Browsing by Author "Salazar Guerra, Mayra Alejandra"
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Item Contribución antimicrobiana de colistina encapsulada en liposomas recubiertos con Quitosano de alto peso molecular (QHPM) frente a bacterias Gram negativas(Universidad Santiago de Cali, 2023) Cardona Hoyos, Ana Sofía; Salazar Guerra, Mayra Alejandra; Oñate Garzón, José Fernando; Ciro, YhorsPseudomonas aeruginosa is a Gram negative bacterium, which is not considered part of the human microbiota, so it has the ability to adapt to different environmental conditions due to its intrinsic resistance mechanisms to different antibiotics. This pathogen can colonize hospital environments, such as mechanical ventilators, catheters, among others. P. aeruginosa is of great importance worldwide as it is the main pathogen that causes infections in intensive care unit (ICU) patients. This makes it a public health problem since it has shown resistance to antibiotics such as colistin. The purpose of this study is to develop nanoliposomes functionalized with colistin-containing polymers to address the bacterial resistance of Pseudomonas aeruginosa. The method consists of the encapsulation of colistin within nanoliposomes superficially modified with high molecular weight chitosan (QHPM) to subsequently perform physicochemical characterization of the liposomes, where the particle size and zeta potential will be determined using a Zetasizer nano ZSP; The liposomes were characterized using dynamic light scattering and zeta potential where both parameters were observed to fluctuate in relation to polymer coating. Finally, the antimicrobial activity of colistin transported within the nanosystems was evaluated. Which the registered results were promising against isolated resistant Pseudomonas aeruginosa since it was possible to obtain a decrease in the MIC from 4 µg/mL to 2 µg/mL. However, more research is needed to determine the safety and efficacy of this strategy in humans