Browsing by Author "Valencia Torres, Miguel"
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Item Grasa abdominal relacionada con la enfermedad de Alzheimer, revisión sistemática(Universidad Santiago de Cali, 2024) Gutiérrez Morales, Luis Fernando; Orozco Sotelo, Carlos Arturo; Valencia Torres, Miguel; Nieto, Luis Hernesto (Director)Greater amounts of visceral abdominal fat in middle age are linked to the development of Alzheimer's disease; Visceral fat is the fat that surrounds the internal organs deep in the abdomen. Several studies show that this hidden abdominal fat is linked to changes in the brain up to 15 years before the first memory loss symptoms of Alzheimer's disease occur. Recent publications have described mild cognitive impairment and dementia with a higher prevalence in Colombia than in the rest of Latin America. According to the Alzheimer's Association, there are more than 46.8 million people in the world living with the disease. of Alzheimer's. By 2050, this number is expected to increase to almost 131.8 million where one in five women and one in 10 men will develop Alzheimer's disease during their lifetime, becoming a major public health problem due to the increase in life expectancy. The articles found and analyzed to identify the risks of Alzheimer's several years in advance, showed that the association between brain MRI volumes, as well as amyloid and tau uptake in positron emission tomography (PET) scans, with the index Body mass (BMI), obesity, insulin resistance and abdominal adipose tissue in a cognitively normal middle-aged population interfere with communication between brain cells. Although there have been other studies linking BMI to brain atrophy or even an increased risk of dementia, no previous study has linked a specific type of fat to the actual Alzheimer's disease protein in cognitively normal people. Similar studies have not investigated the differential role of visceral and subcutaneous fat, especially in terms of Alzheimer's amyloid pathology, already in middle age.