patologías como el cáncer y cuyas investigaciones se han extrapolado a la búsqueda de alternativas quimioterapéuticas para combatir enfermedades como la leishmaniasis, la tripanosomiasis americana y la africana, encontrando a las proteínas de la vía de las PI3Ks como dianas prometedoras.Item Síndrome post covid-19, implicaciones funcionales y factores relacionados(Universidad Santiago de Cali, 2024-08-23) Daza Arana, Jorge Enrique; Varela Miranda, Rubén EduardoCOVID-19 is a viral infection that has generated a high burden of morbidity and mortality during the pandemic worldwide, becoming a disabling disease in the population that persists with symptoms after 12 weeks of SARS-CoV infection. 2 and that no alternative diagnosis is attributed. The functional implications of Post COVID-19 Syndrome include the domains of functional impairment, fatigue, quality of life, mental and/or cognitive function problems, and low exercise capacity. Considering that there are only three studies in the country in relation to this syndrome, it was necessary to investigate the municipality of Palmira because it is one of the territories with the highest number of cases in the department of Valle del Cauca and one of those that has greater lethality. A descriptive observational epidemiological study with an analytical component was carried out that allowed us to describe and know the frequency of persistent symptoms, the functional implications and the burden of the affected systems, in relation to the sociodemographic and clinical characteristics. It was found that the population was mainly female, middle and low socioeconomic stratum, had a single event of COVID-19, more than 5 symptoms in the acute stage and received outpatient management. The majority presented a complete vaccination schedule against COVID-19, but only 26.9% had vaccination prior to infection. It was evident that cognitive symptoms represented 88.5% of the persistent symptoms, followed by general (84.6%), musculoskeletal (82.7%) and neurological symptoms (75.8%). In functional status, 70% present minimal to severe limitations. Chronic fatigue had a prevalence of 36.5% (38/104). Regarding quality of life, it was observed that half (50.0%) of the population reports a mild to moderate level of pain or discomfort and around a third (34.6%) a level of anxiety and depression. Cognitive mental function was found with 55.8% at a reduced level. The most affected areas were memory with 88.5%, followed by the visuospatial/executive area with 71.2% and attention 61.5%. It was evidenced that a single episode of acute COVID-19, without critical illness, can develop Post-COVID-19 Syndrome and subsequent vaccination does not seem to be a protective factor. After evaluating the results obtained in this population, the implementation of prevention and management strategies is recommended that facilitate comprehensive rehabilitation in a timely manner with the aim of reducing functional implications.