Browsing by Author "Segura Castillo, Linda Nerieth (Directora)"
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Item Análisis de los avances más recientes en nanotecnología y su aplicación en ingeniería de tejidos: Una revisión bibliográfica(Universidad Santiago de Cali, 2024) Contreras Tovar, Allisson Andrea; Chamorro Valencia, Luz Daniela; Gordon Irua, Edwin Adrián; Segura Castillo, Linda Nerieth (Directora)Introduction: Nanotechnology is the study and manipulation of matter at the nanometer scale, i.e., in the range of 1 to 100 nanometers. This discipline enables the creation of materials and devices with unique properties not found in their macroscopic form. Nanotechnology is used in a variety of areas, including drug delivery, bioimaging, and tissue engineering (TI). Objective: To analyze the current state of research and development of nanotechnology in the field of TI. Materials and Methods: A review of the literature published in databases such as ScienceDirect and Springer between the years 2020-2024 was carried out using search equations. A total of 254 records were found, of which 55 were included in this review after applying the previously established selection criteria. Results: Nanomaterials, such as carbon nanotubes and nanoparticles, improve the mechanical properties and biocompatibility of biomaterials, facilitating tissue regeneration and integration with the biological environment. However, it also faces challenges, such as high production costs and the need to ensure safety and efficacy in clinical applications. Conclusions: Despite current challenges, continued research and interdisciplinary collaboration are essential to overcome barriers and maximize the effectiveness of nanotechnology-based treatments. Future developments in this field are expected to contribute to improved clinical outcomes and expand the applications of nanotechnology in medicine.Item Análisis de los factores de riesgo determinantes en el fracaso de los trasplantes de medula ósea en pacientes pediátricos. Revisión Bibliográfica(Universidad Santiago de Cali, 2024) Miranda Pérez, Katalina; Castañeda Caicedo, Karen Liseth; Segura Castillo, Linda Nerieth (Directora)Introduction: Bone marrow transplantation in pediatric patients is a complex procedure that involves significant risks, such as severe infections, bleeding and anemia, which may even endanger the patient's life. Given the importance of this procedure for the quality of life of children, it is crucial to understand the risk factors that influence its success or failure. Objective: To analyze the determinant risk factors for bone marrow transplant failure in pediatric patients. Materials and methods: This study focused on reviewing the available scientific literature to identify and analyze these determinant factors. The methodology employed consisted of a qualitative investigation based on the review of recently published relevant studies and clinical cases. Exhaustive searches were conducted in scientific databases such as PubMed, Science Direct, Scopus and Google Scholar. Results: There are several challenges regarding bone marrow transplantation in pediatric patients, with genetic compatibility between donor and recipient being crucial, in addition, post-surgical care, choice of nutrition, prevention of graft-versus-host disease, careful donor selection, use of tailored conditioning regimens and elimination of contaminating malignant cells are crucial for successful transplantation. Conclusion: It is emphasized that the selection of bone marrow transplantation technique in pediatric patients depends on several factors, including genetic compatibility, the patient's health status and the presence of underlying diseases. In addition, therapeutic advances such as reduced-intensity conditioning regimens offer new hope, but a multidisciplinary and personalized approach is required to ensure optimal outcomes and improve quality of life.Item Comparación del uso de la membrana amniótica frente al autoinjerto de conjuntiva en cirugía ocular: Revisión bibliográfica(Universidad Santiago de Cali, 2024) Cuellar Urrutia, Laura Camila; Palomino Suarez, Nicolle Dahyan; Valencia Becerra, Evelyn; Segura Castillo, Linda Nerieth (Directora)Introduction: Pterygium, also known as "surfer's eye", is a benign lesion characterized by an abnormal fibrovascular growth taking a triangular or wing shape, composed of an epithelium and loose subepithelial connective tissue, limbal and conjunctival tissue largely vascularized. Objective: To compare the use of amniotic membrane versus conjunctival autograft in pterygium resection surgery, based on results of clinical cases. Materials and methods: A search was performed based on studies taken from the following databases accompanied by the respective number of articles used in the tracking matrix, starting with Pubmed (28), Web of Science (17), Google Scholar (11), ScienceDirect (8), Scopus (8), Dialnet (4), Nature (2), Taylor & Francis Group (1) and Springer Link (1). Results: Studies have shown that the combination of MA with antifibrotic agents such as mitomycin C can reduce the recurrence rate to 10-15%, approaching the results obtained with conjunctival autograft, but the use of MA alone can lead to higher recurrence rates; this has generated an interest in optimizing fixation techniques and adjuvant treatments to improve long-term clinical results. Conclusion: Both techniques have been shown to be effective in reducing pterygium recurrence; however, conjunctival autograft is distinguished by its ability to offer a lower long-term recurrence rate; this finding reinforces the relevance of selecting the most appropriate surgical technique based on the characteristics of the pterygium and the particularities of each patient. Keywords: