Browsing by Author "Santa Florez, Nerlin Julieth"
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Item Mejora de la administración del Cannabis Medicinal mediante nanotecnología: Optimización de parámetros Farmacocinéticos y Farmacodinámicos para aumento de la biodisponibilidad - Revisión Sistemática(Universidad Santiago de Cali, 2025-07-05) Santa Florez, Nerlin Julieth; Rojas Barreto, Julián Alonso (Director)Medical cannabis has emerged as a promising therapeutic alternative for treating various diseases, primarily due to the pharmacological potential of its main active compounds: tetrahydrocannabinol (THC) and cannabidiol (CBD). However, its clinical use is limited by poor water solubility, chemical instability, variable absorption, and extensive first-pass hepatic metabolism. These pharmacological barriers hinder effective and standardized dosing, reducing therapeutic efficacy and limiting broader clinical application. To address these challenges, nanotechnology has gained prominence as a transformative tool in the development of novel drug delivery systems for cannabinoids. This systematic review analyzes the latest advances in nanotechnological formulations applied to medical cannabis, focusing on their effects on solubility, stability, pharmacokinetics, and bioavailability. Key systems explored include nanoemulsions, lipid-based nanoparticles, and controlled release platforms, all of which have demonstrated improved cannabinoid absorption, distribution, and therapeutic action. The review also examines comparative studies between conventional and nanotechnology-enhanced formulations, highlighting superior performance in terms of bioavailability and clinical effectiveness. Overall, the evidence suggests that nanotechnology offers a promising strategy to overcome the inherent pharmacological limitations of cannabinoids, enhancing both patient outcomes and treatment reliability. This approach not only improves therapeutic efficacy but also opens the door to safer, more precise, and patient- centered medical cannabis therapies in the future.