Browsing by Author "Silva Correa, Herlen Dallana"
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Item Review: química forense. Métodos de extracción y detección de sustancias psicoactivas en cabello y uñas"(Universidad Santiago de Cali, 2025) Silva Correa, Herlen Dallana; Rios Acevedo, Jhon Jairo (Director)The detection of psychoactive substances in keratin matrices such as hair and nails has been a challenge for forensic toxicology due to the need for accurate, sensitive and reproducible methods to identify chronic use or prolonged exposure to drugs. This review aimed to evaluate recent studies on analytical methods employed between 2020 and 2025, with emphasis on improving recovery rate, extraction time and limit of detection (LOD). A systematic review of scientific studies describing extraction and detection techniques applied to keratin matrices was performed. This included comparative analyses of methods such as solid-phase extraction, solid-phase microextraction, ultrasound-assisted extraction and new on-line strategies. Detection technologies such as LCMS/MS, HRMS, GC-MS and biosensors were also evaluated. The results showed a clear trend towards more efficient, sustainable methods with high capacity for multianalyte analysis, as chromatographic techniques coupled to mass spectrometry offered high sensitivity and specificity, while emerging technologies stood out for their speed and portability, although with limitations in sensitivity.