Pterygium, amniotic membrane, conjunctival autograft, recurrence, fixation methods, grafts, ocular surgery.Item Conocimiento y cumplimiento de procesos de desinfección y esterilización en una clínica odontológica de una universidad privada, Cali 2024(Universidad Santiago de Cali, 2024) Peña Triana, Karen Sofia; Salcedo Guarín, Stephani; Segura Castillo, Linda Nerieth (Directora)Item Conocimientos y prácticas en procesos de esterilización de los auxiliares de enfermería, en las centrales de esterilización de las sedes de Cali y Jamundí de la IPS VALLESALUD, periodo 2020A(Universidad Santiago de Cali, 2019) Gasca Cruz, Daniela; Ruiz Pizarro, Santiago Adolfo; González Ledesma, Diana Marcela; Segura Castillo, Linda Nerieth (Directora)Item Efectividad del óxido de etileno como agente esterilizante versus su acción tóxica en el personal sanitario(Universidad Santiago de Cali, 2020) Echeverri Burbano, Catalina; Molina Girón, Laura Isabel; Segura Castillo, Linda Nerieth (Directora)The collateral effects on the health of health personnel caused by the management of ethylene oxide as a sterilizing agent involve complications with the various systems of the human body: neurological, cardiovascular, dermatological and endocrine, respiratory, ocular systems, among others. These effects can be exacerbated by bad practice regarding the use of the specific biosecurity elements of this gas or insufficient infrastructure of the sterilization plant that uses this method. However, the healthcare institutions that have in their installed capacity a sterilization plant equipped with the equipment, pipes and all the ornamentation necessary to handle this gas, despite the contraindications to the health of the personnel it manages. In this area, they continue to use this gas as a sterilizing agent. This is why, as researchers, the question arises about the true complication of ethylene oxide as a sterilant compared to the possible complications that may be contrary to personnel, or if its sterilizing action can be replaced by another method that carries less risks for the worker.Item Evaluación del conocimiento ambiental en estudiantes de quinto a octavo semestre de Instrumentación Quirúrgica de la Universidad Santiago de Cali, 2019(Universidad Santiago de Cali, 2020) Erazo Delgado, Karen Liliana; Ortiz Ángel, Laura María; Trujillo Ayala, Nathalia; Segura Castillo, Linda Nerieth (Directora)Item Evolución de los tratamientos alternativos para el rejuvenecimiento facial: Una revisión bibliográfica(Universidad Santiago de Cali, 2023) Palencia Ramírez, Loren Ibeth; Palma Parra, Shirley; Carvajal Cuero, Daniela; Segura Castillo, Linda Nerieth (Directora)The general objective of this literature review is to analyze the evolution of alternative treatments for facial rejuvenation. In order to collect the necessary and reliable information, a review was carried out in the databases Google Scholar, Springer, Taylor and Francis group, Science Direct, PubMed, Nature, Dialnet, and Scopus, taking as a date range the years between 2018 and 2023, including scientific articles, theses, and review articles. The results can be very useful for the facial cosmetic surgery sector in terms of the combination of surgical processes and technological advances to ensure optimal results for patients, while motivating the search for improvement of techniques for the benefit of reducing the rate of complications as much as possible. Rhytidoplasty is the option that best suits the needs of those interested in correcting certain facial anomalies typical of aging; in this research is reflected in the professionalism with which each procedure is performed for the benefit of giving the patient a youthful appearance without losing the naturalness of the face.Item Frio silencioso: Consecuencias y manejo de la hipotermia durante la cirugía. Revisión bibliográfica(Universidad Santiago de Cali, 2024) Gómez Chacón, Lilibeth; Ruiz Lozano, Valentina; Vallejo Castañeda, Elías; Segura Castillo, Linda Nerieth (Directora)Introduction: Intraoperative hypothermia is a complication that can occur during surgical procedures, especially those that are of long duration or involve patient exposure to cold temperatures. Reducing body temperature to levels below normal can have serious consequences for the patient, as well as impact the surgical process. Objective: To know the causes and risk factors of hypothermia during surgery. Materials and Methods: A systematic review was carried out using databases such as the Virtual Health Library, PubMed, Science Direct, the Spanish Bibliographic Index in Health Sciences (IBECS), Springer Link, Web of Science, Google Scholar, Directory of Open Access Journals, among others. Results: It was possible to identify that perioperative hypothermia is a common and significant complication that affects a large number of patients undergoing surgery. It is estimated that between 70% and 90% of patients develop hypothermia during surgical procedures, which can have serious consequences for the patient's health. Conclusions: Hypothermia is associated with an increased incidence of surgical site infections. This is due to impaired immune function, affecting the ability of neutrophils and macrophages to fight infections, as well as decreased blood flow that limits oxygen delivery to affected tissues.Item Índice de repitencia de los estudiantes del programa de Instrumentación Quirúrgica de la Universidad Santiago de Cali de 2014A 2018A(Universidad Santiago de Cali, 2020) Arbeláez Santander, Natalia; Rojas Guerrero, Liseth Manuela; Peñaranda Alarcón, María Alejandra; Segura Castillo, Linda Nerieth (Directora)Item Manejo de residuos de riesgo biológico y químico, generados en quirófanos de centros sanitarios latinoamericanos desde el año 2015 hasta el