Browsing by Author "Salazar Romero, Catalina"
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Item Uso del CBD para la Disminución de la Hiperfagia por Ansiedad en el Tratamiento de la Obesidad Humana - Revisión Sistemática(Universidad Santiago de Cali, 2025) Salazar Romero, Catalina; Rojas Barreto, Julian Alonso (Director)This systematic review examines the potential of cannabidiol (CBD) to decrease anxiety-induced hyperphagia in the treatment of obesity, a condition characterized by excess body fat due to an imbalance between caloric intake and energy expenditure. Using qualitative methodology, the available scientific evidence on the dual mechanisms of action of CBD was critically analyzed: the modulation of the anxious state triggering compulsive eating behaviors and the metabolic regulation of adipose tissue. The findings reveal that CBD has a unique pharmacological profile, acting on multiple receptors (CB1, 5-HT1A, TRPV1) and stimulating genes related to energy metabolism (PPARγ, PGC1α). This therapeutic duality, together with an apparently favorable safety profile, positions it as a promising alternative to conventional treatments with limited efficacy or significant adverse effects. However, important limitations remain: scarcity of controlled clinical studies with rigorous methodologies, questions about long-term hepatic safety, regulatory challenges and discrepancies in the quality of marketed products. These limitations underline the need to intensify scientific research, develop standardized therapeutic protocols and evaluate comparative efficacy with conventional treatments to definitively establish the role of medicinal CBD in the comprehensive approach to obesity.