año 2020(Universidad Santiago de Cali, 2020) Quiceno Gómez, Nicholas; Valdés Bermúdez, Marcos Brayan; Segura Castillo, Linda Nerieth (Directora)Surgical rooms are the most important area and highlight of the surgical process, therefore, health care institutions optimally condition those spaces as required by Colombian law and guarantee to provide the best quality services and patient care With medical-surgical personnel trained to carry out the various procedures, in turn, essential supplies are used in the environment, since it is there that hazardous hospital waste is generated, such as those of chemical and biological risk.Item Principales usos de la terapia génica en el tratamiento de diversas enfermedades: Una revisión bibliográfica(Universidad Santiago de Cali, 2024) Obando Castiblanco, Natalia; Tovar Pazmiño, Natalia; Riascos Sinisterra, Anette Dayana; Segura Castillo, Linda Nerieth (Directora)Introduction: Gene therapy (GT) is a medical technique that involves the introduction, modification, or replacement of genetic material into cells of the body to treat disease. This innovative approach is based on the idea of correcting or replacing defective genes responsible for inherited or acquired diseases. Aim: To know about the main uses of gene therapy in the treatment of various diseases. Materials and methods: A review of the literature published between 2019- 2024 was conducted, using the ScienceDirect and Springer databases, and the Google Scholar repository. Some terms used for the search were “gene therapy”, “epilepsy”, “advances in epilepsy treatment”, among others. A total of 143 articles were obtained, of which 41 met the inclusion criteria and were used in this review. Results: GT has demonstrated good levels of success and promising results in the treatment of conditions such as hemophilia and some neurological disorders, among others; therefore, various forms of GT have been developed, such as the use of CRISPR or adeno-associated virus vectors, which aim to achieve effective delivery of GT, however, there are still challenges to be resolved regarding this form of therapy, especially ethical and social, as well as economic. Conclusions: GT has emerged as a revolutionary tool in the treatment of a wide range of genetic diseases. With a focus on efficacy, safety and personalization of treatments, GT continues to open new perspectives for the treatment of various diseases.Item Situación actual acerca del trasplante de microbiota fecal en el tratamiento de la enfermedad de Crohn: Una revisión bibliográfica(Universidad Santiago de Cali, 2024) Patiño Ramírez, Stephany; González Herrera, Isabela; Segura Castillo, Linda Nerieth (Directora)Introduction: Crohn’s disease (CD), a form of inflammatory bowel disease (IBD), presents as a complex and multifaceted medical challenge affecting the gastrointestinal tract. It is characterized by chronic inflammation of the gastrointestinal tract, affecting anywhere from the mouth to the anus. Aim: To know about the most recent advances in FMT for treating CD. Materials and methods: A review of the specialized literature was carried out, using search equations in databases such as PubMed, ScienceDirect and Springer, and in the Google Scholar repository. Eighty-five articles were obtained, 47 of which were used for the review. Results: FMT has shown promising results in treating CD, with response rates in some cases, between 58 and 76%; however, there are still some aspects to resolve regarding treatment such as the recurrence and aggravation of symptoms in patients even after transplantation, or the occurrence of adverse events, among others. Conclusions: Despite encouraging results, further research is needed to obtain conclusive results regarding the efficacy of the treatment, especially concerning patient safety and the permanence of the results in the long term.Item Terapias emergentes para la enfermedad injerto contra huésped (Eich): un nuevo horizonte en el tratamiento. Una revisión bibliográfica(Universidad Santiago de Cali, 2024) Ossa Gómez, Yurany; Ortega Rozo, Luisa María; Galvis Morán, Valentina; Segura Castillo, Linda Nerieth (Directora)Introduction: Graft-versus-host disease (GVHD) is a serious and complex complication that usually arises after allogeneic haematopoietic stem cell transplantation (HSC), however, such a complication, can also occur after bone marrow transplantation or after organ transplantation. Aim: The aim of this study was to evaluate the efficacy and safety of emerging therapies for GVHD. Materials and methods: A review of the literature published between 2019-2024 was performed using search equations in the ScienceDirect and Springer databases. A total of 132 papers were obtained, of which 72 were selected for this review. Results: Treatments such as Ruxolitinib and Ibrutinib have been used, as well as the use of stem cells and extracorporeal photopheresis. The best rates of effectiveness in the treatment of GVHD have been observed with the use of Ruxolitinib. Some studies have reported overall response rates (ORR) higher than 60%, even reaching 63% in certain cases. In addition, treatment with Ruxolitinib has been shown promising results in improving patients’ symptoms as well as their overall quality of life. However, other therapies have also shown good results in treating the disease, which presents a broad picture of the options available to address this post-transplant complication. In addition, research has focused on the analysis of biomarkers to develop more personalized treatments for patients. Conclusions: These advances reflect the importance of continuing to explore and develop new therapeutic strategies to address this post-transplant complication more effectively and improve clinical outcomes in affected patients.